Primary cutaneous adenosquamous carcinoma of the penis: the first characterization of <scp>HPV</scp> status in this rare and diagnostically challenging entity with review of glandular carcinomas of the penis

Rush, Patrick S.; Shiau, Jonathan; Hibler, Brian P.; Longley, B. Jack; Downs, Tracy M.; Bennett, Daniel

doi:10.1111/cup.12835

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…At present, both entities are placed under the rubric of ASC. 34,35 Paget's disease of the penis (and scrotum) is a rare intraepidermal adenocarcinoma arising either as a primary tumour or by secondary involvement from an underlying malignancy in the genitourinary or gastrointestinal tract. Paget cells occur singly or in small clusters in the epidermis; however, 10-20% may have invasive tumour cells within the dermis.…”

Section: O T H E R E P I T H E L I a L T U M O U R Smentioning

confidence: 99%

“…They are invasive SCCs demonstrating either glandular and/or mucinous features, respectively. At present, both entities are placed under the rubric of ASC 34,35 . Paget's disease of the penis (and scrotum) is a rare intraepidermal adenocarcinoma arising either as a primary tumour or by secondary involvement from an underlying malignancy in the genitourinary or gastrointestinal tract.…”

Section: Invasive Epithelial Tumours Of Penismentioning

confidence: 99%

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WHO 2022 classification of penile and scrotal cancers: updates and evolution

et al. 2022

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cuniculatum or verrucous carcinoma with usual invasive SCC); in such cases, reporting of the relative percentages in mixed tumours may be useful. The consistent use of uniform nomenclature and reporting of percentages will inform the refinement of future reporting classification schemes and guidelines/recommendations.The classification of scrotal tumours is provided for the first time in the fifth edition of the WHO Blue book, and it follows the schema of penile cancer classification for both precursor lesions and the common SCC of the scrotum. Basal cell carcinoma of the scrotum may have a variable clinical course and finds a separate mention.

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Section: O T H E R E P I T H E L I a L T U M O U R Smentioning

confidence: 99%

Section: Invasive Epithelial Tumours Of Penismentioning

confidence: 99%

WHO 2022 classification of penile and scrotal cancers: updates and evolution

et al. 2022

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Tumor Microenvironment in Penile Cancer

Walter

2020

Advances in Experimental Medicine and Biology

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HPV-related diseases in male patients: an underestimated conundrum

Garolla,

Graziani,

Grande

et al. 2023

J Endocrinol Invest

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Purpose Human papillomavirus (HPV) infection is the most common sexually transmitted disease, in males and females worldwide. While the role of HPV in female diseases is well known and largely studied, males have negligibly been included in these programs, also because the proportion of women suffering and dying from HPV-related diseases is much larger than men. The aim of this review is to focus on HPV-related diseases in male patients. Methods We performed a literature analysis on the electronic database PubMed. We considered randomized trials, observational and retrospective studies, original articles having as topic the relationship between HPV male infection and the following items: oral, anal penile cancers, warts, condylomas, male infertility, altered sperm parameters, anti-sperm antibodies (ASA). We also included experimental in vitro studies focused on the effects of HPV infection on oocyte fertilization, blastocyst development, and trophoblastic cell invasiveness. In addition, studies describing the adjuvant administration of the HPV vaccination as a possible strategy to promote HPV clearance from semen in infected males were included. Results Regarding head and neck HPV-related diseases, the most important non-neoplastic disease is recurrent respiratory papillomatosis (RRP). Regarding neoplastic diseases, the proportion of head and neck cancers attributable to HPV has increased dramatically worldwide. In addition, nowadays, it is thought that half of head and neck squamous cell carcinomas (HNSCCs) cases in the United States are caused by infection with high-risk HPV. HPV is noteworthy in andrological practice too. It was described as having a high HPV prevalence, ranging between 50 and 70%, in male penile shaft, glans penis/coronal sulcus, semen as well as in scrotal, perianal, and anal regions. Moreover, in male patients, HPV infection has been associated, among other diseases, with penile cancers. HPV semen infection has been reported in about 10% in men from the general population and about 16% in men with unexplained infertility, although these data seem widely underestimated according to clinical experience. In particular, HPV semen infection seems to be most related to asthenozoospermia and to anti-sperm antibodies (ASAs). Conclusions HPV infection represents a health problem with a detrimental social and public impact. Despite this evidence, little has been done to date to widely promote vaccination among young males.

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Primary cutaneous adenosquamous carcinoma of the penis: the first characterization of HPV status in this rare and diagnostically challenging entity with review of glandular carcinomas of the penis

Cited by 7 publications

References 19 publications

WHO 2022 classification of penile and scrotal cancers: updates and evolution

WHO 2022 classification of penile and scrotal cancers: updates and evolution

Tumor Microenvironment in Penile Cancer

HPV-related diseases in male patients: an underestimated conundrum

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