Primary diffuse leptomeningeal gliomatosis: early diagnostic signs

Šulentić, Vlatko; Hajnšek, Sanja; Gadže, Željka Petelin; Kovač, Andreja Bujan; Nanković, Sibila

doi:10.1007/s10072-015-2225-y

Cited by 3 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Later on hydrocephalus is developed, and diffuse thickening and contrast enhancement of the leptomeninges occurs [ 2 , 14 ]. CSF examination typically shows increased CSF pressure, hyperproteinorrhachia (up to 12.9 g/l in our patient) and lymphocytic pleocytosis with normal or lowered glucose amount can be present [ 15 , 16 ]. Unlike leptomeningeal carcinomatosis and secondary meningeal gliomatosis, cytologic CSF examination is usually not sensitive enough in PDLG [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Primary diffuse leptomeningeal gliomatosis as a rare cause of pain in cervical spine

et al. 2016

View full text Add to dashboard Cite

BackgroundPrimary diffuse leptomeningeal gliomatosis (PDLG) is a very rare neuro-oncological disease, with only 90 cases of PDLG described in medical literature so far.Case presentationWe present a case report of a 56-years-old female patient, who was originally hospitalized due to cervical spine pain lasting several months. Despite complex diagnostics and treatment, the neurological state of the patient progressively deteriorated. Patient died 10 months after the first reported symptom. Postmortem pathological findings resulted in the diagnosis of PDLG.ConclusionsAffection of the cervical spine in early stages of PDLG is rare and has been described in only six patients so far. PDLG is a fatal neuro-oncological disease and it must be kept in mind in the differential diagnosis of persistent back pain syndromes.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary diffuse leptomeningeal gliomatosis as a rare cause of pain in cervical spine

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Typical findings from MRI with gadolinium contrast (Gd) in LMS cases include an abnormal, diffuse leptomeningeal thickening and Gd enhancement at multiple sites, including the spinal cord [ 2 ]. Analysis of the CSF may show a marked increase in protein level, normal or low glucose levels, lymphocytosis, and an elevated pressure.…”

Section: Methodsmentioning

confidence: 99%

“…The most common grade III tumor is anaplastic astrocytoma (AA) and grade IV tumor is glioblastoma multiforme (GBM). There is a lack of consensus on the appropriate treatment for PDLG; most treatment regimens mainly focus on chemoradiotherapy and palliative management [ 1 2 3 ]. PDLG is typically characterized by glial cell infiltration with or without specific evidence of a primary brain or spinal cord mass lesion.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of High-Grade Glioma with Primary Leptomeningeal Seeding at Initial Diagnosis in a Single Center Study

Kwon

Hwang

et al. 2020

Brain Tumor Res Treat

View full text Add to dashboard Cite

Background High-grade glioma (HGG) with primary leptomeningeal seeding (PLS) at initial diagnosis is rare. The purpose of this study was to identify its clinical features and to describe the clinical treatment outcomes. Methods We retrospectively reviewed the medical records of patients with HGG (World Health Organization grade III or IV) at our institution between 2004 and 2019, and patients with PLS at the initial diagnosis were enrolled in the study. Clinical features, such as the location of leptomeningeal seeding, surgical methods, and degree of resection, were sorted based on electronic medical records also containing performance scale, and hematological and serological evaluations. Radiological findings and immunohistochemical categories were confirmed. Furthermore, we sought to determine whether controlling intracranial pressure (ICP) via early cerebrospinal fluid (CSF) diversion increases overall survival (OS) after the initial diagnosis. Results Of the 469 patients with HGG in our institution, less than 2% had PLS at the initial diagnosis. Most patients suffered from headache, diplopia, and dizziness. Pathological findings included 7 glioblastomas and 2 anaplastic astrocytomas. Seven of the 9 patients underwent CSF diversion. All patients were administered concurrent chemoradiotherapy (CCRT) with temozolomide, 89% of which started adjuvant temozolomide and 33% of which completed the six cycles of adjuvant temozolomide. The OS of patients with HGG and PLS was 8.7 months (range, 4-37), an extremely poor result compared to that of other studies. Also, the 1-year and 2-year OS rates were 44.4% and 16.7%, respectively. Conclusion Diagnosis and treatment of HGG with PLS are challenging. Aggressive control of ICP followed by early initiation of standard CCRT seems to be helpful in improving symptoms. However, despite aggressive treatment, the prognosis is poor. A multicenter trial and research may be necessary to create a standardized protocol for this disease.

show abstract

Primary diffuse leptomeningeal oligodendrogliomatosis with an isolated 1p deletion

Gatzert

Durgam

Raghuram

et al. 2019

British Journal of Neurosurgery

View full text Add to dashboard Cite

Primary diffuse leptomeningeal gliomatosis: early diagnostic signs

Cited by 3 publications

References 4 publications

Primary diffuse leptomeningeal gliomatosis as a rare cause of pain in cervical spine

Primary diffuse leptomeningeal gliomatosis as a rare cause of pain in cervical spine

Clinical Characteristics of High-Grade Glioma with Primary Leptomeningeal Seeding at Initial Diagnosis in a Single Center Study

Primary diffuse leptomeningeal oligodendrogliomatosis with an isolated 1p deletion

Contact Info

Product

Resources

About