Primary Diffuse Large B-Cell Lymphoma of the Descending Colon

Sharma, Bashar; Pavelock, Natalie; Antoine, M; Shah, Mili; Galbraith, Kristyn; Rawlins, Sekou

doi:10.1016/j.amjms.2019.05.004

Cited by 11 publications

(8 citation statements)

References 22 publications

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“…As a long-term widely used clinical staging method for NHL, Ann Arbor staging was easily got and accessible, and its predictive efficacy was comparable to that of the Lugano staging in prognostic estimation (23), so it was reasonable to use Ann Arbor staging as a predictor in this study. Patients whose Primary site was the colon have the poorest prognosis, which was the same as the study by Sharma et al (24). When the colon was involved, clinical symptoms appeared later and were more non-specific, these could lead to delayed diagnosis and a poorer prognosis.…”

Section: Discussionsupporting

confidence: 65%

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A visual model for prognostic estimation in patients with primary diffuse large B-cell lymphoma of small intestine and colon: analysis of 1,613 cases from the SEER database

Wang¹,

Song²,

Wen³

et al. 2021

Transl Cancer Res TCR

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Background: Treatment modalities for primary diffuse large B-cell lymphoma of Small intestine and colon (PIC-DLBCL) have changed significantly during the past decades. However, limited information on the trends of clinical outcome of PIC-DLBCL patients has been reported, and the influence of marital status and medical insurance on prognosis is ignored. Methods: This was a retrospective analysis the survival of PIC-DLBCL patients using the Surveillance, Epidemiology, and End Results (SEER) database between 2002 and 2016. The patients were divided into the training and validation cohort. In the training cohort, univariate and multivariable Cox regression analysis, Log-rank test and the Kaplan-Meier method were used to find out the independent prognostic factors, from which the visual prognostic model (nomogram and graphical web page) was established. C-index and calibration plots were used to evaluate the prediction accuracy of the model. In the validation cohort, both Decision curve analysis (DCA) and Receiver operating characteristic (ROC) curve was performed to compare the model with the International Prognostic Index (IPI) scoring model which is universally used to estimate prognosis of PIC-DLBCL.Results: A total of 1,613 patients were collected, and the 5-year overall survival of all cases was 64.5%.

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Section: Discussionsupporting

confidence: 65%

“…Patients whose Primary site was the colon have the poorest prognosis, which was the same as the study by Sharma et al . ( 24 ). When the colon was involved, clinical symptoms appeared later and were more non-specific, these could lead to delayed diagnosis and a poorer prognosis.…”

Section: Discussionmentioning

confidence: 99%

A visual model for prognostic estimation in patients with primary diffuse large B-cell lymphoma of small intestine and colon: analysis of 1,613 cases from the SEER database

Wang¹,

Song²,

Wen³

et al. 2021

Transl Cancer Res TCR

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“…With a total remission rate of 88.2% and a complete remission (CR) rate of 52.9%, Zhou et al used DDGP (gemcitabine, pegaspargase, cisplatin, and dexamethasone) regimen to treat 17 patients with recurrent and refractory extranodal NK/T cell lymphoma [ 19 ]. Besides, the addition of rituximab to CHOP (R-CHOP) has proven to have higher response rates and improve the clinical outcome of patient with DLBL and R-CHOP [ 20 ]. Lee reported that cyclophosphamide, vincristine, and prednisolone (CVP) chemotherapy played a positive impact on MALT treatment [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Esophageal Lymphoma: Clinical Experience in Diagnosis and Treatment

Zhuang

Zheng

et al. 2021

Cureus

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Primary esophageal lymphoma is a rare malignant tumor, which is often misdiagnosed. To improve the diagnosis and treatment of this disease, we presented one case admitted at our institution and a literature review of primary esophageal lymphoma cases, including the clinical data, features of imaging, endoscopy and pathology, treatment, and prognosis. The symptoms were non-specific. Under endoscopy, most of the lesions were located in the middle and lower segment of the esophagus, behaving as ulcers, polyps, or submucosal masses, always accompanying with esophageal stricture. The diagnosis of primary esophageal lymphoma was highly dependent on pathological and immunohistochemical examination, hence stacked sampling was suggested to improve the positive rate of mucosal biopsy. Combination of chemotherapy and radiotherapy may be the first choice of treatment, surgical and endoscopic resections may be an alternative solution as well. The therapeutic effect and prognosis were slightly better than those of other esophageal malignant tumors.

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“…Chang [28] reported that primary colonic lymphoma showed male dominance. Primary colonic lymphoma accounts for 0.2% to 0.6% of all colorectal malignancies [29]. Most colonic lymphomas were reported to be B-cell lymphoma, but T-cell lymphoma has also been reported in Asia [30].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Incidence and Clinical Features of Colorectal Nonadenocarcinoma in Korea: A National Cancer Registry-Based Study

et al. 2020

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Purpose: Although most colorectal malignancies are adenocarcinomas from mucosa, various types of malignant and benign tumors can develop. Due to extremely low incidence, little research has been conducted. The purpose was to assess incidence and compare it according to demographic factors.Methods: Data from the Korea National Cancer Registry from 2007 to 2016 were used. The crude incidence, age-standard incidence rate (ASR) of colorectal nonadenocarcinomas were calculated.Results: Over 11 years, there were 267,142 patients with colorectal malignancies. The patients of 14,495 (5.43%) were diagnosed with nonadenocarcinoma. The ASR was 2.52 per 100,000 in men and 1.56 in women. Lesions were classified according to histologic categories; neuroendocrine tumor (NET) was the most common malignancy (10,919 [75.33%]). Nonadenocarcinoma was the most common in 40s and 50s (40 to 49 years, 3,530 [24.35%]; 50 to 59 years, 3,991 [27.53%]). Lymphoma was high (54.46%) in patients in teenagers. Proportion of NET decreased with age and that of carcinoma increased with age. Carcinoma, sarcoma, and lymphoma were more common among men and melanoma was more common among women. The most common site was the rectum (11,066 [76.34%]). Lymphoma occurred more frequently in proximal colon. Melanoma, gastrointestinal stromal tumor, and NET occurred mostly in rectum. A total of 10,155 patients (70.06%) were classified as having localized disease.Conclusion: This study is meaningful as it is the first study to examine incidence of colorectal nonadenocarcinoma. Differences in incidence of different lesions based on demographic factors were identified. This study will play a role in cancer prevention and diagnosis projects.

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Primary Diffuse Large B-Cell Lymphoma of the Descending Colon

Cited by 11 publications

References 22 publications

A visual model for prognostic estimation in patients with primary diffuse large B-cell lymphoma of small intestine and colon: analysis of 1,613 cases from the SEER database

A visual model for prognostic estimation in patients with primary diffuse large B-cell lymphoma of small intestine and colon: analysis of 1,613 cases from the SEER database

Primary Esophageal Lymphoma: Clinical Experience in Diagnosis and Treatment

Analysis of the Incidence and Clinical Features of Colorectal Nonadenocarcinoma in Korea: A National Cancer Registry-Based Study

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