Primary Cutaneous Diffuse Large B-Cell Lymphoma With KMT2A-MLLT3: An Infantile Case Study

Hiroki, Haruka; Yoshimi, Ai; Kato, Keisuke; Yanai, Toshiro; Koike, Kenichi

doi:10.1097/mph.0000000000001527

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…9 The pediatric case demonstrated poor response to mature B-cell lymphoma-specific chemotherapy and was in remission after high-dose cytarabine and oral maintenance chemotherapy with 6-mercaptopurine and methotrexate. 10 This difference in therapeutic response between the adult and pediatric cases, including our patient, may be attributed to differences in their genetic background. However, previous reports have not identified genetic alterations other thanKMT2A rearrangement.…”

Section: Discussionmentioning

confidence: 75%

“…KMT2A -rearranged DLBCL has been reported in two adults and one child. 9,10 The adults maintained remission after R-CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab). 9 The pediatric case demonstrated poor response to mature B-cell lymphoma-specific chemotherapy and was in remission after high-dose cytarabine and oral maintenance chemotherapy with 6-mercaptopurine and methotrexate.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8] KMT2A -rearranged DL-BCL can be detected in a few adult and pediatric patients. 9,10 Herein, we describe a pediatric case of KMT2A -rearranged DLBCL. We performed RNA sequencing (RNAseq) to understand the molecular biology of KMT2A -rearranged DLBCL.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

KMT2A-rearranged diffuse large B-cell lymphoma in a child: a case report and molecular characterization

Kato

Kubota

Sekiguchi

et al. 2020

Preprint

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A 19-month-old female with a right temporal bone tumor was diagnosed with diffuse large B-cell lymphoma by tumor biopsy. Leukemic conversion occurred after chemotherapy for mature B-cell lymphoma. Additional chemotherapy was unsuccessful and resulted in death of the patient owing to disease progression. We detected the KMT2A-MLLT3 fused transcript in the bone marrow of the patient with primary and recurrent cancer. RNA sequencing of the bone marrow with recurrent cancer showed similarities with KMT2A-rearranged leukemia, such as overexpression of MEIS1 and MEF2C, which was attributable to the aggressive course.

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Section: Discussionmentioning

confidence: 75%