Primary endocrine tumours of the liver

Maire, Frédérique; Couvelard, Anne; Vullierme, Marie‐Pierre; Kianmanesh, Réza; O’Toole, Dermot; Hammel, Pascal; Belghiti, Jacques; Ruszniewski, Philippe

doi:10.1002/bjs.5073

Cited by 14 publications

(10 citation statements)

References 32 publications

(53 reference statements)

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“…In a 19‐case series the primary tumor was located 25 and 46 months after LTx in two cases and remained undetermined in another (16). A possible explanation for the difficulty in determining primary location is that the liver tumor itself is the primary (28,29). However, this seems unlikely not only because primary hepatic endocrine tumors are extremely rare (29,30) but also because the multi‐nodular appearance of the lesions in our series is inconsistent with the usual appearance of primary hepatic endocrine tumors that are typically solitary and centrally located (28).…”

Section: Discussionmentioning

confidence: 99%

Predictors of Long-Term Survival After Liver Transplantation for Metastatic Endocrine Tumors: An 85-Case French Multicentric Report

Treut

Grégoire

Belghiti

et al. 2008

American Journal of Transplantation

167

138

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Section: Discussionmentioning

confidence: 99%

Predictors of Long-Term Survival After Liver Transplantation for Metastatic Endocrine Tumors: An 85-Case French Multicentric Report

Treut

Grégoire

Belghiti

et al. 2008

American Journal of Transplantation

167

138

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“…In a study of 393 digestive neuroendocrine tumors, only 5% had a primary neuroendocrine neoplasm in liver[19]. In a study of 13715 neuroendocrine tumors, liver was the second most common site of metastasis after lymph nodes[5].…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine neoplasms of liver - A 5-year retrospective clinico-pathological study applying World Health Organization 2010 classification

Burad¹,

Kodiatte²,

Rajeeb³

et al. 2016

WJG

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AIMTo study the clinicopathological characteristics of neuroendocrine neoplasms (NEN) on liver samples and apply World Health Organization (WHO) 2010 grading of gastroenteropancreatic (GEP) NEN.METHODSClinicopathological features of 79 cases of NEN of the liver diagnosed between January 2011 to December 2015 were analyzed. WHO 2010 classification of GEP NEN was applied and the tumors were graded as G1, G2 or G3. Two more categories, D1/2 (discordant 1/2) and D2/3 (discordant 2/3) were also applied. The D1/2 grade tumors had a mitotic count of G1 and Ki-67 index of G2. The D2/3 tumors had a mitotic count of G2 and Ki-67 index of G3. The follow up details which were available till the end of the study period (December 2015) were collected.RESULTSOf the 79 tumors, 16 each were G1 and G2, and 18 were G3 tumors. Of the remaining 29 tumors, 13 were assigned to D1/2 and 16 were D2/3 grade. Male preponderance was noted in all tumors except for G2 neoplasms, which showed a slight female predilection. The median age at presentation was 47 years (range 10-82 years). The most common presentation was abdominal pain (81%). Pancreas (49%) was the most common site of primary followed by gastrointestinal tract (24.4%) and lungs (18%). Radiologically, 87% of the patients had multiple liver lesions. Histopathologically, necrosis was seen in only D2/3 and G3 tumors. Microvascular invasion was seen in all grades. Metastasis occurred in all grades of primary NEN and the grades of the metastatic tumors and their corresponding primary tumors were similar in 67% of the cases. Of the 79 patients, 36 had at least one follow up visit with a median duration of follow up of 8.5 mo (range: 1-50 mo). This study did not show any impact of the grade of tumor on the short term clinical outcome of these patients.CONCLUSIONLiver biopsy is an important tool for clinicopathological characterization and grading of NEN, especially when the primary is not identified. Eighty-seven percent of the patients had multifocal liver lesions irrespective of the WHO grade, indicating a higher stage of disease at presentation. Follow up duration was inadequate to derive any meaningful conclusion on long term outcome in our study patients.

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“…Primary hepatic NETs may account for 1% of endocrine primaries of the gastrointestinal tract (6,22). Most of these tumours are non-functioning and well-differentiated.…”

Section: Incidence By Sitementioning

confidence: 99%

Endocrine Tumours: Epidemiology of malignant digestive neuroendocrine tumours

Lepage

Bouvier

Faivre

2013

European Journal of Endocrinology

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Little is known about patients with malignant digestive neuroendocrine tumours (MD-NETs). Although their incidence is increasing, MD-NETs remain a rare cancer, representing 1% of digestive cancers. Most MD-NETs are well-differentiated. MD-NET poorly differentiated carcinomas account for 20% of cases on average. Anatomical localisation of MD-NETs varied according to geographic region. Stage at diagnosis and prognosis for patients with MD-NETs in the general population are considerably worse than often reported from small hospital case series. Prognosis varies with tumour differentiation, anatomic site and histological subtype. There are significant differences in survival from MD-NETs among European countries, independent of other prognostic factors. Early diagnosis is difficult; new therapeutic options appear to represent the best approach to improving prognosis.

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Primary endocrine tumours of the liver

Abstract: Primary hepatic endocrine tumours were identified in almost 5 per cent of patients with digestive endocrine tumours. Poor differentiation was the only factor associated with unfavourable outcome.

Cited by 14 publications

References 32 publications

Predictors of Long-Term Survival After Liver Transplantation for Metastatic Endocrine Tumors: An 85-Case French Multicentric Report

Predictors of Long-Term Survival After Liver Transplantation for Metastatic Endocrine Tumors: An 85-Case French Multicentric Report

Neuroendocrine neoplasms of liver - A 5-year retrospective clinico-pathological study applying World Health Organization 2010 classification

Endocrine Tumours: Epidemiology of malignant digestive neuroendocrine tumours

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