Primary Chordoma of the Lung

Strano, Salvatore; Ouafi, Lamia; Baud, M.; Alifano, Marco

doi:10.1016/j.athoracsur.2009.05.043

Cited by 16 publications

(15 citation statements)

References 5 publications

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“…Tumor diameter often ranged between 1.0 and 4.0 cm with mild lobulation. No glitches, satellite lesions or enlarged lymph nodes at the hilus of lung or mediastinum were observed (11). In the present study, patients with enhanced CT scan presented similarly with those in the literature.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary chondroma: A clinicopathological study of 29 cases and a review of the literature

Tian

Wen

Zhou

et al. 2016

Molecular and Clinical Oncology

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The present retrospective study was designed to review the clinicopathological features and outcome of surgical treatment of pulmonary chondroma, and to accumulate data for the clinical diagnosis and therapy. The clinicopathological data from 29 patients, aged between 38- and 78-years-old, with pulmonary chondroma who underwent surgical operation between July 2003 and June 2015 were reviewed. Of these patients, 18 exhibited no clinical symptoms, 7 were characterized by coughing, hemoptysis, shortness of breath and other symptoms and only 3 patients exhibited chest pain as the predominant symptom. The average size of the neoplasms was 3.6 cm. All patients were pathologically diagnosed. Operative time was 126±22 min, the mean intraoperative blood loss was 82±23 ml and the drainage duration was 3.1±1.8 days. A total of 6 postoperative complications were noted. The patients were followed-up for 2–135 months. A total of 23 patients were alive without recurrence, 4 patients succumbed to mortality, 2 patients were lost at follow-up. Pulmonary chondroma is a rare benign tumor of the lung. The clinical symptoms were concealed and often misdiagnosed as a tuberculosis tumor, hamartoma, peripheral lung cancer or a single metastatic tumor. Complete resection was the best treatment providing patients with a good prognosis. After definite diagnosis, it is necessary to exclude Carney's triad.

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Section: Discussionmentioning

confidence: 99%

Pulmonary chondroma: A clinicopathological study of 29 cases and a review of the literature

Tian

Wen

Zhou

et al. 2016

Molecular and Clinical Oncology

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“… 3 , 7 , 8 Besides soft tissue, there are a few reports of chordomas that originate in the lungs, which is currently the only reported visceral organ where extraosseous chordomas occur. 9 , 10 Interestingly, Kikuchi et al 11 recently reported 2 cases of incidental notochordal tumors of the lung that were indicative of BNCTs, as evidenced by brachyury expression. Furthermore, Lee et al 12 reported an additional case of BNCTs in both the lungs.…”

Section: Discussionmentioning

confidence: 99%

Extraosseous Benign Notochordal Cell Tumor Originating in the Lung

et al. 2015

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Benign notochordal cell tumors (BNCTs) are tumors originating in the axial skeleton, where chordomas occur. Although very rare, some cases of extraosseous chordoma, such as in the soft tissue and lungs, have been reported. We report a case of a primary tumor showing the notochordal characteristics of BNCTs within the axial skeleton.An asymptomatic 57-year-old woman presented with an abnormal shadow on her chest radiograph; chest computed tomography revealed a well-defined round nodule. The resected sample tissue contained a jelly-like small nodule. Histologically, it was identified as a BNCT, based on minimal nuclear atypia, extremely low mitotic activity within the tumor cells lying in a sheet-like arrangement, and focal immunopositivity for brachyury.This is the third case report of BNCT originating in the lungs; BNCTs are considered asymptomatic tumors that are identified by using highly developed chest imaging technology; however, our findings also suggest that these notochordal tumors may potentially originate from extraosseous sites that lack ideal precursor cells. Our case suggests that notochordal tumors can arise from organs that are unrelated to known notochordal development.

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“…Chordomas are uncommon bone malignancies and extra-axial chordomas are extremely rare. To our knowledge, only two cases of primary pulmonary chordoma have been reported [ 2 , 3 ]. We believe that the present case is the first report of multiple chordomas of the lung.…”

Section: Discussionmentioning

confidence: 99%

“…A possible mechanism for development of pulmonary chordomas is that they have derived from multipotent cells in the lung parenchyma or a notochordal remnant with aberrant migration from the midline [ 2 ]. As to extra-axial chordomas in species other than human, intestinal chordomas have been reported in zebrafish [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Multiple primary chordomas of the lung

Ohya

Yoshida

Shimojo

et al. 2018

Respiratory Medicine Case Reports

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We here report the case of a 40-year-old man with primary pulmonary chordomas. Although an abnormality had been noted on a chest radiograph at age 26 years, the patient had not undergone further examination at that time because he was asymptomatic. Standard chest radiographs and computed tomography showed slow-growing, multiple bilateral pulmonary nodules. Two tumors were resected thoracoscopically to obtain a diagnosis. Pathologic examination resulted in a diagnosis of chordomas. Subsequent systemic examination revealed no additional lesions, not even in the axial skeleton. The patient is alive without any new lesions 38 months after surgery. These clinical and pathological findings suggest that our patient has multiple primary chordomas of the lung, which is an extremely rare condition.

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Primary Chordoma of the Lung

Cited by 16 publications

References 5 publications

Pulmonary chondroma: A clinicopathological study of 29 cases and a review of the literature

Pulmonary chondroma: A clinicopathological study of 29 cases and a review of the literature

Extraosseous Benign Notochordal Cell Tumor Originating in the Lung

Multiple primary chordomas of the lung

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