Primary disorders of oesophageal motility

Stuart, Robert C.; Hennessy, T. P. J.

doi:10.1002/bjs.1800761104

Cited by 22 publications

(9 citation statements)

References 149 publications

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“…In an attempt to induce typical chest pain and correlate this with manometric abnormalities the cholinergic agent edrophonium has been used by many investigators. A negative response however, does not exclude DOS and typical manometric features may be induced without symptoms 17. Consequently its use as a diagnostic test is also limited.…”

Section: Discussionmentioning

confidence: 99%

Diffuse oesophageal spasm: diagnosis by ambulatory 24 hour manometry

Barham

Gotley

Fowler

et al. 1997

Gut

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Background-DiVuse oesophageal spasm (DOS) is a potential cause of intermittent chest pain and/or dysphagia. In the past, the diagnosis of DOS has relied on criteria obtained from standard oesophageal manometry (more than one simultaneous contraction in a series of 10 wet swallows with the rest being peristaltic). As symptoms are intermittent, however, 24 hour manometry may well be more suited to its investigation. Aims-To determine the ability of 24 hour manometry to detect the symptomatic contractions of DOS and to compare standard, laboratory based manometry with 24 hour manometry in its diagnosis. Patients-Three hundred and ninety consecutive patients referred with suspected oesophageal disorders. Methods-Standard laboratory based manometry and 24 hour outpatient manometry. Results-Sixteen patients were classified by 24 hour manometry as having DOS on the basis of painful contractions (spasms) of excessive duration and increased amplitude. Laboratory based manometry failed to detect the majority of these patients with DOS (14/16), and 53/55 were incorrectly labelled as having DOS on the basis of asymptomatic manometric findings. Conclusion-The detection of symptomatic DOS requires 24 hour manometry. (Gut 1997; 41: 151-155)

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Section: Discussionmentioning

confidence: 99%

Diffuse oesophageal spasm: diagnosis by ambulatory 24 hour manometry

Barham

Gotley

Fowler

et al. 1997

Gut

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“…1,2 Manometric features of AC are aperistalsis in esophageal body characterized by either simultaneous or no contractions, and incomplete relaxation of LES. 3,4 Achalasia cardia is further classified into classic (average esophageal body amplitude ≤40 mmHg) and vigorous (average esophageal body amplitude >40 mmHg) types. 5,6 DES is characterized by the following: (1) >10% of esophageal body contractions in response to wet swallows are simultaneous type, (2) mean simultaneous contraction amplitude >30 mmHg, and (3) spontaneous, repetitive and multiple peaked contractions.…”

Section: Introductionmentioning

confidence: 99%

Manometric and symptomatic spectrum of motor dysphagia in a tertiary referral center in northern India

Misra

Chourasia

Ghoshal

2010

Indian J Gastroenterol

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“…Nutcracker esophagus 6 is defined as the presence of high amplitude peristaltic waves in the distal esophagus in patients with symptoms of chest pain and/or dysphagia. The presence of normal peristalsis separates this disorder from classical diffuse esophageal spasm.…”

Section: Introductionmentioning

confidence: 99%

Effect of physical exercise on esophageal motility in patients with esophageal disease

Ravi

Stuart

Byrne

et al. 2005

Diseases of the Esophagus

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The most common type of esophageal dysfunction associated with chest pain is gastroesophageal reflux, which may be induced by exercise. The effect of exercise on esophageal function has mainly been investigated in normal subjects or trained athletes. Few studies have investigated exercise and esophageal motility disorders. One hundred and thirty-five patients underwent ambulatory esophageal manometry and pH monitoring, before, during and immediately after moderate exercise. Patients were divided into four groups: Normal, nutcracker, diffuse spasm and gastroesophageal reflux disease (GERD). Ambulatory manometry and pH were monitored while exercising on a treadmill during which standardized boluses of water were administered. Nutcracker and diffuse spasm patients demonstrated a significant fall in esophageal wave amplitude during exercise compared to controls, which returned rapidly to pre exercise values after resting. There was no evidence of acid reflux in the non-reflux groups during exercise. Reflux was noted in 13 patients with GERD during exercise, none of whom had evidence of reflux at the onset of exercise. When these patients were classified by reflux type, the majority, 11 patients, were found to come from the combined or supine reflux group. Esophageal amplitude in nutcracker esophagus does not increase during moderate exercise. Moderate exercise provokes reflux in GERD patients with combined or supine reflux.

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Primary disorders of oesophageal motility

Cited by 22 publications

References 149 publications

Diffuse oesophageal spasm: diagnosis by ambulatory 24 hour manometry

Diffuse oesophageal spasm: diagnosis by ambulatory 24 hour manometry

Manometric and symptomatic spectrum of motor dysphagia in a tertiary referral center in northern India

Effect of physical exercise on esophageal motility in patients with esophageal disease

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