2012
DOI: 10.5858/arpa.2012-0195-ra
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Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type: Diagnostic Considerations

Abstract: Context.—Primary cutaneous diffuse large B-cell lymphoma, leg type, may show features that overlap with other lymphomas. However, timely recognition of this entity can have important clinical and therapeutic implications. Objective.—To review the clinical, morphologic, and immunophenotypic characteristics of primary cutaneous diffuse large B-cell lymphoma, leg type, and juxtapose these features with other diagnostic considerations. In particular, other variants of primary cutaneous diffuse large… Show more

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Cited by 31 publications
(45 citation statements)
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“…[97077] Extracutaneous spreading is often reported, most commonly in lymph nodes, bone marrow, and nervous system. [78]…”
Section: Primary Cutaneous Diffuse Large B-cell Lymphoma Leg Typementioning
confidence: 99%
See 1 more Smart Citation
“…[97077] Extracutaneous spreading is often reported, most commonly in lymph nodes, bone marrow, and nervous system. [78]…”
Section: Primary Cutaneous Diffuse Large B-cell Lymphoma Leg Typementioning
confidence: 99%
“…This immunophenotype is useful for the diagnosis of PCDLBCL, LT even if 10% of cases are negative for BCL-2 and MUM1/IRF4. [767882]…”
Section: Primary Cutaneous Diffuse Large B-cell Lymphoma Leg Typementioning
confidence: 99%
“…The five-year survival is 50%. 3-5 Histological examination of tumor lesions shows a diffuse, monotonous cellular infiltrate of immunoblasts, without epidermotropism. The presence of the normal collagen band in the superficial dermis, separating the epidermis from the dermal lymphocytic infiltrate (Grenz zone) is a common finding in cutaneous B-cell lymphomas.…”
Section: Discussionmentioning
confidence: 99%
“…It accounts for a minority of primary cutaneous B-cell lymphomas. The most common site of involvement is the lower leg, although other cutaneous sites may be affected [23][24][25]. It usually presents as solitary, occasionally multiple, erythematous or violaceous nodules on one or both legs, often with ulceration.…”
Section: Primary Central Nervous System Diffuse Large B-cell Lymphomamentioning
confidence: 99%
“…These include heterozygous deletion of TNFAIP3 (A20), and mutations of CD79B, CARD11, and MYD88 resulting in amino acid substitutions, with more than one abnormality affecting a subset of cases [27]. The differential diagnosis of primary cutaneous DLBCL includes primary cutaneous follicle center lymphoma [25]. Cutaneous follicle center lymphoma is a proliferation of large and small centrocytes and centroblasts.…”
Section: Primary Central Nervous System Diffuse Large B-cell Lymphomamentioning
confidence: 99%