Primary cutaneous aggressive epidermotropic CD8 positive cytotoxic T-cell lymphoma of the ear

Fika, Z; Karkos, Petros D.; Badran, Khaled; Williams, Richard

doi:10.1017/s0022215106005457

Cited by 24 publications

(22 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, phenotypic analysis of T-cell subpopulations is not crucial for the diagnosis of SMPTCL, and phenotypic variations have been described. [3][4][5] In our series as well as in most reported cases of SMPTCL, patients presented mostly with solitary lesions located in the majority of cases on the head and neck or trunk, but onset of multiple plaques and tumors has been described as well. [9][10][11][12][13][14][15][16][17] The histopathologic hallmark of SMPTCL is dense infiltrates of small-/medium-sized pleomorphic T lymphocytes with a small proportion of large cells (not exceeding 30%).…”

Section: Discussionsupporting

confidence: 59%

“…Neoplastic cells are characterized by a CD3 + /CD4 + /CD8 2 / CD30 2 phenotype, although CD8 + cases have been described. [3][4][5] The clinical outcome is usually favorable, with an estimated 5-year survival of 60%-80%. 1 We analyzed clinicopathologic features of 136 patients with skin lesions consistent with a diagnosis of SMPTCL to better understand this elusive group of cutaneous lymphoid proliferations.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Cutaneous CD4+ Small-/Medium-Sized Pleomorphic T-Cell Lymphoma: A Cutaneous Nodular Proliferation of Pleomorphic T Lymphocytes of Undetermined Significance? A Study of 136 Cases

Beltraminelli¹,

Leinweber²,

Kerl³

et al. 2009

The American Journal of Dermatopathology

197

224

View full text Add to dashboard Cite

Patients with skin nodules characterized by the infiltrate of pleomorphic small/medium T lymphocytes are currently classified as "primary cutaneous CD4+ small-/medium-sized pleomorphic T-cell lymphoma" (SMPTCL) or as T-cell pseudolymphoma. The distinction is often arbitrary, and patients with similar clinicopathologic features have been included in both groups. We studied 136 patients (male:female = 1:1; median age: 53 years, age range: 3-90 years) with cutaneous lesions that could be classified as small-/medium-sized pleomorphic T-cell lymphoma according to current diagnostic criteria. All but 3 patients presented with solitary nodules located mostly on the head and neck area (75%). Histopathologic features were characterized by nonepidermotropic, nodular, or diffuse infiltrates of small- to medium-sized pleomorphic T lymphocytes. A monoclonal rearrangement of the T-cell receptor-gamma gene was found in 60% of tested cases. Follow-up data available for 45 patients revealed that 41 of them were alive without lymphoma after a median time of 63 months (range: 1-357 months), whereas 4 were alive with cutaneous disease (range: 2-16 months). The incongruity between the indolent clinical course and the worrying histopathologic and molecular features poses difficulties in classifying these cases unambiguously as benign or malignant, and it may be better to refer to them with a descriptive term such as "cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance," rather than forcing them into one or the other category. On the other hand, irrespective of the name given to these equivocal cutaneous lymphoid proliferations, published data support a nonaggressive therapeutic strategy, particularly for patients presenting with solitary lesions.

show abstract

Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Primary Cutaneous CD4+ Small-/Medium-Sized Pleomorphic T-Cell Lymphoma: A Cutaneous Nodular Proliferation of Pleomorphic T Lymphocytes of Undetermined Significance? A Study of 136 Cases

Beltraminelli¹,

Leinweber²,

Kerl³

et al. 2009

The American Journal of Dermatopathology

197

224

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][7][8][9][10][11][12][13][14][15][16][17] Clinically, the disease manifests as localized or disseminated papules, papules, nodules, and tumors, often with ulceration, hemorrhage, and necrosis, or with superficial hyperkeratotic patches and plaques. [1][2][3][4][5][7][8][9][10][11][12][13][14][15][16][17] Unlike classic MF, patients do not generally have long-standing precursor lesions and do not follow the typical progression through patch-, plaque-, and finally tumor-stage disease, but rather present from the onset with widespread plaque-and tumor-stage disease. 3,9,12 Involvement of mucosal surfaces, and acrally accentuated lesions of the palms and soles, is commonly seen.…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma

Gormley

Hess

Anand

et al. 2010

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“…[5][6][7][8] In people, MF is the most common type of cutaneous T-cell lymphoma and accounts for more than 50% of all primary cutaneous lymphoma. 26 It is a proliferative disorder of CD4 show intraepithelial clustering of lymphocytes, known as Pautrier microabscess.…”

mentioning

confidence: 99%

Perforin Expression in Feline Epitheliotropic Cutaneous Lymphoma

2008

View full text Add to dashboard Cite

Abstract. Cutaneous lymphomas are uncommon in people and companion animals. The tumors can be broadly categorized into epitheliotropic and nonepitheliotropic forms, which appear to have different biological behaviors. The present case describes a feline cutaneous epitheliotropic lymphoma. Masses in a 9-year-old cat were first identified on the tail. The cat was treated with chemotherapy, but additional skin masses developed on the flank, face, and ears. Local radiation induced transient tumor regression, but eventual dissemination prompted euthanasia 13 months after initial tumor appearance. Granular lymphocytes were consistently detected on blood smears, and histologically, the tumor involved the skin and superficial subcutis. Tumor lymphocytes expressed cluster of differentiation 3 (CD3) and perforin molecules, suggestive of a cytotoxic phenotype. Location, histopathological features, and perforin expression were similar to a distinct entity in human medicine designated primary cutaneous, CD8-positive, epidermotropic, cytotoxic, T-cell lymphoma.

show abstract

Primary cutaneous aggressive epidermotropic CD8 positive cytotoxic T-cell lymphoma of the ear

Cited by 24 publications

References 2 publications

Primary Cutaneous CD4+ Small-/Medium-Sized Pleomorphic T-Cell Lymphoma: A Cutaneous Nodular Proliferation of Pleomorphic T Lymphocytes of Undetermined Significance? A Study of 136 Cases

Primary Cutaneous CD4+ Small-/Medium-Sized Pleomorphic T-Cell Lymphoma: A Cutaneous Nodular Proliferation of Pleomorphic T Lymphocytes of Undetermined Significance? A Study of 136 Cases

Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma

Perforin Expression in Feline Epitheliotropic Cutaneous Lymphoma

Contact Info

Product

Resources

About