Primary endometrioid carcinoma of the uterosacral ligament arising from deep infiltrating endometriosis 6 years after bilateral salpingo-oophorectomy due to atypical proliferative endometrioid tumor of the ovary: a rare case report

Ota, Yoshiaki; Ota, Kuniaki; Takahashi, Toshifumi; Suzki, Soichiro; Sano, Rikiya; Ota, Ikuko; Moriya, Takuya; Shiota, Mitsuru

doi:10.1186/s12957-020-02105-1

Cited by 8 publications

(3 citation statements)

References 23 publications

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“…Both patients had a history of endometriosis/adenomyosis [6]. A rare endometrioid carcinoma developed from deep infiltrating endometriosis in the uterosacral ligament six years after treatment for an atypical proliferative endometrioid tumor of the ovary in a 48-year-old woman reported [7].…”

Section: Discussionmentioning

confidence: 99%

Primary Broad Ligament Endometroid Adenocarcinoma: A Case Report and Review of Literature

Gupta¹

2023

JGynecolCaseRep

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Since the broad ligament is closely related to other structures, such as the uterus, fallopian tubes, and ovaries, secondary involvement of it due to primary malignancy elsewhere is common. Primary broad ligament malignancies are rare. Only 29 cases of primary broad ligament malignancies have been reported in the literature, out of which only 5 cases of endometrioid adenocarcinoma [1]. Generally, the primary broad ligament tumor diagnosis is made retrospectively, intraoperatively, or on histopathological examination, due to its rarity. I have encountered a case where laparotomy and myomectomy were planned with a preoperative diagnosis of large subserous leiomyoma and intramural leiomyoma. Per operatively large friable mass was present between 2 leaves of the broad ligament on the right side, and a large adenomyoma was present in the posterior wall of the uterus. Subsequently, adenomyomectomy and excision of the broad ligament mass was done. On histopathology, the broad ligament mass was diagnosed as endometroid adenocarcinoma, and the uterine mass as an adenomyoma.

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Section: Discussionmentioning

confidence: 99%

Primary Broad Ligament Endometroid Adenocarcinoma: A Case Report and Review of Literature

Gupta¹

2023

JGynecolCaseRep

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“…It also inhibit the migration and invasion of endometriotic cells. It disrupts the dynamics of the cytoskeleton, preventing the rearrangement and extension of cellular structures necessary for cell movement thus it helps to limit the spread and dissemination of endometriotic lesions (Ota et al, 2020).…”

Section: Phytochemicals Reported For Management Of Endometriosismentioning

confidence: 99%

Indian Medicinal Plants for the Management of Endometriosis: A Comprehensive Review on their phytopharmacology

Ekbbal,

Jaiswal,

Aggarwal

et al. 2023

NRFHH

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Endometriosis is a chronic gynecological disorder characterized by the aberrant growth of endometrial tissue outside the uterus, resulting in severe pain and infertility. Conventional treatments often come with limitations and side effects, prompting a quest for alternative therapies. Medicinal plants, integral to traditional medicine systems, have emerged as potential solutions. This review delves into the phytopharmacology and chemistry of medicinal plants employed in endometriosis treatment. An exhaustive search revealed pertinent studies concerning medicinal plant use in endometriosis treatment. These studies were scrutinized for their phytopharmacological attributes and active chemical constituents. Numerous medicinal plants exhibited anti-inflammatory, analgesic, antioxidant, immunomodulatory, and hormone-regulating properties, pivotal in endometriosis management. Mechanisms encompassed the suppression of inflammatory mediators, modulation of estrogen signaling, mitigation of oxidative stress, and enhancement of immune function. Furthermore, key chemical constituents responsible for these effects were pinpointed and classified into classes such as flavonoids, terpenoids, alkaloids, and phenolic compounds. These bioactive agents elicited their actions via diverse molecular targets, including cyclooxygenase enzymes, estrogen receptors, nuclear factor-kappa B, and reactive oxygen species. The findings underscore the potential of medicinal plants as adjunct therapies for endometriosis. Nonetheless, additional preclinical and clinical investigations are imperative to substantiate their efficacy, safety, and optimal dosing. Grasping the phytopharmacology and chemistry of medicinal plants in endometriosis treatment lays the groundwork for novel therapeutic agent development, spotlighting the capacity of natural products to combat this intricate gynecological ailment.

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“…Some cases, despite usually being case reports, underline the complexity of the endometriosis-cancer relationship. A case of primary endometrioid carcinoma arising from deep infiltrating endometriosis 6 years after diagnosis of ovarian cancer [14] can serve as an example. Similar case reports do not provide any meaningful information about the mechanisms of action or pathology of cancer development, but strongly suggest the need for long-term follow-up for survivors of ovarian cancer with co-existent endometriosis.…”

Section: Introductionmentioning

confidence: 99%

Endometriosis and gynaecological cancers: molecular insights behind a complex machinery

Větvička¹,

Fiala²,

Garzon³

et al. 2021

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Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal women, with a prevalence of 10-16% of women of reproductive age. Despite over century of intensive research, none of the current treatment options represents a real cure. Based on the current knowledge, endometriosis, particularly its atypical version, is considered to be a transitional form from benign disease to tumour. However, the exact mechanisms of this conversion are still not fully established.

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Primary endometrioid carcinoma of the uterosacral ligament arising from deep infiltrating endometriosis 6 years after bilateral salpingo-oophorectomy due to atypical proliferative endometrioid tumor of the ovary: a rare case report

Cited by 8 publications

References 23 publications

Primary Broad Ligament Endometroid Adenocarcinoma: A Case Report and Review of Literature

Primary Broad Ligament Endometroid Adenocarcinoma: A Case Report and Review of Literature

Indian Medicinal Plants for the Management of Endometriosis: A Comprehensive Review on their phytopharmacology

Endometriosis and gynaecological cancers: molecular insights behind a complex machinery

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