Primary dura-based synovial sarcoma of the parafalcine region of brain

Sharma, Shivani; Sharma, Anurag; Lobo, Geover Joslen; Nayak, Madhukar; Pradhan, Dinesh; Samriti,; Bindal, Swati; Gogoi, Kamakhya; Katara, Rahul; Kini, Lata; Mohanty, Sambit K.

doi:10.1016/j.prp.2017.03.005

Cited by 11 publications

(9 citation statements)

References 11 publications

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“…of synovial sarcomas have the same pattern as hemangiopericytomas. [1] Like peripheral nerve sheath tumors, 30% of monophasic and poorly differentiated synovial sarcomas show nuclear and cytoplasmic S-100-positive immunoreaction. [15] The immune reaction to EMA and cytokeratin is negative in malign peripheral nerve sheath tumors; thus, these tests may be used in differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Rare Occurrence of Synovial Sarcoma Originating from Dura Mater

Akdeniz¹

2019

TJ Oncol

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Primary or metastatic dura mater sarcomas are rarely seen, and dural synovial sarcomas are quite rare.Here we report the case of a 60-year-old man who presented with headache, nausea, and vomiting and was found to have a 63×33×40-mm mass with solid and cystic components in parieto-occipital lobe. The mass was resected completely, with no residue detected on postoperative magnetic resonance imagining. On pathological evaluation, a vimentin-, S100-, transducer-like enhancer of split 1-, BCL-2-, and EMApositive and desmin-, PR-, CD99-, PANCK-, and GFAP-negative synovial sarcoma with Ki-67 proliferation index of 12% was detected. Postoperatively, chemotherapy has been started, and it will be followed by radiotherapy. Primary meningeal-derived sarcomas are rare, and differential diagnosis with other meningeal mesenchymal tumors is based on the findings of morphological and immunohistochemical analyses.

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Section: Discussionmentioning

confidence: 99%

“…Primary and metastatic dura mater tumors are rarely seen, and dural synovial sarcomas are quite rare. [1] There have been few reports on dura mater-originated synovial sarcoma; here we report the case of a patient with primary dural synovial sarcoma.…”

Section: Introductionmentioning

confidence: 87%

Rare Occurrence of Synovial Sarcoma Originating from Dura Mater

Akdeniz¹

2019

TJ Oncol

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“…To the best of our knowledge, till date, 27 patients have been reported to have PrISS in English literature. [2,3,5,6,8,9,[11][12][13]17,18] Average age of patients reported till date is 34.9 years. ere was no sex predilection.…”

Section: Review Of the Literature [Table 1]mentioning

confidence: 99%

Primary intracranial synovial sarcoma: A case report and review of literature

Vora

Lath

Swain

et al. 2022

Surgical Neurology International

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Background: Primary intracranial synovial sarcomas (PrISS) are unusual dural based mesenchymal tumors seen most commonly in the supratentorial compartment. They can mimic a spontaneous intracranial hemorrhage or a high-grade glioma on imaging. Case Description: A 31-year-old male presented with headache and right hemiparesis for 2 weeks. CT brain revealed a left frontal spontaneous intracerebral hemorrhage. PrISS revealed a heterogeneously ring enhancing solid cystic lesion with attachment to convexity dura. Intraoperatively, it mimicked a high-grade glioma. Histopathology report showed features of a synovial sarcoma, which was later confirmed with IHC. Classical SYT-SSX2 translocation was confirmed only on RTPCR after fluorescent in situ hybridization (FISH) was negative for same. Whole body positron emission tomography (PET-CT) did not show any extracranial tumor. Despite radiotherapy, there were recurrence and tumor progression at 6 months and the patient succumbed 11 months later. Conclusion: PrISS is an unusual aggressive intracranial neoplasm that carries a worse prognosis when compared nonintracranial synovial sarcomas. Molecular cytogenetics (FISH and RTPCR) are essential for confirming the diagnosis, though FISH seems to have a lower sensitivity and can yield false negative results as was noted in this case.

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“…Synovial sarcoma is a malignant neoplasm of uncertain differentiation, which occurs most frequently in the soft tissues of lower extremities. However, this neoplasm also exhibits a wide anatomic distribution including head and neck, mediastinum, lung, pleura, abdominal wall, gastrointestinal tract, kidney, and intracranial region 1,2 . Although there have been few reports of synovial sarcoma metastasizing to the skin, the occurrence of a primary cutaneous synovial sarcoma is extremely rare, with only six cases reported in the literature 1,3‐6 .…”

Section: Introductionmentioning

confidence: 99%

“…However, this neoplasm also exhibits a wide anatomic distribution including head and neck, mediastinum, lung, pleura, abdominal wall, gastrointestinal tract, kidney, and intracranial region. 1,2 Although there have been few reports of synovial sarcoma metastasizing to the skin, the occurrence of a primary cutaneous synovial sarcoma is extremely rare, with only six cases reported in the literature. 1,[3][4][5][6] Herein, we report a case of monophasic primary cutaneous synovial sarcoma.…”

Section: Introductionmentioning

confidence: 99%

Primary cutaneous synovial sarcoma—Sometimes the hoof beats are zebras

Sharma

Billings

2020

J Cutan Pathol

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Synovial sarcoma accounts for 5% to 10% of soft tissue sarcoma and it typically presents as a deep soft tissue mass. Primary cutaneous presentation is exceptionally rare, with only isolated case reports. We report a case of primary cutaneous synovial sarcoma in a 58‐year‐old woman that presented as a nodule involving the left occipital scalp. A complete radiologic evaluation of the patient failed to reveal any other mass lesion. Histologic sections showed a densely cellular, diffuse spindle cell proliferation within the subcutis. The lesion was composed of uniform, plump spindled cells with nuclei and vesicular chromatin, arranged in haphazard fascicles. There was admixed hemorrhage and a hemangiopericytoma‐like vasculature. Immunohistochemically, the spindled cells showed focal strong positivity for cytokeratin (CK) OSCAR, CK5/6, CK34BE12, and pan‐CK. Fluorescence in situ hybridization was positive for a rearrangement of SYT (SS18), confirming the diagnosis of monophasic synovial sarcoma. Synovial sarcoma should be considered in the differential diagnosis of monomorphous spindle cell tumors, especially if the tumors have a hemangiopericytoma‐like vasculature or express keratins. In such cases, confirmatory molecular testing should be performed to confirm the diagnosis.

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Primary dura-based synovial sarcoma of the parafalcine region of brain

Cited by 11 publications

References 11 publications

Rare Occurrence of Synovial Sarcoma Originating from Dura Mater

Rare Occurrence of Synovial Sarcoma Originating from Dura Mater

Primary intracranial synovial sarcoma: A case report and review of literature

Primary cutaneous synovial sarcoma—Sometimes the hoof beats are zebras

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