Primary cutaneous B-cell lymphoma: A clinically homogeneous entity?

Pimpinelli, Nicola; Santucci, Marco; Mori, Moira; Vallecchi, C; Giannotti, B.

doi:10.1016/s0190-9622(97)70090-2

Cited by 49 publications

(26 citation statements)

References 41 publications

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“…Primary cutaneous B-cell lymphomas are less common than Tcell lymphomas and account for less than 20% of all primary cutaneous non-Hodgkin's lymphomas and are classified according to their cell of origin. 2 The precise mechanisms of lymphoma genesis are still obscure. It appears that various factors are involved including environmental, infectious agents, chromosomal translocations, insertions, or point mutations resulting from genetic instability of tumor cells.…”

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confidence: 99%

Frequent β-catenin overexpression without exon 3 mutation in cutaneous lymphomas

et al. 2004

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b-Catenin is a ubiquitously cytoplasmic protein that has a critical role in embryonic development and mature tissue homeostasis through its effects on E-cadherin-mediated cell adhesion and Wnt-dependent signal transduction. Mutations that alter specific b-catenin residues important for GSK-3b phosphorylation, or increase the half-life of the protein, were identified in human cancer. However, the role of the Wnt pathway in B-and T-cell oncogenesis has not been extensively investigated. To assess the role of b-catenin defects in primary cutaneous lymphomas, we examined the expression pattern and the genetic alteration of b-catenin on 79 samples from 74 patients with primary cutaneous lymphomas from B-and T-cell origin. Immunohistochemical analysis revealed b-catenin deregulation in five primary cutaneous B-cell lymphomas (21%) and in 21 primary cutaneous T-cell lymphomas (42%) without nuclear accumulation suggesting that activation and accumulation of b-catenin may play an important role in the development of skin lymphomas. Mutation analysis of b-catenin exon 3, which included the responsible element for Wnt signaling, was therefore done in 19 samples. However, genetic alterations of b-catenin exon 3 were not detected in any of these cases suggesting that other regulatory mechanisms may be relevant in activating b-catenin signaling in cutaneous lymphomas.

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confidence: 99%

Frequent β-catenin overexpression without exon 3 mutation in cutaneous lymphomas

et al. 2004

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“…In low grade CBCL, conversely, we usually found CD35+ follicular dendritic cells, with a stronger staining in cryostat sections, while the expression of CD21 is AE in cryostat sections and often lacking in paraffin sections. Indeed, we have previously stressed this ''aberrancy'' of dendritic cells in neoplastic follicle-like clusters of classic CBCL [15][16][17][18]29,30]. Therefore, it is not unlikely that immunologically aberrant follicular dendritic cells have a substantially downregulated expression of BCA-1 in both low grade CBCL and low grade gastric lymphoma of the MALT type.…”

Section: Discussionmentioning

confidence: 97%

“…The clinico-pathological features of primary cutaneous B-cell lymphomas (CBCL) are extensively dealt with elsewhere in Refs. [15][16][17][18]. In short, CBCL are mostly characterised by a homogeneous clinical presentation and behaviour, with a good response to local radiotherapy, low tendency to extracutaneous spread and excellent prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…An alternative possibility of a unitary interpretation of low grade CBCL has been suggested. In fact, we have documented that the histological pattern in CBCL is largely related to the age and growth rates of the skin lesions [15][16][17][18], with a characteristic multiphasic progression of the histological/immunohistological pattern from ''early'' (patchy/nodular infiltrate, with distinct compartmentalisation of neoplastic, small-medium centrocyte-like B-cells and reactive T-cells, that are often prominent) to ''late'' phases (diffuse infiltrate of neoplastic, large transformed centrocyte-like B-cells, with few admixed reactive T-cells). These multiphasic histological features have no correlation with either the clinical course or the prognosis of the disease.…”

Section: Introductionmentioning

confidence: 99%

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BCA-1, A B-cell chemoattractant signal, is constantly expressed in cutaneous lymphoproliferative B-cell disorders

Mori

Manuelli

Pimpinelli

et al. 2003

European Journal of Cancer

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We analysed the immunophenotypic and molecular expression of BCA-1 (B-cell-specific chemokine) and CXCR5 (BCA-1 receptor) in normal skin and different cutaneous lymphoproliferative disorders (cutaneous T-cell lymphoma (CTCL); cutaneous B-cell lymphoma (CBCL); cutaneous B-cell pseudolymphoma (PCBCL)), with the aim of investigating their possible involvement in the pathogenesis of cutaneous B-cell disorders. BCA-1 and CXCR5 were constantly expressed in CBCL and PCBCL, but not in normal skin and CTCL. BCA-1 and CXCR5 were constantly coexpressed by CD22+ B-cells, while CD35+ follicular dendritic cells coexpressed BCA-1 in PCBCL cells only. In low grade CBCL, as compared with high grade CBCL, the intensity of CXCR5 expression on neoplastic CD22+ cells was lower than that of BCA-1. The image analysis of reverse transcriptase-polymerase chain reaction (RT-PCR) products showed a significant quantitative difference between PCBCL/low grade CBCL and high grade CBCL. The above findings, although only observed in a small series of patients, are in keeping with findings in MALT gastric and gastric MALT lymphomas, adding further evidence of the close similarities between CBCL and MALT lymphomas. #

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“…Primary cutaneous large B-cell lymphomas (PCLBCL) represent a heterogeneous group of B-cell neoplasms which present in the skin without evidence of extracutaneous disease [1,2]. Classification of PCLBCL has been a matter of ongoing debate.…”

Section: Discussionmentioning

confidence: 99%

EBV positivity in primary cutaneous large B-cell lymphoma with immunophenotypic features of leg type: An isolated incidence or something more significant?

et al. 2008

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Primary cutaneous B-cell lymphoma: A clinically homogeneous entity?

Cited by 49 publications

References 41 publications

Frequent β-catenin overexpression without exon 3 mutation in cutaneous lymphomas

Frequent β-catenin overexpression without exon 3 mutation in cutaneous lymphomas

BCA-1, A B-cell chemoattractant signal, is constantly expressed in cutaneous lymphoproliferative B-cell disorders

EBV positivity in primary cutaneous large B-cell lymphoma with immunophenotypic features of leg type: An isolated incidence or something more significant?

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