Primary cutaneous γδ‐T‐cell lymphoma treated with low‐dose methotrexate and narrowband ultraviolet B irradiation: Report of a case with testicular involvement

Fujii, Mizue; Uehara, Jiro; Honma, Masaru; Ito, Yasuhiro; Takahashi, Hidetoshi; Ishida‐Yamamoto, Akemi; Iizuka, Hajime

doi:10.1111/j.1346-8138.2010.00998.x

Cited by 19 publications

(14 citation statements)

References 20 publications

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“…The authors of a recent large series comprising 53 cases of this lymphoma type challenged the concept of cutaneous γ/δ+ T‐cell lymphoma as a distinct entity and demonstrated its complexity and heterogeneity, highlighting the overlapping features with other lymphoma entities . Observations of cases with indolent behaviour have been reported by others . Paediatric cases of CGD‐TCL are very rare.…”

Section: Resultsmentioning

confidence: 84%

“…108 Observations of cases with indo-lent behaviour have been reported by others. [109][110][111][112][113][114] Paediatric cases of CGD-TCL are very rare. For example, no single paediatric case was included in the series of Guitart et al 108 Some children with CGD-TCL were included in a particular series but it is difficult, if possible at all, to extract conclusive informations.…”

Section: Extranodal Nk/t-cell Lymphoma Nasal-type Hydroa Vacciniformentioning

confidence: 99%

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Paediatric cutaneous lymphomas: a review and comparison with adult counterparts

Kempf

Kazakov

Белоусова

et al. 2015

Acad Dermatol Venereol

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Primary cutaneous lymphomas (CL) in children is rare. Only a few studies focused specifically on paediatric CL and therefore little is known whether primary CL in children are similar to or different from their adult counterparts with respect to the clinicopathological presentation, behaviour and prognosis. An extensive literature search using PubMed/MEDLINE from January 1995 through July 2014 was undertaken for articles reporting cases of paediatric CL. In addition, we identified 31 children with CL in our institutions. Mycosis fungoides and lymphomatoid papulosis are the two most prevalent lymphoma forms in children. A few entities of cutaneous lymphomas such as cutaneous diffuse large B-cell lymphoma leg type, and Sézary syndrome have not been reported so far in children. Other lymphoma entities such as hydroa vacciniforme-like lymphoma are mostly seen in certain geographic areas (Asia, Central and South America). In the paediatric population, low-malignant indolent forms such as primary cutaneous marginal zone lymphoma and primary cutaneous follicle centre lymphoma are very rare, whereas the more aggressive forms of B-cell lymphomas, precursor lymphoblastic lymphomas, and blastic plasmacytoid dendritic cell neoplasm are the most common forms in children, mostly involving the skin secondarily. Most paediatric lymphomas have similar clinicopathological features and course as their adults counterparts, particularly in the group of cutaneous T-cell lymphomas. The spectrum of cutaneous B-cell lymphomas in children significantly differs from the one in adults. Diagnostic work-up and treatment of paediatric patients with lymphomas are best achieved in close collaboration with paediatric haematopathologists and oncologists.

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Section: Resultsmentioning

confidence: 84%

Section: Extranodal Nk/t-cell Lymphoma Nasal-type Hydroa Vacciniformentioning

confidence: 99%

Paediatric cutaneous lymphomas: a review and comparison with adult counterparts

Kempf

Kazakov

Белоусова

et al. 2015

Acad Dermatol Venereol

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“…More studies and observations are warranted to shed light on the correct classifications of such cases to establish whether they represent a variant of MF or a more indolent form of epidermotropic or folliculotropic CGD-TCL for which less aggressive treatment may be effective. 10,26,31,32 …”

Section: Discussionmentioning

confidence: 99%

Two Cases of Primary Cutaneous Lymphoma With a γ/δ+ Phenotype and an Indolent Course

Kempf¹,

Kazakov

Scheidegger

et al. 2014

The American Journal of Dermatopathology

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Cutaneous [gamma]/[delta]+ T-cell lymphoma (CGD-TCL) is a rare but aggressive lymphoma associated with a poor prognosis in most patients. The clinicopathological spectrum is variable including predominantly epidermotropic infiltrates manifesting with patches and plaques or tumors with dermal and/or subcutaneous infiltrates. The diagnosis of CGD-TCL requires the demonstration of a [gamma]/[delta]+ phenotype by immunohistochemistry. We report 2 patients with epidermotropic cutaneous T-cell lymphomas displaying a [gamma]/[delta]+ phenotype, but exhibiting an indolent course. In one patient, the clinical presentation was similar to mycosis fungoides in patch and plaque stage, but recurrent blister formation within the lesions was observed accompanied by fever and arthralgias, whereas the second patient presented with 2 localized erosive plaques on the left temple and dense epidermotropic and dermal diffuse and folliculotropic infiltrates of atypical small-to-medium-sized lymphocytes. exhibiting an indolent course. In one patient, the clinical presentation was similar to mycosis fungoides in patch and plaque stage, but recurrent blister formation within the lesions was observed accompanied by fever and arthralgias, whereas the second patient presented with 2 localized erosive plaques on the left temple and dense epidermotropic and dermal diffuse and folliculotropic infiltrates of atypical small-tomedium-sized lymphocytes. These cases corroborate the view that expression of a g/d+ phenotype in cutaneous T-cell lymphomas per se does not portend a worse prognosis and that CGD-TCL may represent a clinically and prognostically heterogeneous group.

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“…Less commonly used, yet still valid phototherapy options include Broad Band UVB (270–390 nm, BB‐UVB), UVA1 and monochromatic excimer light phototherapy (308 nm). All these treatments have some evidence of efficacy in the treatment of MF, but very limited data of efficacy on other cutaneous lymphoma subtypes …”

Section: General Aspects Of Phototherapymentioning

confidence: 99%

Standardization of regimens in Narrowband UVB and PUVA in early stage mycosis fungoides: position paper from the Italian Task Force for Cutaneous Lymphomas

Grandi

Fava

Rupoli

et al. 2018

Acad Dermatol Venereol

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UV-based (PUVA and narrowband UVB) phototherapy is broadly and commonly used in the treatment of Cutaneous T-cell Lymphomas (CTCL), yet unfortunately, the evidence for the efficacy of these treatments is based only on case series or prospective but non-randomized studies. Therefore, no internationally approved guidelines exist and no standardization of schedules has been proposed. Recently, consensus guidelines have been published by the United States Cutaneous Lymphoma Consortium. The aim of this study was to review the biological and clinical evidences on PUVA and NB-UVB in CTCL and to critically evaluate acceptability and feasibility of these guidelines in the real-life setting from the perspective of the Cutaneous Lymphoma Task Force of the Italian Lymphoma Foundation (Fondazione Italiana Linfomi, FIL).

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Primary cutaneous γδ‐T‐cell lymphoma treated with low‐dose methotrexate and narrowband ultraviolet B irradiation: Report of a case with testicular involvement

Cited by 19 publications

References 20 publications

Paediatric cutaneous lymphomas: a review and comparison with adult counterparts

Paediatric cutaneous lymphomas: a review and comparison with adult counterparts

Two Cases of Primary Cutaneous Lymphoma With a γ/δ+ Phenotype and an Indolent Course

Standardization of regimens in Narrowband UVB and PUVA in early stage mycosis fungoides: position paper from the Italian Task Force for Cutaneous Lymphomas

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