Primary Diffuse Large B Cell Lymphoma Mimicking Hyperplastic Reactive Lesion (Lymphoma of the Oral Cavity)

Donaduzzi, Liziane Cattelan; Reinheimer, Angélica; Silva, Maria Augusta Ramires da; Noronha, Lúcia de; Johann, Aline Cristina Batista Rodrigues; Franco, Ademir; Couto, Soraya de Azambuja Berti; Souza, Paulo Henrique Couto

doi:10.1155/2018/2981689

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…According to the project of the International Agency for Research on Cancer (IARC)-GLOBOCAN, 509,590 new cases of NHL and 248,724 deaths were estimated to occur in 2018, worldwide 9. The incidence rates for NHL are increasing annually and represent the eleventh most frequent type of cancer in Brazil 8. In the oral cavity, lymphoma can appear anywhere in the mouth but predominates on the hard palate, gingiva, and tongue 1.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical features, such as swelling, pain, paresthesia, tooth mobility, or pathologic fracture, are frequent but non-specific, which may lead to misdiagnosis. In the literature, several reports illustrate the challenging diagnosis of oral lymphoma 6 - 8. Here, we present an uncommon case of primary NHL of the mandible, which was initially misdiagnosed as periodontal disease.…”

Section: Introductionmentioning

confidence: 91%

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Primary diffuse large B-cell lymphoma of the mandible

et al. 2019

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Primary intraosseous non-Hodgkin lymphoma in the mandible is uncommon, representing about 0.6% of all extranodal lymphomas. We present the case of a 51-year-old male with a 4-month complaint of mandibular swelling and paresthesia, which had been previously submitted to an unsuccessful periodontal treatment. The intra-oral evaluation showed an extensive swelling with teeth mobility in the right mandible body. The panoramic radiography and computed tomography images showed an extensive osteolytic lesion. An incisional biopsy was performed and the histopathological and immunohistochemical analysis established the diagnosis of diffuse large B-cell lymphoma. The treatment included six cycles of chemotherapy with complete remission. The patient is under the seventh month of follow-up with no evidence of relapse. Although uncommon in the oral cavity, lymphoma should be considered in the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Primary diffuse large B-cell lymphoma of the mandible

et al. 2019

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“…Also, regarding the cellular origin, NHL is generally classified into B lymphocyte (B cell), T lymphocyte (T cell), and natural killer T cell (NKT) types [ 5 ]. The diffuse large B-cell lymphoma (DLBCL) is the most common type, comprising approximately 30% of all lymphomas, while the NK/TL subtype is rare and accounts for almost 2% of all lymphomas [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Intraoral Extranodal Natural Killer Cell/T-Cell Lymphoma of the Hard Palate

Ahmadi-Motamayel,

Najar-Karimi,

Abbasi

et al. 2023

Case Reports in Dentistry

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Natural killer cell/T-cell lymphoma (NK/TL) is a rare subtype of non-Hodgkin’s lymphoma (NHL) associated with the Epstein-Barr virus (EBV) and requires early detection, which can be very challenging. NK/TL often arises in the nasal cavity and can then spread to the oral cavity, but the case presented here is an unusual presentation of NK/TL in a 66-year-old edentulous male patient who initially presented an intraoral exophytic lesion in the palate that appeared within 3 months. We report the present case to highlight the challenges of reaching an accurate diagnosis given the diverse clinical manifestations of NK/TL.

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Linfoma difuso de células B grandes localizado en paladar. Caso clínico //Diffuse B large cells lymphoma located in the palate. Clinical case

González Roma,

Carosi,

Sarquis

et al. 2024

Rev Asoc Odontol Argent

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Objetivo: Presentar un caso clínico de linfoma no Hodgkin (subtipo difuso de células B grandes) asentado en paladar duro y describir sus particularidades clínicas, imagenológicas e histopatológicas. Teniendo presente la baja ocurrencia del linfoma difuso de células B grandes primario en la cavidad bucal, es oportuno enfatizar la importancia del reconocimiento de esta entidad. Asimismo, es de considerar la dificultad que conlleva su diagnóstico debido a su manifestación clínica inespecífica por lo que, frecuentemente, se confunde con otras entidades patológicas como procesos inflamatorios odontogénicos. Caso clínico: Un paciente de 82 años acude a la consulta estomatológica privada derivado por su odontóloga. El paciente refería una lesión indolora en el paladar de dos meses de evolución. El examen estomatológico confirmó la presencia de un tumor ulcerado. El diagnóstico de la entidad fue confirmado por medio de biopsia con estudio anatomopatológico junto a técnicas de inmunomarcación. //Aim: To present a clinical case of a non-Hodgkin lymphoma (diffuse large B subtype) located in the hard palate and describe its clinical, imaging and histopathological features. Considering the rare occurrence of primary diffuse large B cell lymphoma in the oral cavity, it is appropriate to emphasize the importance of identifying this entity. In addition, it is significant to note the difficulty that making a diagnosis entails, due to its non-specific clinical manifestation, which is why it is frequently confused with other pathological entities such as odontogenic inflammatory processes. Case report: An 82-year-old male patient was referred to the private dentistry office referred by his dentist. The patient reported a painless lesion on the palate of two months. The stomatological examination confirmed the presence of an ulcerated tumor. The diagnosis of the entity was confirmed by biopsy with anatomopathological study together with immunostaining techniques.

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Primary Diffuse Large B Cell Lymphoma Mimicking Hyperplastic Reactive Lesion (Lymphoma of the Oral Cavity)

Cited by 3 publications

References 18 publications

Primary diffuse large B-cell lymphoma of the mandible

Primary diffuse large B-cell lymphoma of the mandible

Intraoral Extranodal Natural Killer Cell/T-Cell Lymphoma of the Hard Palate

Linfoma difuso de células B grandes localizado en paladar. Caso clínico //Diffuse B large cells lymphoma located in the palate. Clinical case

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