Primary cutaneous aspergillosis

Primary Gangrenous Cutaneous Mold Infections in a Patient with Cancer and Neutropenia

“…32 Penetrating trauma remains the major cause of primary cutaneous zygomycosis (Table 2). [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Other causes reported include elasticized bandages and wound dressings, 55 burns, 56 motor vehicle collision, 57 intravenous access, 58 and dog bite. 59 Our case report of primary cutaneous mucormycosis after a cat bite is a rare finding.…”

“…66 The higher overall mortality rate of 29.4% seen in the review of the literature was observed more frequently in patients with neutropenia (60.0%) and without surgical intervention (73.3%), and the survival rate was higher (35.3%) for cases utilizing both antifungal and surgical interventions. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] The antifungal agent with the highest survival rate was amphotericin B and its formulations (58.8%). [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] …”

“…[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] In patients with hematological malignancy and primary cutaneous mold infection, outcomes were determined on whether or not the infection was localized vs disseminated. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] In cases in which the infection remained localized, 100% of patients recov- ered; by contrast, in cases of disseminated infection, the mortality rate was 29.4%. [5][6][7][8][9][10][11][12][13][14][15][16][17]…”

Cutaneous aspergillosis

“…Although most of these patients had leukemia as the underlying oncologic diagnosis, reports have described other diseases, including aplastic anemia (2,51,66), astrocytoma (38), chronic granulomatous disease (14), and agranulocytosis treated with antithymocyte globulin (45). In greater than 85% of cancerrelated cases, primary cutaneous aspergillosis was associated with intravenous catheters, arm boards, or tape securing arm boards (2,9,11,17,22,25,37,38,51,68). Other associations have included breaks in the epithelium during insertion of a vaginal clotrimazole troche (53) and phlebotomy (34).…”

“…Previous reports have described cutaneous aspergillosis as either primary (2,17,25,38) or secondary (15,19) infection. Primary cutaneous aspergillosis usually involves sites of skin injury, namely, at or near intravenous access catheter sites, at sites of traumatic inoculation, and at sites associated with occlusive dressings, burns, or surgery.…”