Primary ectopic thyroid papillary carcinoma in the floor of the mouth and tongue: a case report

Tu, Hsi Feng; Chang, Richard Che-Shoa; Yang, An Hang; Chang, Kee-Hyun

doi:10.1054/bjom.2001.0686

Cited by 24 publications

(9 citation statements)

References 8 publications

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“…2,5,29,30 Of the patients treated with external beam radiation, all 3 had recurrence of their disease or no response to treatment. [26][27][28] Two passed away secondary to their disease, 26,27 and 1 required subsequent RAI for cure. 28 In the transoral group, persistent disease requiring additional surgery was found in the neck or at the primary site in 3 of 7 cases.…”

Section: Literature Reviewmentioning

confidence: 99%

“…[26][27][28] Two passed away secondary to their disease, 26,27 and 1 required subsequent RAI for cure. 28 In the transoral group, persistent disease requiring additional surgery was found in the neck or at the primary site in 3 of 7 cases. 1,18,24 No reports of persistent disease requiring additional surgery or treatment were noted in the 8 transcervical/trans-hyoid approaches, 3,7,10,11,13,21,25 the Trotter procedure, 9 and the 2 lateral pharyngotomies.…”

Section: Literature Reviewmentioning

confidence: 99%

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Lingual Thyroid Carcinoma: A Case Report and Review of Surgical Approaches in the Literature

Stokes

Interval

Patel

2018

Ann Otol Rhinol Laryngol

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Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Lingual Thyroid Carcinoma: A Case Report and Review of Surgical Approaches in the Literature

Stokes

Interval

Patel

2018

Ann Otol Rhinol Laryngol

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“…Although generally limited, the thyroxine‐producing capacity of patients with ectopic thyroid remains constant, suggesting normal post‐natal survival of ectopic cells (29, 30). Further evidence that thyroid cells that have failed to complete their migration can be fully functional is that cancer (31) and hyperthyroidism (32) have been reported to arise from ectopic thyroid tissue.…”

Section: Normal and Abnormal Thyroid Gland Developmentmentioning

confidence: 99%

Development of the thyroid gland: lessons from congenitally hypothyroid mice and men

Vliet

2003

Clinical Genetics

117

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Congenital hypothyroidism is the most common congenital endocrine disorder (one newborn in 3000) and represents the most common cause of preventable mental retardation. In 10-20% of cases, it is due to autosomal recessive functional disorders leading to goiter formation (thyroid dyshormonogenesis). In the remainder, it is due to thyroid dysgenesis, which comprises usually isolated defects in: (1) migration of the median thyroid anlage, leading to a round cluster of ectopic cells (usually in a sublingual position) with no other thyroid tissue present; (2) differentiation or survival of the thyroid follicular cells leading to athyreosis; and (3) growth of a thyroid with the normal bilobed shape and in the normal cervical position (orthotopic hypoplasia). Mouse knock-outs have demonstrated that thyroid transcription factor-1 (TTF-1) and PAX8 are required for the survival and proliferation of thyroid follicular cell precursors, TTF-2 for their downward migration and the thyrotropin receptor (TSHR) for post-natal thyroid growth. In humans, thyroid dysgenesis is generally a sporadic malformation but an affected relative is found in 2% of cases, a figure 15-fold higher than by chance alone. Pedigree analysis is most compatible with dominant inheritance with variable penetrance. However, mutations in TTF-1, TTF-2, PAX8 and TSHR are found in <10% of patients with congenital hypothyroidism and these predominantly have orthotopic thyroid hypoplasia, often associated with other malformations. This low yield and the discordance of >90% of monozygotic twin pairs suggests that isolated thyroid ectopy or athyreosis most often results from early somatic mutations, epigenetic modifications or stochastic developmental events.

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“…High cellular atypia, solid growth, and nuclear atypia may be other histologic findings that help substantiate the diagnosis but should not be used as the only findings to diagnose malignant transformation 3 . Kao 15 reports using thyroglobulin immunostaining, which has been reported to have 100% specificity and greater than 95% sensitivity for the diagnosis of lingual thyroid carcinoma 5 . However, immunohistochemistry is only necessary if the diagnosis is in question because papillary and follicular carcinomas have readily identifiable histopathologic characteristics.…”

Section: Discussionmentioning

confidence: 99%

Lingual Thyroid Carcinoma With Nodal Metastasis

Kennedy

Riefkohl

2007

The Laryngoscope

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A case of lingual papillary thyroid carcinoma with cervical metastasis is reported. Treatment is best managed with surgical excision of all thyroid tissue followed by radioactive iodine ablation. Surgical approaches to the tongue base need to be considered based on the size of the lingual primary tumor and the need to address lymph node metastases gland. This is the first reported case in the literature of lingual papillary thyroid carcinoma presenting with cervical nodal metastasis in a female with absence of an orthotopic thyroid gland. This is also the first report to show that papillary and not follicular cell carcinoma is the predominating histopathology in lingual thyroid carcinoma.

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Primary ectopic thyroid papillary carcinoma in the floor of the mouth and tongue: a case report

Cited by 24 publications

References 8 publications

Lingual Thyroid Carcinoma: A Case Report and Review of Surgical Approaches in the Literature

Lingual Thyroid Carcinoma: A Case Report and Review of Surgical Approaches in the Literature

Development of the thyroid gland: lessons from congenitally hypothyroid mice and men

Lingual Thyroid Carcinoma With Nodal Metastasis

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