Primary cutaneous marginal zone lymphomas with plasmacytic differentiation show frequent IgG4 expression

Brenner, I.; Roth, Sabine; Puppe, Bernhard; Wobser, Marion; Rosenwald, Andreas; Geissinger, Eva

doi:10.1038/modpathol.2013.106

Cited by 93 publications

(96 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These lymphomas are thought to be derived from the infiltrating IgG4-positive cells in patients with pre-existing IgG4-RD because they have background features such as dense fibrosis and a high serum level of IgG4 [10,17]. However, it is still controversial whether such IgG4-positive cells can clonally expand to form malignant lymphomas [18,19]. Brenner et al reported that 39 % of cutaneous marginal zone lymphomas immunohistochemically expressed IgG4 and concluded that there was little association between IgG4-producing lymphomas and IgG4-RD [19].…”

Section: Discussionmentioning

confidence: 97%

“…However, it is still controversial whether such IgG4-positive cells can clonally expand to form malignant lymphomas [18,19]. Brenner et al reported that 39 % of cutaneous marginal zone lymphomas immunohistochemically expressed IgG4 and concluded that there was little association between IgG4-producing lymphomas and IgG4-RD [19]. Since it is highly likely that this case of IgG4-producing marginal zone lymphoma occurred in a patient with IgG4-RD, a subset of IgG4-producing lymphomas might arise from pre-existing IgG4-RD.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

IgG4-producing lymphoma arising in a patient with IgG4-related disease

et al. 2016

View full text Add to dashboard Cite

We herein report a case in which an IgG4-producing lymphoma arose in a patient with a previous diagnosis consistent with an IgG4-related disease. A 43-year-old man presented with enlarged cervical lymph nodes and was treated with steroids and radiation for what was initially assumed to be Kimura's disease, although the lesions were later histologically re-diagnosed as IgG4-related lymphadenopathy. Fourteen years later, when the patient was 58-years-old, he presented with retroperitoneal fibrosis and swollen lymph nodes. The suspicious lesions were not histologically examined as the patient did not give consent. However, the serum IgG4 concentration was high (1400 mg/dL) and he was clinically diagnosed with systemic IgG4-related disease. Although steroid administration reduced the size of the lesions, tapering the dose finally resulted in systemic, prominently enlarged lymph nodes. Analysis of the biopsy specimen revealed that these multiple lymph node lesions were marginal zone B cell lymphomas that themselves expressed IgG4. Complete remission was achieved after a total of six courses of chemotherapy including rituximab. This case suggests that the infiltrating IgG4-expressing cells observed in IgG4-related disease can clonally expand to malignant lymphomas.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

IgG4-producing lymphoma arising in a patient with IgG4-related disease

et al. 2016

View full text Add to dashboard Cite

show abstract

“…2 Most noncutaneous MALT lymphomas express IgM, whereas PCMZLs usually express IgG, IgA, and IgE, 3 and a significant number of them express IgG4. 4 Rosai-Dorfman disease (RDD) (sinus histiocytosis with massive lymphadenopathy) is a rare, idiopathic histiocytic disorder involving lymph nodes and, in about one-fourth of the cases, other organs, including the skin, 5 and primary isolated cutaneous involvement has been considered a distinct entity. 6 An exaggerated immune response to an infectious agent or antigen has been proposed as the cause for the proliferation of histiocytes in RDD.…”

Section: Introductionmentioning

confidence: 99%

Primary Cutaneous Marginal IgG4 Lymphoma and Rosai–Dorfman's Disease Coexisting in Several Lesions of the Same Patient

Machan¹,

Medina

Rodríguez‐Pinilla

et al. 2015

The American Journal of Dermatopathology

View full text Add to dashboard Cite

We report the unique association of primary cutaneous marginal zone B-cell lymphoma and Rosai-Dorfman disease (RDD)-type histiocytic infiltrates involving the same lesions. The patient was an 82-year-old woman with 3 long-standing, well-circumscribed firm erythematous to brownish plaques on her left arm, right scapular area, and lumbosacral area. Histopathologic examination disclosed a dermal and subcutaneous nodular lymphoplasmacytic infiltrate with evidence of germinal center colonization and light-chain restriction and sheets of S-100 CD68-positive histiocytes with ample pale cytoplasm and occasional emperipolesis of lymphocytes. The neoplastic plasma cells expressed immunoglobulin (Ig) G4. A review of 14 examples of cutaneous RDD showed a substantial number of IgG4-positive cells in only 3 of them, and a review of 8 primary cutaneous marginal zone B-cell lymphomas disclosed only 2 with significant IgG4 expression. The coexistence of lymphomas and RDD has been rarely reported in the literature but only seldom involving the same lymph node and-to the best of our knowledge-never in the skin.

show abstract

“…36 In addition, a significant percentage of dural marginal zone lymphomas and cutaneous marginal zone lymphomas have been shown to produce IgG4 without a known association with IgG4-RD. 37,38 The association of IgG4-RD and lymphoma, as well as the significance of IgG4 production by lymphomas, both nodal and extranodal, will require additional and larger studies for clarification. 39,40 In the presence of increased IgG4-positive cells, the possibility of lymphoma or other malignancy needs to be excluded.…”

Section: Igg4-related Lymphadenopathymentioning

confidence: 98%