Primary cutaneous lymphoma in Argentina: a report of a nationwide study of 416 patients

Abstract

Background The aim of this study was to determine the relative frequency of primary cutaneous lymphoma (PCL) in Argentina according to the new World Health Organization (WHO)-European Organization for the Research and Treatment of Cancer (EORTC) classification system.Methods A total of 416 patients from 21 dermatology services were included during a 5-year period (2010-2015); these patients were classified using WHO-EORTC criteria.Results There were 231 (55.2%) males and 185 (44.8%) females; the male-to-female ratio was 1.35. The median age of the patients was 57 years (range, 0-90 years). Most patients were Caucasian (79%), and only 16% of patients were registered as Amerindian. Most patients (387/416, 93%) had cutaneous T-cell lymphoma (CTCL); 28 patients (6.7%) were diagnosed with cutaneous B-cell lymphoma (CBCL). The most frequent CTCL subtypes, in decreasing order of prevalence, were mycosis fungoides (MF), including its variants (75.7%); CD30+ primary cutaneous lymphoproliferative disorders (7.2%); and S ezary syndrome (SS) (3.1%). Cutaneous follicle center lymphoma was the most common CBCL subtype (2.9%). In the subset of patients ≤20 years of age, the most common condition was MF (57%), followed by extranodal NK-T nasal-type lymphoma (14%). ConclusionsThis study revealed relatively higher rates of MF and lower rates of CBCL in Argentinean patients that have been reported in American and European countries.

Primary Cutaneous Lymphomas in Thailand: A 10-Year Retrospective Study

“…BioMed Research International reported worldwide [3-6, 8-10, 14-16]. This finding is consistent with those reported in studies from China (94.5%) [10], Iran (96%) [17], Argentina (93%) [16], and Taiwan (92.3%) [18], but relatively higher than those from Japan (85.7%) [8] and Korea (88%) [9]. Our study emphasizes that non-Caucasian populations appeared to have a higher proportion of CTCLs than those of Caucasian populations (USA, 72.4% [6]; Netherlands and Austria, 78% [4]; Germany, 85% [5]; Switzerland, 72% [15]; Italy, 78.7% [3]).…”

Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center

“…In two studies from Korea, the percentage of FMF in all MF patients accounted for around 2% and 4% respectively 19,20 . In a study in Argentina 21 , the portion was about 6%.…”

Epidemiology of Cutaneous T-Cell Lymphomas: A Systematic Review and Meta-Analysis of 16,953 Patients

“…In total, 16,953 patients from 26 different studies were enrolled in the present meta-analysis. The majority of the studies were reported in European populations; only one South American cohort [ 7 ] met the inclusion criteria, and none from Australia or Africa did. The publication dates were evenly distributed over two decades, however there was a gap between 2014 and 2018.…”

“…A mutational profile consistent with ultraviolet B exposure has been identified in CTCL [ 6 ], but a causal role of ultraviolet exposure in the occurrence of CTCL has not yet been demonstrated. Several epidemiological studies have been reported [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ], but no worldwide meta-analysis has been published to date.…”