Primary cutaneous CD30‐positive anaplastic large cell lymphoma. Report of 27 cases

Abstract

The clinical, morphological and immunohistochemical features of 27 patients with anaplastic large cell lymphoma (ALCL) of CD30-positive type, with cutaneous lesions as the sole initial clinical manifestation, were analyzed. The neoplasm presented as solitary or multiple, usually ulcerated skin lesions, affecting predominantly elderly patients (median age: 67 years) with a male preponderance (male to female ratio of 6:1). In most patients, there was an excellent response to chemotherapy. The cardinal histological features included diffuse dermal and subcutaneous infiltration by large, anaplastic tumor cells, all or nearly all of which showed diffuse, strong membrane staining and frequently a paranuclear, dot-like reaction with the CD30 marker (Ber-H2). Epidermal ulceration, pseudo-epitheliomatous hyperplasia and dermal vascular proliferation were also observed.

Ki-1-Positive Large-Cell Cutaneous Lymphoma Mimicking a Stewart-Treves Angiosarcoma

“…Ulceration is also fre quent [9,10], as in the series of Krishnan et al [11 ], Banerjee et al |3] and more recently Beljaards et al [7], but erythroderma is exceptional [5]. The vascular proliferation of the lesion in our patient may account for its deceptive aspect, with contact bleeding.…”

Prognostic Factors in Primary Cutaneous Anaplastic Large Cell Lymphoma

“…Overall, the clinical characteristics of our 48 patients are consistent with those of previous studies at other institutions worldwide, confirming that pcALCL as a group is associated with a favorable prognosis. 2,3,[15][16][17] However, to our knowledge this is also the first report that describes a subset of patients with ELD who had a worse treatment and survival outcome compared with patients with pcALCL but without ELD (typical pcALCL).…”

Proliferación tumoral en brazo derecho

“…Las lesiones ulceradas muestran generalmente una hiperplasia epidérmica y un abundante infiltrado conformado por linfocitos, plasmocitos y polimorfonucleares. 7,8,9 El estudio inmunohistoquímico complementario muestra una intensa positividad para CD 30, CD 3 y CD 4. Algunas veces la expresión de antígenos Pan T puede estar parcial o totalmente perdida.…”