Primary cutaneous extraskeletal osteosarcoma under a previous electrodessicated actinic keratosis

Santos‐Juanes, Jorge; Galache, Cristina; Miralles, Manuel; Curto, JR; Río, José Sánchez del; Soto, Jaime

doi:10.1016/j.jaad.2004.04.021

Cited by 26 publications

(12 citation statements)

References 21 publications

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“…Primary cutaneous osteosarcoma is distributed equally in gender (7 men and 6 women). There have been described as possibly predisposing factors previously electrodesiccated actinic keratosis, 8,9 old burn scar area, 13 radiotherapy, 15 trauma, 5,12 and malignant melanoma. Age onset ranges from 51 to 96 years, with a mean of 71.3 years.…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Osteosarcoma of the Skin

Llamas‐Velasco

Rütten

Requena

et al. 2013

The American Journal of Dermatopathology

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Dermal or subcutaneous involvement of extraskeletal osteosarcoma is uncommon, and primary cutaneous osteosarcoma of the skin is even rarer, with only few cases well characterized. The authors present 2 cases of this infrequent skin neoplasm. A 76-year-old woman with a nodule on left malar area and an 82-year-old man with a hard nodule on the right temple. First patient's biopsy findings were a dermal lesion mostly composed of malignant osteoid material, with atypical rhabdoid cells intermingled, which was diagnostic of osteoblastic osteosarcoma. Excision of the lesion of the second patient showed a dermal proliferation of atypical spindle-shaped and pleomorphic cells, scattered multinucleated osteoclasts-like cells, and irregular malignant osteoid material. In some fields, atypical cells showed a pseudovascular pattern. Close to this exophytic lesion, a small nest of basal cell carcinoma was observed. Final diagnosis was collision of osteoblastic and telangiectatic primary osteosarcoma and superficial basal cell carcinoma. Both patients have not presented recurrence or metastatic disease after 12 and 9 months of follow-up, respectively. Clinical and histopathologic characteristics of the primary cutaneous osteosarcoma are summarized, and the differential diagnosis of this entity with other benign and malignant skin neoplasms, which can, eventually, show osteoid material.

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Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Osteosarcoma of the Skin

Llamas‐Velasco

Rütten

Requena

et al. 2013

The American Journal of Dermatopathology

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“…Irradiation can trigger development of osteosarcoma; 11 trauma also may have a role. Whether chemotherapy contributes to the development of metastases in osteosarcoma is not known.…”

Section: Discussionmentioning

confidence: 99%

“…ESOS has been described in patients who have no predisposing conditions 13–15 . It also has been described to occur in a previously electrodessicated actinic keratosis, 11 in an old burn scar area, 16 and in malignant melanoma 17 . Ram et al.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15] It also has been described to occur in a The following three criteria define classic Li-Fraumeni syndrome: (i) a sarcoma diagnosed before a proband is 45 years old, (ii) any cancer diagnosed in a first-degree relative before 45 years of age, and (iii) any cancer diagnosed in a first-or second-degree relative before 45 years of age or a sarcoma at any age. previously electrodessicated actinic keratosis, 11 in an old burn scar area, 16 and in malignant melanoma. 17 Ram et al 18 described several cases of primary cutaneous carcinosarcoma in which the sarcomatous component was osteosarcoma; after their publication, other cases of cutaneous carcinoma and osteosarcoma were discovered.…”

Section: Skin As the Primary Site Of Extraskeletal Osteosarcomamentioning

confidence: 99%

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Osteosarcoma of the skin

Larsen¹,

Davis²,

Comfere³

et al. 2010

Int J Dermatology

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“…Most of the previously reported cases of ESOS were situated deep in muscular, fascial or aponeurotic tissues, with only rare examples confined to the skin. Recently, Santos‐Juanes et al 16 collected eight cases of primary cutaneous osteosarcoma from the literature, to which they added one additional case 8,17–21 . Two single cases of osteosarcoma have also been reported as primary tumors in the scalp 22,23 .…”

Section: Discussionmentioning

confidence: 99%

Extraskeletal cutaneous chondroblastic osteosarcoma: a case report

Salamanca¹,

Dhimes²,

Pinedo³

et al. 2007

J Cutan Pathol

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Extraskeletal osteosarcoma is an uncommon neoplasm that usually arises in the deep soft tissues, especially in the lower extremities, with rare cases involving the subcutis or dermis. We report a 60-year-old man with an enlarging cutaneous mass in the right lower thigh. An incisional skin biopsy showed a well-defined, but non-encapsulated neoplasm, characterized by extensive cartilage with marked cellularity, atypia and high mitotic activity, involving the dermis and subcutis. Although osteoid or bone was not observed, a diagnosis of cutaneous chondroblastic osteosarcoma was suggested after excluding an origin in bone or other primary tumor sites by imaging techniques. Histopathologic features of the surgical specimen were characteristic, with a predominant high-grade chondroid component together with focal fibrosarcomatous zones, areas of multinucleated giant cells and foci of bone and osteoid formation. The patient underwent postoperative chemotherapy and is currently alive with pulmonary metastases 15 months after surgery. In summary, we report a unique case of cutaneous osteosarcoma of the chondroblastic subtype, diagnosed on incisional skin biopsy despite the absence of osteoid or bone during tumor sampling. As a rule, when an obviously malignant 'chondrosarcoma' is identified, one should always consider this entity.

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Primary cutaneous extraskeletal osteosarcoma under a previous electrodessicated actinic keratosis

Cited by 26 publications

References 21 publications

Primary Cutaneous Osteosarcoma of the Skin

Primary Cutaneous Osteosarcoma of the Skin

Osteosarcoma of the skin

Extraskeletal cutaneous chondroblastic osteosarcoma: a case report

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