Primary dysmenorrhea in adolescents: Association with attention deficit hyperactivity disorder and psychological symptoms

Kabukçu, Cihan; Başay, Bürge Kabukçu; Başay, Ömer

doi:10.1016/j.tjog.2021.01.033

Cited by 22 publications

(25 citation statements)

References 30 publications

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“…However, the previous studies examining the association between dysmenorrhea and mental disorders showed inconsistent findings. Kabukçu et al [35], Westling et al [36], Zhao et al [37], and Gagua et al [38] have reported that dysmenorrhea severity is associated with a higher incidence of depression, anxiety, and stress disorders. Conversely, László et al [39] showed no significant correlations between dysmenorrhea and higher incidence of psychological disorders, whereas Namvar et al [40] reported that women with no dysmenorrhea exhibited higher anxiety symptoms than women with dysmenorrhea, and higher depression scores among women with dysmenorrhea than those without dysmenorrhea were reported.…”

Section: Discussionmentioning

confidence: 99%

COVID-19-Associated Mental Health Impact on Menstrual Function Aspects: Dysmenorrhea and Premenstrual Syndrome, and Genitourinary Tract Health: A Cross Sectional Study among Jordanian Medical Students

Aolymat

Khasawneh

Al‐Akchar

2022

IJERPH

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The physiology of reproduction is affected by psychological distress through neuroendocrine pathways. Historically, COVID-19 is one of the most stressful events with devastating consequences. This research aims to investigate the relationship between dysmenorrhea, PMS, and reproductive tract health on one hand, and COVID-19-related anxiety, depression, and stress on the other among medical students in Jordan. Medical students were invited through teaching platforms and social media to complete an online survey. SPSS software was used to analyze data. A total of 385 medical students participated in this research. Hence, 49.9% of the study population reported severe dysmenorrhea during COVID-19 compared to 36.9% before COVID-19 (p = 0.000). Dysmenorrhea was significantly associated with disruptions of sport and daily activities during COVID-19 (p = 0.015 and p = 0.002, respectively). The prevalence of PMS components, e.g., mastalgia, fatigue, headache, palpitation, and emotional and sleep disturbances, was raised during COVID-19 compared with before (p < 0.05). Symptoms of genitourinary tract infections, such as lower abdominal pain, vaginal discharge, genitalia rash/ulcers and itching, and urgency, were significantly increased after COVID-19 (p < 0.05). Positive Pearson correlations between COVID-19-associated mental health disorders and dysmenorrhea severity, PMS, and genital tract health abnormalities were observed (p < 0.05). The multiple linear regression model revealed that dysmenorrhea severity, PMS symptoms like palpitation, and genitourinary symptoms like lower abdominal pain and urgency were associated with worsening of depression, while dysuria was associated with a protective effect against depression. Moreover, it was observed that dysmenorrhea severity, PMS symptoms, such as headache and palpitation, and urinary urgency were associated with aggravation of anxiety. However, food craving and dysuria were protective against anxiety. Finally, dysmenorrhea severity, PMS symptoms of headache and palpitation, lower abdominal pain, and urgency were related to worsening of stress, whereas the premenstrual symptom of breast pain was a protective factor against stress. This work showed that COVID-19 pandemic-related psychological distress and menstrual, premenstrual, and genitourinary symptoms are closely related. Further future work is required to evaluate the long lasting-effects of the pandemic on mental health and the physiology of reproduction.

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Section: Discussionmentioning

confidence: 99%

COVID-19-Associated Mental Health Impact on Menstrual Function Aspects: Dysmenorrhea and Premenstrual Syndrome, and Genitourinary Tract Health: A Cross Sectional Study among Jordanian Medical Students

Aolymat

Khasawneh

Al‐Akchar

2022

IJERPH

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“…It is known that there is a close association between pain and depression (24). Since the first publication (25) reporting the relationship between dysmenorrhea and depressive symptoms, by Bloom et al in 1978, there is mounting evidence indicates that dysmenorrhea patients are at high risk of depression (7,(10)(11)(12)(13)(14). However, we should also note that several studies (13,14) failed to find a positive association between dysmenorrhea and depressive disorder.…”

Section: Discussionmentioning

confidence: 99%

“…And surprisingly, dysmenorrhea has received slight scientific and clinical attention. Based on relevant studies investigating the different impacts on life in women with or without dysmenorrhea, women with dysmenorrhea are vulnerable to have higher levels of depression, anxiety, somatization, negative self-perception, and hostility ( 7 ). Besides, these women are also prone to reduce productivity, creativity, and job performance ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…A study reported by Liu et al ( 13 ) indicated that subjects with primary dysmenorrhea were susceptible to depression when compared to those without dysmenorrhea (Self-rating distress scale: 34.36 ± 1.95 vs. 28.8 ± 1.58). In addition, Ambresin et al ( 7 ) demonstrated that adolescent girls with severe dysmenorrhea had a 1.87-fold increased risk of depression as compared with those with no/mild/moderate dysmenorrhea. However, some studies failed to support such an association.…”

