Primary cutaneous CD30+ anaplastic large cell lymphoma treated with radiotherapy and methotrexate with development of xanthomas at the sites of prior disease

Abstract

Primary cutaneous anaplastic large cell lymphoma is a rare type of cutaneous T-cell lymphoma, and the involvement of the ocular adnexa is extremely rare. Secondary xanthoma-like changes after radiation therapy or chemotherapy have been rarely reported in association with large-cell T-cell anaplastic lymphoma. We report one case of a primary C-anaplastic large cell lymphoma affecting the eyelid with fast progression with multiple nodules in various anatomic sites and development of xanthoma-like lesions after treatment.

Evaluation of treatment results in multifocal primary cutaneous anaplastic large cell lymphoma: report of the Dutch Cutaneous Lymphoma Group

“…suggested that low‐dose MTX is an effective and well‐tolerated treatment in patients with primary cutaneous CD30‐positive lymphoproliferative disorders, but only four of the 45 patients included in that study had typical (multifocal) C‐ALCL . In addition, few case reports described CRs or PRs in patients with multifocal C‐ALCL . In the present study seven patients were treated with low‐dose MTX, including four with more than five lesions.…”

“…11 In addition, few case reports described CRs or PRs in patients with multifocal C-ALCL. [12][13][14][28][29][30] In the present study seven patients were treated with low-dose MTX, including four with more than five lesions. Four patients obtained a CR or PR (ORR 57%) during maintenance therapy with MTX, whereas three patients experienced insufficient effect.…”

Posttransplant Cutaneous Anaplastic Large Cell Lymphoma

“…Anaplastic large cell lymphoma (ALCL) is a rare and aggressive peripheral T-cell non-Hodgkin's lymphoma belonging to the group of CD30-positive lymphoproliferative syndromes [3]. (ALCL) accounts for approximately 3% of adult non-Hodgkin's lymphomas and 10-20% of childhood lymphomas.…”

CD30+ Cutaneous Anaplastic Large-Cell Lymphoma of the Upper Eyelid: A Case Report

“…In this case, the lesion was located on the upper eyelid, which is a very uncommon location. In the literature, we found only 12 cases of CD30+ cutaneous ALCL involving the eyelid [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Only 5% of ocular adnexal lymphomas involve the eyelid, among which only 44% are of T-cell origin, most frequently represented by mycosis fungoides (13%), high-grade extranodal natural killer/T-cell lymphoma (6%), and low-grade primary cutaneous ALCL (6%) [ 13 ].…”