Primary Disseminated Herpes Simplex of the Newborn

Wheeler, Clayton E.

doi:10.1001/jama.1965.03080060029005

Cited by 66 publications

(12 citation statements)

References 8 publications

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“…Pathological and virological studies of tissues from infants that have died of herpesvirus infections have established that the organs most commonly involved were the brain, lungs, liver, spleen, kidneys, and adrenal glands (2,8,30,31). After intranasal inoculation of newborn mice with HVH type 2, virus initially replicated in cells of the respiratory tract.…”

Section: Discussionmentioning

confidence: 99%

Herpesvirus hominis Infection in Newborn Mice: Treatment with Interferon Inducer Polyinosinic-Polycytidylic Acid

Kern

Overall²,

Glasgow³

1975

Antimicrob Agents Chemother

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Intranasal inoculation of newborn mice with Herpesvirus hominis (HVH) type 2 provides a model for disseminated herpesvirus infections of human newborn infants. Treatment of this experimental infection with polyinosinic-polycytidylic acid [poly(I:C)] significantly increased the mean survival time and markedly altered the pathogenesis of the infection. No significant protection against final mortality was observed. Poly(I:C) therapy completely inhibited detectable viral replication in all target organs tested except the brain. In the brain there was a 2-day delay in the onset of viral replication in treated animals, which correlated with the 1- to 2-day increase in mean survival time. In general, the control of HVH replication occurred in those target organs in which poly(I:C)-induced interferon was detectable. The failure of poly(I:C) to alter the final mortality of newborn mice infected with HVH appears to be primarily due to the lack of sufficient levels of interferon induced in brain tissue and the failure to prevent viral replication in this critical target organ.

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Section: Discussionmentioning

confidence: 99%

Herpesvirus hominis Infection in Newborn Mice: Treatment with Interferon Inducer Polyinosinic-Polycytidylic Acid

Kern

Overall²,

Glasgow³

1975

Antimicrob Agents Chemother

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“…Wheeler and Huffines 3 primary disseminated herpes simplex manifested by vesicular stomatitis in a newborn infant whose mother had primary herpes simplex vulvovaginitis at the time of delivery. Bell and Williams 4 described a case of primary visceral herpes simplex without cutaneous or mucosal lesions in an infant four IRWIN I.…”

Section: Herpe• In Young Infant and Young Adult•mentioning

confidence: 99%

Viral and Viral-Like Diseases of the Mouth

Ship

1965

Postgraduate Medicine

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“…The primary infection occurs usually between 1 and 5 years of age after maternal antibodies have disappeared.1 Although estimated to produce clinical disease only 1% to 10% of the time,1 the primary disease has a spectrum of symptoms ranging from minimal sore throat to high fever, toxicity, pronounced discomfort, and even death from disseminated disease in neonates. 2,3 Acute herpetic gingivostomatitis, the most common form of the primary disease, is characterized by swollen gingiva, with red, bleeding edges. Multiple vesicles may form anywhere within the mouth and soon collapses, resulting in multiple small ulcers with red edges.…”

Section: Report Of a Casementioning

confidence: 99%