Section: Introductionmentioning

confidence: 99%

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Significant Increase in Depression in Women With Primary Dysmenorrhea: A Systematic Review and Cumulative Analysis

Zhao

Wu²,

Kang

et al. 2021

Front. Psychiatry

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Women with primary dysmenorrhea are vulnerable to develop a depressive disorder, which is a common form of psycho-disturbance. However, clinical findings are inconsistent across studies, and the evidence has not been previously synthesized. This study aims to investigate whether primary dysmenorrhea is associated with a higher risk of depression via a cumulative analysis. Four electronic databases were systematically searched for the eligible studies. The combined effect was assessed by analyzing the relative risk (RR) and standard mean differences (SMD) with a 95% confidence interval (CI). This cumulative analysis was registered on the PROSPERO (ID: CRD42020169601). Of 972 publications, a total of 10 studies involving 4,691 participants were included. Pooled results from six included studies showed that primary dysmenorrhea was associated with a significant depressive disorder (RR = 1.72, 95%CI: 1.44 to 2.0, P < 0.001; heterogeneity: I2 = 0%, P = 0.544). In addition, synthesis results from two studies provided the BDI scores suggested that dysmenorrhea had significantly higher scores when compared to non-dysmenorrhea (SMD = 0.47, 95% CI: 0.31–0.62, P < 0.001; heterogeneity: I2 = 0%, P = 0.518). However, in the two studies providing the PROMIS T-Score, the pooled result showed that there was no significant difference between women with dysmenorrhea and those without dysmenorrhea (P = 0.466). The overall quality of the evidence in our study was judged to MODERATE. The present study has confirmed the positive relationship between primary dysmenorrhea and depression. Social supports and medical help from pain management physicians or psychologists are important interventions for women with dysmenorrhea-suffering depressive disorder.

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“…2,3 Kabukcu et al reported that PD may be associated with psychiatric distress. 4 However, the effects of long-term menstrual pain on psychological disorder-related neural activity in PD patients remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Machine Learning Analysis Reveals Abnormal Static and Dynamic Low-Frequency Oscillations Indicative of Long-Term Menstrual Pain in Primary Dysmenorrhea Patients

Gui¹,

Chen²,

Zhong³

et al. 2021

JPR

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Background: Previous neuroimaging studies demonstrated that patients with primary dysmenorrhea (PD) exhibited dysfunctional resting-state brain activity. However, alterations of dynamic brain activity in PD patients have not been fully characterized. Purpose: Our study aimed to assess the effect of long-term menstrual pain on changes in static and dynamic neural activity in PD patients. Material and Methods: Twenty-eight PD patients and 28 healthy controls (HCs) underwent resting-state magnetic resonance imaging scans. The amplitude of low-frequency fluctuations (ALFF) and dynamic ALFF was used as classification features in a machine learning approach involving a support vector machine (SVM) classifier. Results: Compared with the HC group, PD patients showed significantly increased ALFF values in the right cerebellum_crus2, right rectus, left supplementary motor area, right superior frontal gyrus, right supplementary motor area, and left superior frontal medial gyrus. Additionally, PD patients showed significantly decreased ALFF values in the right middle temporal gyrus and left thalamus. PD patients also showed significantly increased dALFF values in the right fusiform, Vermis_10, right middle temporal gyrus, right putamen, right insula, left thalamus, right precentral gyrus, and right postcentral gyrus. Based on ALFF and dALFF values, the SVM classifier achieved respective overall accuracies of 96.36% and 85.45% and respective areas under the curve of 1.0 and 0.95. Conclusion: PD patients demonstrated abnormal static and dynamic brain activities that involved the default mode network, sensorimotor network, and pain-related subcortical nuclei. Moreover, ALFF and dALFF may offer sensitive biomarkers for distinguishing patients with PD from HCs.

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Primary dysmenorrhea in adolescents: Association with attention deficit hyperactivity disorder and psychological symptoms

Cited by 22 publications

References 30 publications

COVID-19-Associated Mental Health Impact on Menstrual Function Aspects: Dysmenorrhea and Premenstrual Syndrome, and Genitourinary Tract Health: A Cross Sectional Study among Jordanian Medical Students

COVID-19-Associated Mental Health Impact on Menstrual Function Aspects: Dysmenorrhea and Premenstrual Syndrome, and Genitourinary Tract Health: A Cross Sectional Study among Jordanian Medical Students

Significant Increase in Depression in Women With Primary Dysmenorrhea: A Systematic Review and Cumulative Analysis

Machine Learning Analysis Reveals Abnormal Static and Dynamic Low-Frequency Oscillations Indicative of Long-Term Menstrual Pain in Primary Dysmenorrhea Patients

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