Primary cutaneous apocrine carcinoma presenting as carcinoma erysipeloides

Abstract

References1 Smith F. The molecular genetics of keratin disorders. Am J Clin Dermatol 2003; 4:347-64. 2 Lane EB, McLean WHI. Keratins and skin disorders. J Pathol 2004; 204:355-66. 3 Ishida-Yamamoto A, McGrath JA, Judge MR et al. Selective involvement of keratins K1 and K10 in the cytoskeletal abnormality of epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma). J Invest Dermatol 1992; 99:19-26. 4 Rothnagel JA, Traupe H, Wojcik S et al. Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens. Nat Genet 1994; 7:485-90. 5 Kremer H, Zeeuwen P, McLean WHI et al. Ichthyosis bullosa of Siemens is caused by mutations in the keratin 2e gene. J Invest Dermatol 1994; 103:286-9. 6 McLean WHI, Morley SM, Lane EB et al. Ichthyosis bullosa of Siemens -a disease involving keratin 2e. J Invest Dermatol 1994; 103:277-81. 7 Akiyama M, Tsuji-Abe Y, Yanagihara M et al. Ichthyosis bullosa of Siemens: its correct diagnosis facilitated by molecular genetic testing. Br J Dermatol 2005; 152:1353-6. 8 Traupe H, Kolde G, Hamm H, Happle R. Ichthyosis bullosa of Siemens: a unique type of epidermolytic hyperkeratosis. J Am Acad Dermatol 1986; 14:1000-5. 9 Yang JM, Nam K, Kim HC et al. A novel glutamic acid to aspartic acid mutation of the 2B rod domain in the keratin 1 chain in epidermolytic hyperkeratosis. J Invest Dermatol 1999; 112:376-9. 10 Sun XK, Ma LL, Xie YQ et al. Keratin 1 and keratin 10 mutations causing epidermolytic hyperkeratosis in Chinese patient. J Dermatol Sci 2002; 29:195-200.Conflicts of interest: none declared. Fig 1. A well-demarcated, erythematous plaque with firm woody oedema involving the cheeks, chin and anterior neck.

Histiocytoid and signet-ring cell carcinoma of the axilla: a type of cutaneous apocrine carcinoma equivalent to histiocytoid lobular carcinoma of the breast?

“…The lack of expression of both oestrogen and progesterone receptors seen in the present case, and in some previously reported cases of cutaneous histiocytoid/SRC carcinoma, 3,4 may be expected, because these receptors have a tendency to be lost in poorly differentiated CAC and histiocytoid LC of the breast 7,9 . Interestingly, HER2 expression was present in our patient’s tumour (as in histiocytoid LC of the breast); there has been only one previous case report of CAC showing HER2 expression, which was histopathologically poorly differentiated 10 …”

“…7,9 Interestingly, HER2 expression was present in our patient's tumour (as in histiocytoid LC of the breast); there has been only one previous case report of CAC showing HER2 expression, which was histopathologically poorly differentiated. 10 There are no standard guidelines for optimum treatment of CAC. We gave our patient adjuvant FEC chemotherapy to treat this node-positive, locally invasive CAC, based on the general guidelines for treatment of breast carcinoma (including breast cancer in male patients), because of the histopathological similarity between CAC and breast carcinoma.…”

Cutaneous Appendageal Carcinoma Incidence and Survival Patterns in the United States

“…Our findings on the anatomic distribution contrast with some of the scant reports in the literature. 1,10,11,15,[37][38][39] Apocrine-eccrine carcinoma subtypes occurred with unique site distributions. Adenoid cystic carcinoma occurred most commonly on the face (43%), though it has been previously reported most frequently on the scalp (35%) or the trunk (24%).…”

A clinical, pathological and immunohistochemical series of 9 cases of primary cutaneous apocrine carcinomas of the head and neck

“…Older males were most commonly affected and, in line with literature, the scalp is the preferred site of presentation of the head and neck region. Apocrine carcinoma may appear as erythematous to violaceous papules or nodules and, remarkably, masquerading as cellulitis . In our series, clinical presentation mostly resembled a basal cell carcinoma due to the onset of a solitary nodule on sun‐exposed areas, usually exhibiting a reddish and fleshy appearance (Fig.…”