Primary cicatricial alopecias: clinicopathology of 112 cases

Tan, Eugene; Martinka, Magdalena; Ball, Nigel J.; Shapiro, Jerry

doi:10.1016/j.jaad.2003.04.001

Cited by 221 publications

(298 citation statements)

References 29 publications

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“…Parietal and fronto-vertical regions were the most frequently involved part of the scalp in the present study which is comparable to what had been reported in the medical literatures [6,9,10].…”

Section: Discussionsupporting

confidence: 92%

“…The mean age of onset inpatients of the present work was 36.7 ± 5 years which is considered younger than that reported by Tan et al [5] where the mean age was 47.4 years and that of Cevasco et al with a mean age was 48.9 years [6].…”

Section: Discussioncontrasting

confidence: 64%

“… The scarring process in LPP is early and pigmented while scarring in DLE is usually late and erythematous  Irregular scarring areas that simulate moth eaten alopecia are characteristic feature of LPP scarring and can be considered as the most important differentiating point between DLE and LPP.  The activity of the disease is mainly central in DLE lesions while the activity of LPP is mainly at the periphery of the scarring patch in the form of hyperkeratotic follicular papules [6].  The associated manifestation of other body regions also can help approach the diagnosis; The lesions in DLE commonly affect the sun exposed parts, particularly on the cheeks, nose and the ears [13,14] with typical discoid lesions, while LPP lesions, as demonstrated by the present work, commonly present with a symptomatic truncal follicular papules which might be scarring or not (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

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Lichen Planopilaris is a Common Scarring Alopecia among Iraqi Population

Sharquie¹,

Noaimi²,

Hameed³

2013

JCDSA

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Background: Scarring alopecia like discoid lupus erythematosus, lichenplanopilaris and scarring folliculitis are common skin problems where differentiations between them are often difficult in many cases. Objective: To report, study and evaluate cases of lichen planopilaris and characterize the different clinical points in favor of this disease. Patients and Methods: This case series descriptive study was done at Department of Dermatology-Baghdad Teaching Hospital from January 2010 to November 2012. Sixty seven patients were included where histological and dermatological examinations were carried out to all patients regarding all relevant points related to the disease. Punch biopsies were performed from ten patients for histopathological study. Results: The mean age of onset of the disease was 36.7 ± 5 years with a mean duration of the disease being 4.4 ± 3 years. The male to female ratio was 1.4:1. The characteristic lesions were pigmented scarring moth eaten alopecia surrounded by pigmented hyperkeratotic follicular papules involving mainly the fronto-vertical and parietal scalp. Conclusions: Lichen planopilaris is a common cause of scalp scarring alopecia in adult and it has many characteristic clinical features which can facilitate differentiation from other pathologic scalp conditions like discoid lupus erythematosus.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Lichen Planopilaris is a Common Scarring Alopecia among Iraqi Population

Sharquie¹,

Noaimi²,

Hameed³

2013

JCDSA

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“…Nadir görülen bir hastalık olup, tüm alopesilerin %1,25'ini, sikatrisyel alopesilerin ise %25'ini oluşturur 2,3 . Hastalığın klasik LPP, Graham-Little sendromu ve frontal fibrozan alopesi (FFA) olmak üzere 3 klinik formu vardır 1,4 .…”

Section: Introductionunclassified

“…Daha nadir olmakla birlikte dallanan damarlar, pigment ağı, beyaz yama, pili torti ve pembebeyaz görünüm de izlenmişti. LPP'nin kesin tanısı histopatolojik inceleme ile konur [3][4][5][6] . Skalp biyopsi örneklerinin değerlendirmesinde kullanılan transvers ve vertikal kesitlerin tanısal açıdan farklı üstünlükleri vardır 22,23 .…”

Section: Introductionunclassified

Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

Özcan¹,

Seckın²,

Güleç³

et al. 2015

TURKDERM

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Background and Design: Lichen planopilaris (LPP) is a type of cicatricial alopecia characterized by autoreactive lymphocytic destruction of the hair follicle. We aimed to evaluate the demographic, clinical and histopathological features, and treatment outcomes of patients with LPP. Materials and Methods: Medical reports of 25 patients, who have been diagnosed with LPP according to the clinical and histopathological findings between January 2006 and June 2012, were retrospectively reviewed. The transverse and vertical sections of scalp biopsy specimens were re-evaluated by a pathologist, and the findings were noted. Results: Of the 25 patients, 18 were female and 7 were male, the mean age was 49.8±12.4 years. Eighteen patients had been diagnosed with classic LPP and 7 patients with frontal fibrosing alopecia (FFA). The alopecia has begun in postmenopausal period in 5 patients with FFA. Alopecia was associated with pruritus, pain and/or burning in 19 patients. Extra-scalp involvement was observed in 11 patients. The most common clinical findings were follicular hyperkeratosis (92%), perifollicular erythema (48%), perifollicular lichenoid papules, and positive hair-pull test (44%). Dermatoscopic examination was performed in 14 patients, and most commonly, absence of follicular openings (100%), perifollicular scales (92.9%) and perifollicular erythema (50%) were noted. The most common diagnostic histopathological findings were follicular vacuolar and lichenoid degeneration (88%) and vacuolar and lichenoid interface changes (56%). Twenty-three patients who were started on treatment received topical, intramuscular and intralesional corticosteroids, topical minoxidil, oral tetracycline, cyclosporine A, and hydroxychloroquine either alone or in combination. Progression of alopecia was prevented and the symptoms and/or signs were reduced in 12 (75%) of 16 patients whose follow-up data were available. Conclusion: LPP can be diagnosed accurately through a detailed clinical examination, dermatoscopy and histopathological examination. The symptoms and/or signs can be reduced and progression of the disease can be prevented with treatment.

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Acquired Disorders of Hair

Harries,

Holmes,

McMichael

et al. 2024

Rook's Textbook of Dermatology

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This chapter reviews acquired hair disorders, including common scarring and non‐scarring alopecia presentations, conditions characterised by excessive body hair growth and acquired hair shaft disorders. We also describe the biology of normal hair follicles, including structure, hair cycle control and immunity, to better understand the mechanisms underlying these conditions. We present methods for clinical assessment, recommended investigation and management of each disease, and present summaries of frequently used therapeutics and cosmetic options employed when treating these problems.

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Primary cicatricial alopecias: clinicopathology of 112 cases

Cited by 221 publications

References 29 publications

Lichen Planopilaris is a Common Scarring Alopecia among Iraqi Population

Lichen Planopilaris is a Common Scarring Alopecia among Iraqi Population

Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

Acquired Disorders of Hair

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