Primary cutaneous non-Hodgkin lymphoma: results of a retrospective analysis in the light of the recent ILROG guidelines

Pedretti, Sara; Urpis, Mauro; Leali, C; Borghetti, Paolo; Baushi, Liliana; Sala, Raffaella; Tucci, Alessandra; Greco, Diana; Pasinetti, Nadia; Triggiani, Luca; Rossi, Giuseppe; Calzavara‐Pinton, Piergiacomo; Magrini, Stefano Maria; Buglione, Michela

doi:10.5301/tj.5000606

Cited by 5 publications

(10 citation statements)

References 36 publications

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“…There are no randomized controlled data to guide treatment. In case of solitary and localized lesions, surgery and radiation therapy can be chosen for a curative therapeutic approach 6 . Radiotherapy is safe and effective for localized lesions 5,6 .…”

Section: Discussionmentioning

confidence: 99%

“…In case of solitary and localized lesions, surgery and radiation therapy can be chosen for a curative therapeutic approach 6 . Radiotherapy is safe and effective for localized lesions 5,6 . In advanced cutaneous lymphoma radiotherapy alone has a role in symptom palliation 6 .…”

Section: Discussionmentioning

confidence: 99%

“…Radiotherapy is safe and effective for localized lesions 5,6 . In advanced cutaneous lymphoma radiotherapy alone has a role in symptom palliation 6 . If lesions are only thin plaques, topical treatment with high-potency corticosteroids and intralesional administration of interferon alpha or rituximab can also be used 5 .…”

Section: Discussionmentioning

confidence: 99%

“…If lesions are only thin plaques, topical treatment with high-potency corticosteroids and intralesional administration of interferon alpha or rituximab can also be used 5 . In the case of multiple and symptomatic lesions systemic drug treatment is needed 5,6 . First choice in treatment of advanced disease is accepted as rituximab in most of the reports 5 .…”

Section: Discussionmentioning

confidence: 99%

“…Topical-intralesional medications, radiotherapy chemotherapy and surgery are some of the treatment options 5,6 .…”

Section: Introductionmentioning

confidence: 99%

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Diffuse large B-cell lymphoma, leg type: A case report

Ünlü¹,

Yazıcı²,

İkizoğlu³

et al. 2019

TURKDERM

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Diffüz büyük B hücreli lenfoma, bacak tipi, primer kütanöz lenfomaların nadir görülen, kötü prognozlu bir alt tipidir. Yetmiş dört yaşında kadın hasta, sol bacağında, 4 ay önce ortaya çıkan, hızlı büyüyen, şişlikler ve yaralar yakınmasıyla dermatoloji kliniğimize başvurdu. Tanı alınan deri biyopsi materyalinin histopatolojik inceleme ile konuldu. İyileşmeyen bacak ülserlerinde, nodül ve plak lezyonlarında, malign hastalıklardan şüphelenilerek biyopsi alınmalıdır.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Topical-intralesional medications, radiotherapy chemotherapy and surgery are some of the treatment options 5,6 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Diffuse large B-cell lymphoma, leg type: A case report

Ünlü¹,

Yazıcı²,

İkizoğlu³

et al. 2019

TURKDERM

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Breaking Down the Barriers for Patients With Cutaneous T-Cell Lymphoma: Current Controversies and Challenges for Radiation Oncologists in 2024

Campbell,

Prince,

Thursky

et al. 2025

Seminars in Radiation Oncology

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Light and shadows of a new technique: is photon total-skin irradiation using helical IMRT feasible, less complex and as toxic as the electrons one?

et al. 2018

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BackgroundRadiotherapy is one of the standard treatments for cutaneous lymphoma and Total Skin Electrons Beam Irradiation (TSEBI) is generally used to treat diffuse cutaneous lymphoma and some cases of localized disease. Helical IMRT (HI) allows to treat complex target with optimal dose distribution and organ at risk sparing, so helical tomotherapy has been proposed as alternative technique to TSEBI but only one preliminary report has been published.MethodsThree patients treated (from May 2013 to December 2014) with Helical IMRT, with a total dose between 24 and 30 Gy, were retrospectively evaluated. Data about dosimetric features, response and acute toxicity were registered and analyzed.Planned target coverage was compared with daily in vivo measures and dose calculation based on volumetric images used for set up evaluation as well.ResultsThe patients had a mean measured surface fraction dose ranging from 1.5 Gy up to 2.0 Gy. A planned target dose ranging from 85 to 120% of prescription doses was obtained. All doses to Organs At Risk were within the required constraints. Particular attention was posed on “whole bone marrow” planned V10Gy, V12Gy and V20Gy values, ranging respectively between 23 and 43%, 20.1 and 38% and 9.8 and 24%. A comparison with the theoretical homologous values obtained with TSEBI has shown much lower values with TSEBI.Even if treatment was given in sequence to the skin of the upper and lower hemi-body, all the patients had anaemia, requiring blood transfusions, leukopenia and thrombocytopenia.ConclusionBased on our limited results TSEBI should still be considered the standard method to treat total skin because of its pattern of acute and late toxicities and the dose distribution. In this particular case the better target coverage obtained with HI can be paid in terms of worse toxicity. Helical IMRT can instead be considered optimal in treating large, convex, cutaneous areas where it is difficult to use multiple electrons fields in relation with the clinical results and the limited and reversible toxicities.

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Primary cutaneous non-Hodgkin lymphoma: results of a retrospective analysis in the light of the recent ILROG guidelines

Cited by 5 publications

References 36 publications

Diffuse large B-cell lymphoma, leg type: A case report

Diffuse large B-cell lymphoma, leg type: A case report

Breaking Down the Barriers for Patients With Cutaneous T-Cell Lymphoma: Current Controversies and Challenges for Radiation Oncologists in 2024

Light and shadows of a new technique: is photon total-skin irradiation using helical IMRT feasible, less complex and as toxic as the electrons one?

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