Primary cutaneous histoplasmosis in an immunocompetent patient presenting with severe pruritus

Patra, Suman; Nimitha, P; Kaul, Subuhi; Valakkada, Jineesh; Verma, Kaushal K.; Ramam, M; Bhari, Neetu

doi:10.4103/ijdvl.ijdvl_695_17

Cited by 9 publications

(4 citation statements)

References 4 publications

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“…Generalised pruritus as the only symptom of histoplasmosis is described in only one case report till now. [ 2 ] Several tests are available for diagnosis such as culture, microscopic examination, serology, antigen detection by ELISA and molecular methods. Urine histoplasma antigen detection is considered an initial screening test for suspected histoplasmosis because of its high sensitivity of up to 100%.…”

Section: Discussionmentioning

confidence: 99%

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‘Generalised Pruritus with Prurigo-Like Lesions and Generalised Lymphadenopathy: Could be an Early Diagnostic Clue for Angioimmunoblastic T-Cell Lymphoma (AITL) and/or Histoplasmosis’

Kumar,

Batra,

Budania

et al. 2023

Indian Journal of Dermatology

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Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon systemic lymphoproliferative disorder that comprises approximately one-fifth of all mature peripheral T-cell lymphomas. A broad range of cutaneous manifestations include maculopapular, papulovesicular, erythrodermic, urticarial, plaque-like and nodular, and they are mentioned in 50% of patients and may precede systemic symptoms, which include lymphadenopathy, hepatosplenomegaly and constitutional symptoms. Histoplasmosis is a common granulomatous infection worldwide caused by Histoplasma capsulatum, a dimorphic fungus. Cutaneous manifestations are reported to occur in 10% to 25% of immunosuppressed patients with disseminated histoplasmosis. Generalised pruritus as a presenting feature is rarely described in both of these entities. We report a unique case of AITL with histoplasmosis discovered during paraclinical assessment of generalised pruritus (? neurodermatitis) with prurigo-like lesions and lymphadenopathy.

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Section: Discussionmentioning

confidence: 99%

“…Generalised pruritus with prurigo-like lesions is rarely reported as a presenting symptom of histoplasmosis. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

‘Generalised Pruritus with Prurigo-Like Lesions and Generalised Lymphadenopathy: Could be an Early Diagnostic Clue for Angioimmunoblastic T-Cell Lymphoma (AITL) and/or Histoplasmosis’

Kumar,

Batra,

Budania

et al. 2023

Indian Journal of Dermatology

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“…Currently, only AmBisome® has been evaluated in the treatment of disseminated histoplasmosis [2,31]. Besides, some case reports have also stressed its clinical efficacy in the rare primary cutaneous form of the disease in immunocompetent patients [9][10][11].…”

Section: Lipid Formulations Of Amphotericin Bmentioning

confidence: 99%

“…The infection is caused by inhaling aerosols that contain the infecting particles of the dimorphic fungus, Histoplasma capsulatum and it affects most frequently the lung [8]. Nevertheless, it can also affect the skin [9][10][11], and the central nervous system (CNS) causing meningitis [12] or even evolve into a progressive disseminated infection that may trigger an inflammatory response and bring rheumatological and heart complications (pericarditis), with high morbidity rates [13,14].…”

Section: Introductionmentioning

confidence: 99%

Is Micro and Nanotechnology Helping Us Fight Histoplasmosis?

Filipa¹,

Domingos²,

Salette³

et al. 2023

Infectious Diseases

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Histoplasmosis is an airborne systemic infection, with varied clinical manifestations, from asymptomatic infection to disseminated disease with a deadly outcome. Due to a growing number of immunosuppressed people, this mycosis has become more prevalent and thus, a cause for concern within the medical community. In fact, this fungal infection can be quite serious for children, elderly, people who have had an organ transplant, HIV-positive or people taking immunosuppressants. There has been a limited number of research articles suggesting polymeric, metallic, or lipid micro and nanotechnology-based approaches as a potential way to carry antifungal drugs to treat histoplasmosis. These new drug delivery systems present a variety of means of administration, thereby allowing a more targeted treatment to the lungs, skin, or eyes, according to the infection site. In this review, the aim was to explore these new therapies that have been emerging which hold great potential in comparison to regular antifungal treatments, not only due to their safety but also due to their drug release profile.

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Multiple keratotic papulonodular lesions in a human immunodeficiency virus‐negative patient

Almutairi,

Alobaid,

Al‐Sabah

et al. 2024

JEADV Clinical Practice

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Primary cutaneous histoplasmosis in an immunocompetent patient presenting with severe pruritus

Cited by 9 publications

References 4 publications

‘Generalised Pruritus with Prurigo-Like Lesions and Generalised Lymphadenopathy: Could be an Early Diagnostic Clue for Angioimmunoblastic T-Cell Lymphoma (AITL) and/or Histoplasmosis’

‘Generalised Pruritus with Prurigo-Like Lesions and Generalised Lymphadenopathy: Could be an Early Diagnostic Clue for Angioimmunoblastic T-Cell Lymphoma (AITL) and/or Histoplasmosis’

Is Micro and Nanotechnology Helping Us Fight Histoplasmosis?

Multiple keratotic papulonodular lesions in a human immunodeficiency virus‐negative patient

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