Primary Ependymoma of the Ovary, in Which Long-Term Oral Etoposide (VP-16) Was Effective in Prolonging Disease-Free Survival

Mikami, Mikio; Komuro, Yuuki; Sakaiya, Naoko; Tei, Chisei; Kurahashi, Takashi; Komiyama, Shinichi; Hirose, Takanori

doi:10.1006/gyno.2001.6343

Cited by 17 publications

(20 citation statements)

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“…Recurrences have been reported to occur from 6mo to up to 30 yr after the initial detection of an extraneural ependymoma (2–6,9,11,12,14,21,23,30). Rarely patients have been reported to have died of disease, after multiple recurrences (2,9) or delayed treatment of bulky disease (19).…”

Section: Discussionmentioning

confidence: 99%

Pelvic Ependymoma With Clinical Response to GnRH Analog Therapy

Zhou

Song

Mikolaenko

et al. 2015

International Journal of Gynecological Pathology

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Summary Extraneural ependymomas are rare tumors that occur in sacrococcygeal, pelvic and extra pelvic regions. While sacrococcygeal extraneural ependymomas are equally distributed among males and females, pelvic and extra pelvic ependymomas have been exclusively reported in women, mainly of child bearing age. We present a case of extraneural, pelvic ependymoma that showed clinical response to GnRH therapy with its immunohistochemical and electron microscopic analysis, and an overview of primary extraneural ependymomas based on a review of all such cases published in English literature.

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Section: Discussionmentioning

confidence: 99%

Pelvic Ependymoma With Clinical Response to GnRH Analog Therapy

Zhou

Song

Mikolaenko

et al. 2015

International Journal of Gynecological Pathology

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“…Extraaxial ependymomas are also believed to derive from progenitor cells, and their occurrence in teratomas seems to support this view. 3,8,21 A progenitor cell hypothesis could therefore also be suggested to explain CEs, but whether such progenitor cells result from a migration defect of subependymal neural progenitors remains to be established.…”

Section: Discussionmentioning

confidence: 99%

Cortical ependymoma: an unusual epileptogenic lesion

Gompel¹,

Koeller

Meyer³

et al. 2011

JNS

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Object Supratentorial cortical ependymomas (CE) are rare, with 7 cases reported. The lesions, typically occurring in the superficial cortex in young adults and associated with a history of seizures, are not fully characterized. Furthermore, their relationship with the recently described angiocentric glioma (AG) is still being debated. This study was undertaken to summarize the authors’ experience with CEs. Methods Between 1997 and 2009, 202 cases of ependymoma were surgically treated at the Mayo Clinic, 49 of which were supratentorial. Among these, 9 CE cases were retrospectively identified. Clinical, imaging, and pathological features of each case were reviewed. Results Tumors arose from the frontal (5 cases), parietal (3), and occipital (1) lobes. No tumor occurred in the temporal lobe, despite its reported association with seizures. The mean age at presentation was 27 ± 19 years (± SD) and age at resection was 36 ± 16 years. The mean size of the lesion was 16 ± 14 cm3. Seizures were the presenting symptom in 78%. Cross-sectional imaging in 8 cases was characterized by a heterogeneous mass with multiple cystlike areas and enhancement of the soft-tissue component. Gross-total resection was achieved in 8 of 9 tumors. Pathologically, 6 were low-grade (WHO Grade II) and 3 were anaplastic (WHO Grade III) ependymomas. All tumors exhibited the focal presence of perivascular pseudorosettes, but only 1 (11 %) exhibited the focal presence of a true rosette. A bipolar spindle cell component resembling AG was present in 3 (33%) and “Schwannian-like” nodules in 2 (22%). Subpial aggregation and peripheral infiltration were present in 4 cases (44%}. With a mean postsurgery follow-up of 62 ± 38 months, only 2 lesions recurred locally after imaging-confirmed gross-total resection, both being Grade III. In 5 (71 %) of 7 patients presenting with seizures an Engel Class I outcome was achieved. Conclusions Cortical ependymomas represent a rare type of ependymoma occurring superficially in the cortex. Morphologically, these tumors are protean, varying from classic to epithelioid, clear cell, and tanycytic. Some also exhibited features typical of AG. Most tumors were low grade and cured with resection. Anaplastic tumors occur and may recur locally despite provision of radiation therapy. Cortical ependymomas frequently, but not always, present with seizures, but despite their high association with epilepsy, none occurred in the temporal lobe in any of the authors’ 9 patients. Overall, CEs appear to have a relatively favorable prognosis compared with other supratentorial ependymomas.

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“…They are found rarely only in the female genital tract; to date, only 16 cases have been reported in the ovary [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] and 3 [18,19] in the broad ligament, and none of these cases originated unequivocally from a preexistent mature teratoma.…”

Section: Introductionmentioning

confidence: 99%