Primary cutaneous phaeohyphomycosis

Noel, Stella Boustany; Greer, Donald L.; Abadie, Sandra M.; Zachary, James A.; Pankey, George A.

doi:10.1016/s0190-9622(88)70099-7

Cited by 29 publications

(12 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To differentiate from hyalohyphomycosis (nonpigmented hyphae), Masson-Fontana stain can be utilized to demonstrate pigment melanin in the fungus. [67] In our case both GMS stain and Masson-Fontana stain confirmed the diagnosis of phaeohyphomycosis.…”

supporting

confidence: 78%

Pheohyphomycotic cyst

Madke

Khopkar

2015

Indian Dermatol Online J

View full text Add to dashboard Cite

supporting

confidence: 78%

Pheohyphomycotic cyst

Madke

Khopkar

2015

Indian Dermatol Online J

View full text Add to dashboard Cite

“…The wall of the cyst is composed of dense fibrous tissue containing granulomatous reaction associated with scattered giant cells. Brown filamentous hyphae and yeast cells are seen in the wall on special staining, such as Gomori's methenamine silver (GMS) or Masson–Fontana stain 7 . In some cases, however, the hyphae appear unpigmented and a specific stain for melanin, the Masson–Fontana stain, must be used to reveal the presence of fungal pigment (truly dematiaceous fungi) and to rule out hyalohyphomycosis 1 .…”

Section: Discussionmentioning

confidence: 99%

Disseminated pheohyphomycosis

Shivaswamy¹,

Pradhan²,

Chandrashekar³

et al. 2007

Int J Dermatology

View full text Add to dashboard Cite

A 40-year-old male agricultural laborer presented to our clinic with asymptomatic swellings on his left hand and left leg of 2 years' duration. A pea-sized swelling was first noticed on the back of the left hand, which was gradual in onset and slowly progressed to its present size. The patient later noticed multiple swellings over his left leg and thigh, with a similar progression. There was no history suggestive of inflammatory changes or discharge from the lesions. There was no previous history of trauma. The patient was an asthmatic and was on long-term oral steroid therapy (10-20 mg/day prednisolone). None of his family members had similar complaints. On physical examination, the patient was febrile. Cutaneous examination showed multiple, circumscribed, lobulated, non-tender, mobile, cystic swellings of various sizes, ranging from less than 2 cm over the left shin to more than 8 cm over the dorsum of the left hand and ankle (Fig. 1a,b). The surface over these swellings was shiny, smooth, and intact. The skin over the swellings was pliable and normal in color. There was no regional lymphadenopathy. The rest of the clinical examination was normal, except for decreased breath sounds over the left mid and lower pulmonary lobes. Routine laboratory tests, including complete blood count and liver and renal function tests, were within normal limits. Random blood glucose was greater than 400 mg%. Histopathologic examination of one of the cysts (from the hand) showed pheohyphomycotic cysts lined by dense fibrous tissue with chronic inflammatory infiltrate admixed with scattered giant cells in the dermis (Fig. 2). No fungal elements were visualized in the hematoxylin and eosin-stained sections. The fungal elements were found within the cystic cavity on special staining with Gomori's methenamine silver (GMS) and Masson-Fontana stains. The hyphae had irregularly placed branches and showed constrictions around their septae, thus resembling pseudohyphae and yeast forms (Fig. 3). Fine needle aspiration cytology from one of the swellings showed the presence of filamentous fungi on KOH examination and brown-pigmented distorted filaments and yeast-like cells on Masson-Fontana staining (Fig. 4a,b). The positive Masson-Fontana stain was indicative of the presence of melanin in the fungal hyphae, even when the fungal hyphae were not pigmented in the hematoxylin and eosin-stained section. Periodic acid-Schiff reagent also stained the fungal elements, thus confirming our diagnosis of pheohyphomycosis and ruling out the possibility of hyalohyphomycosis. The culture for fungus from the swelling aspirate grew contaminants. The chest X-ray showed dense nodular shadows in the left lower and mid pulmonary lobes. Sputum for acid-fast bacilli and Mantoux test were negative. During the hospital stay, the patient developed high fever and showed altered behavior, for which a computed tomography scan of the brain was performed; this showed evidence of multiple ring enhancing lesions in both frontal lobes. Ultrasound of the abdomen was normal. O...

show abstract

“…Surgical excision is the preferred treatment when feasible. Saturated solution of potassium iodide, amphotericin B, griseofulvin, 5-flucytosine, and members of the imidazole group, including ketoconazole and fluconazole, have been reported to be effective in the treatment of phaeohyphomycosis (4,6).…”

Section: Discussionmentioning

confidence: 99%

Hyalohyphomycosis masquerading as squamous cell carcinoma

Griffin

McFarland

1991

J Cutan Pathol

View full text Add to dashboard Cite

A case of primary cutaneous hyalohyphomycosis in a healthy individual is presented. The initial clinical impression was keratoacanthoma or squamous cell carcinoma. Upon excision, the lesion proved to be an example of cutaneous hyalohyphomycosis due to an unidentified, non-pigmented fungal organism. The lesion was completely excised, and the patient was treated with saturated solution of potassium iodide. To date, there has been no evidence of recurrence. The clinical, histologic and mycologic aspects of hyalophyphomycosis are discussed.

show abstract

Primary cutaneous phaeohyphomycosis

Cited by 29 publications

References 11 publications

Pheohyphomycotic cyst

Pheohyphomycotic cyst

Disseminated pheohyphomycosis

Hyalohyphomycosis masquerading as squamous cell carcinoma

Contact Info

Product

Resources

About