Primary Epidural Peripheral Primitive Neuroectodermal Tumor of the Thoracic Spine  -Case Report-

Kiatsoontorn, Kraiyot; Takami, Toshihiro; Ichinose, Tsutomu; Chokyu, Isao; Tsuyuguchi, Naohiro; Ohsawa, Masahiko; Ohata, Kenji

doi:10.2176/nmc.49.542

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…After reviewing literatures, the authors concluded that no evidence was shown that craniospinal axis radiation was more effective than local radiation, and cisplatin-based combination chemotherapy may be the first-line treatment in recurrent or refractory Ewing sarcoma tumors. [ 12 ] In a case report with literature review, Sharma et al concluded that maximal safe resection followed by aggressive chemoRT appeared to be the standard treatment. In this study, they also mentioned that because RT could be detrimental to the spinal cord, especially in the pediatric age group, intensity-modulated radiation, and proton beam RT have received attention, which are known to have better dose distribution.…”

Section: Discussionmentioning

confidence: 99%

Recurrent spinal primitive neuroectodermal tumor with brain and bone metastases

Chen¹,

Chiou²,

Lin³

et al. 2017

Medicine

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Rationale:Primary spinal primitive neuroectodermal tumor (PNET) is relatively rare in all age groups, and the prognosis in most cases of spinal PNETs appears to be poor, with a median patient survival of 1 to 2 years. We present a case with recurrent spinal PNET with brain and bone metastases that was successfully treated by multimodality treatment.Patient concerns:A 14-year-old teenage girl had suffered from progressive left upper back pain with bilateral lower legs weakness and numbness for 1 year. After treatment, left neck mass was noted 3 years later.Diagnoses:Initially, magnetic resonance imaging (MRI) showed neurogenic tumor involving intradural extramedullary space of T5-T10. Pathology report showed PNET (World Health Organization grade IV) featuring lobules of neoplastic cells with round regular nuclei, high nucleus-to-cytoplasm ratio, and fibrillary cytoplasm. At the time of tumor recurrence, chest MRI then showed recurrent tumor at T2-T3 level of the epidural space with right neural foramina invasion. Brain MRI showed extensive bilateral calvarial metastases and leptomeningeal metastases in the right frontoparietal regions. Bone scan showed multiple bone metastases.Interventions:T-spine tumor removal and adjuvant radiotherapy (RT) to T-spine tumor bed were performed in the initial treatment. After clinical tumor recurrence, tumor removal was done again. She then received chemotherapy followed by whole brain irradiation with hippocampal sparing with 35 gray in 20 fractions.Outcomes:After treatment, follow-up images showed that the disease was under control. There was no neurological sequela. She has survived more than 7 years from diagnosis and more than 4 years from recurrence to date.Lessons:Multimodality treatments including operation, RT, and chemotherapy should be considered in the initial treatment planning, and salvage chemotherapy was useful in this case.

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Section: Discussionmentioning

confidence: 99%

Recurrent spinal primitive neuroectodermal tumor with brain and bone metastases

Chen¹,

Chiou²,

Lin³

et al. 2017

Medicine

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“…The possibility of primitive neuro ectodermal tumour to disseminate along the neuraxis supports prophylactic craniospinal irradiation with an involved boost to the primary site. 7-9 …”

Section: Discussionmentioning

confidence: 99%

Primary spinal primitive neuroectodermal tumour – a case report

Sundar

Pandian

Kumar

2013

ANS

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Primitive neuroectodermal tumours (PNET) are aggressive childhood malignancies and offer a significant challenge to treatment. A two years old female child presented with weakness both lower limbs. Preoperative MRI of the spine and paravertebral regionIso – hyper intense posterior placed extradural lesion, non contrast enhancing from D11-L2 levels with cord compression D9 to L3 laminectomy done. Granulation tissue found from D11 to L2. with cord compression. The granulation tissue removed in toto. The pathological findings were consistent with PNET. Post operative neurological improvement was minimal. Cranial screening ruled out any intracranialtumour. Hence a diagnosis of primary spinal PNET was made. A review of the literature shows that only 19 cases of primary intraspinal PNETs have been reported to date and the present case extradural in location. Primary intraspinal PNETs are rare tumors and carry a poor prognosis.

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“…Bazı yazarlar ekstradural bölgeye sınırlı, kraniyospinal yayılımı olmayan olgularda lokal radyoterapinin yeterli olabileceğini bildirmişlerdir. [17] Radyoterapi sahası ile birlikte radyoterapi dozu da tartışmalıdır. Albrecht ve ark.…”

Section: Discussionunclassified

The vaccine injection sites mimicking metastases of malignant melanoma on FDG PET

2012

TJ Oncol

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Primer intramedüller nöroendokrin tümör (PNET) oldukça ender görülür; bu tümörler genellikle çocuklarda görülür ve ender olarak merkezi sinir sistemine metastaz yapabilirler. Bu bölgeden çıkan tümörler intramedüller, ekstramedüller, intraekstramedüller ve ekstradural kaynaklı olabilir. Araştırmamıza göre literatürde bugüne kadar 25 tane intramedüller PNET olgusu bildirilmiştir. Bu yazıda, intramedüller bir olgu sunuldu. PNET hastalarında başlangıç tedavisi cerrahi olup, mümkünse tümör tamamen çıkarılmalıdır. Radyoterapi ve kemoterapinin eklenmesi hastalarda avantaj sağladığı düşünülmüştür.Anahtar sözcükler: İntramedüller primitif nöroendokrin tümör; kemoterapi; radyoterapi.Primitive neuroendocrine tumors (PNETs) are rare neoplasms that are usually seen in children and frequently metastasis in the central nervous system. At this setting, intramedullary, extramedullary, intra-extramedullary and extradural have been described. To our knowledge, only 25 cases of purely intramedullary PNETs (IPNETs) have been previously reported. We present a case of primary intrameduller PNET. The initial treatment of the PNET is surgery and, if possible, the radical extirpation of the tumour. Administration of radiotherapy and chemotherapy appears to increase survival.

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Primary Epidural Peripheral Primitive Neuroectodermal Tumor of the Thoracic Spine -Case Report-

Cited by 6 publications

References 18 publications

Recurrent spinal primitive neuroectodermal tumor with brain and bone metastases

Recurrent spinal primitive neuroectodermal tumor with brain and bone metastases

Primary spinal primitive neuroectodermal tumour – a case report

The vaccine injection sites mimicking metastases of malignant melanoma on FDG PET

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