Primary effusion lymphoma in a patient with a good outcome on steroid alone treatment

Koren, Ofir; Aviv, Ariel; Kelbert, Moran Avraham; Rozner, Ehud; Lihtman, Liza; Halfin, Elya; Turgeman, Yoav

doi:10.1002/ccr3.4020

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…Guler and colleagues have reported non-response to the CHOP regimen in the EBV-positive solid variant of PEL [18]. On the other hand, PEL with complete remission on a tapering dose of steroid therapy alone is also reported in an 84year-old HIV-negative patient with PEL [19]. The prognosis is generally poor, with an average survival time of less than 24 months, despite treatment with both antiretrovirals and chemotherapy [20].…”

Section: Discussionmentioning

confidence: 99%

Primary Effusion Lymphoma Secondary to Human Herpesvirus 8 (HHV-8) Infection in an Immunocompetent Host: A Case Report

Pandey,

Tan,

Tun

et al. 2024

Cureus

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Primary effusion lymphoma (PEL) is a rare, aggressive, mature type of B-cell lymphoma that usually causes malignant, lymphomatous effusions in the absence of a solid mass. This is commonly seen in immunosuppressed individuals such as those with underlying malignancies, human immunodeficiency virus infection (HIV), cirrhosis, and a history of solid organ transplantation who are infected with human herpesvirus 8 (HHV-8). Clinical presentation varies depending on the extent of disease like shortness of breath, abdominal distention, and typical B symptoms like weight loss, fever, and night sweats. Morphological and immunohistochemical analysis of pleural fluid is required for diagnosis of PEL. Recent case studies are increasingly being reported with cases of PEL presenting in immunocompetent individuals infected with HHV-8. We present a case of PEL in an immunocompetent host and highlight its presentation, diagnosis, and management approaches. Due to the well-known association of PEL with immunocompromised status, the diagnosis is often overlooked in immunocompetent individuals. This case would further highlight the increasing association and the need for clinical vigilance in diagnosing PEL in immunocompetent patients.

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Section: Discussionmentioning

confidence: 99%

Primary Effusion Lymphoma Secondary to Human Herpesvirus 8 (HHV-8) Infection in an Immunocompetent Host: A Case Report

Pandey,

Tan,

Tun

et al. 2024

Cureus

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“…2,3 However, primary effusion lymphoma may also occur in immunocompetent patients infected with either human herpes virus type 8 or Epstein-Barr virus. 4 This condition presents with fluid accumulation in body cavities, resulting in constitutional symptoms such as fever, weight loss, and manifestations related to external pressure, such as difficulty breathing or abdominal pain. 1,4 The diagnosis of PEL presents challenges and requires a multidisciplinary approach involving radiology, pathology, clinical presentation, and epidemiology.…”

Section: Introductionmentioning

confidence: 99%

“…4 This condition presents with fluid accumulation in body cavities, resulting in constitutional symptoms such as fever, weight loss, and manifestations related to external pressure, such as difficulty breathing or abdominal pain. 1,4 The diagnosis of PEL presents challenges and requires a multidisciplinary approach involving radiology, pathology, clinical presentation, and epidemiology. Radiologists are essential in verifying the existence of fluid accumulations within body cavities and excluding lymph node enlargement, organ swelling, or any other masses beyond the body cavities to confirm the diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Rare Case of Primary Effusion Lymphoma mimicking Pulmonary Tuberculosis

Idris,

Gubali

2024

Jambura Med. and Health Sci J

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Primary effusion lymphoma (PEL) is a rare large B-cell non-Hodgkin lymphoma (NHL) that usually occurs in immunosuppressed individuals in advanced stages of the disease, presenting as body cavity effusions without detectable tumor mass. We report a 61-years old man presented to the emergency room complaining of effort-related dyspnoea, low-grade fever, night sweats, and a dry cough for several days. He was then put on empirical anti-tubercular treatment (ATT) suspecting Pulmonary Tuberculosis. General examination revealed a decrease oxygen saturation, tachypnea, a bulging tenderness lymph node on the neck. Chest computerized tomography (CT) scan indicated pericardial and pleural effusion with mediastinal dilatation suspected thymoma or lymphoma. A Cardiocentesis needle aspiration was performed; however, the histological pattern was not specific. The patient underwent a surgical biopsy of a left supra-clavicular lymph node. A Classical Hodgkin lymphoma nodular sclerosis type was found in the histopathology examination. Immunohistochemistry detected the tumour cellular markers (i.e., CD30). Chemotherapy treatment for 6 cycles resulted an excellent outcome. In conclusion, radiologists play a vital role in the diagnosis of PEL, detecting effusions in body cavities and excluding the existence of solitary masses or pleural nodules or masses, ultimately narrowing down the differential diagnoses.

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Primary effusion lymphoma in a patient with a good outcome on steroid alone treatment

Cited by 2 publications

References 9 publications

Primary Effusion Lymphoma Secondary to Human Herpesvirus 8 (HHV-8) Infection in an Immunocompetent Host: A Case Report

Primary Effusion Lymphoma Secondary to Human Herpesvirus 8 (HHV-8) Infection in an Immunocompetent Host: A Case Report

Rare Case of Primary Effusion Lymphoma mimicking Pulmonary Tuberculosis

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