Primary epithelioid hemangioendothelioma originating in the lower petroclival region: case report

Watanabe, Takashi; Saito, Nobuhito; Shimaguchi, Hidetoshi; Fujimaki, Hiroya; Kamiya, Makoto; Nakazato, Yoichi; Sasaki, Tomio

doi:10.1016/s0090-3019(03)00068-5

Cited by 19 publications

(20 citation statements)

References 30 publications

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“…Although several cases have been documented in the head and neck region, cases in the skull base region are rare. In our review of the literature, only two cases of EHE of the clival region have been reported 6,7 . Here we report a third EHE in the clival region and also review the literature.…”

Section: Introductionmentioning

confidence: 75%

Primary epithelioid hemangioendothelioma in the clival region: A case report and literature review

Ma¹,

Xu³

et al. 2010

Neuropathology

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Epithelioid hemangioendothelioma (EHE) is a rare and low-grade vascular tumor, which usually occurs in the soft tissue, liver, breast, lung and skeleton. Here we submit a case with EHE of the clival region. A 58-year-old woman was admitted with a medical history of 3 months headache and 1 month visual deterioration. MRI revealed a well-circumscribed mass of 4.0 cm × 3.0 cm with bony invasion. The tumor was subtotally removed in a piecemeal fashion. Histologically, the tumor was composed of epithelioid cells with eosinophilic cytoplasm and intracytoplasmic vacuoles. Immunohistochemically, the tumor cells were positive for the markers CD31, CD34, factor VIII and vimentin. The pathological result was interpretated as EHE of the clival region. EHE is an uncommon vascular tumor, which is rarely seen in the clival region. Definitive diagnosis depends on histopathologic and immunohistochemical features.

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Section: Introductionmentioning

confidence: 75%

Primary epithelioid hemangioendothelioma in the clival region: A case report and literature review

Ma¹,

Xu³

et al. 2010

Neuropathology

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“…They have been best described in the liver, lung, breast, and bone [2–5]. Intracranial involvement has been described in 36 cases and only 4 other cases of posterior fossa EHs [9, 10, 12, 13]. The risk of malignancy, recurrence, and mestastases and a variable clinical course led to appropriate pathological identification and rigorous follow-up paramount.…”

Section: Discussionmentioning

confidence: 99%

Epithelioid Hemangioendothelioma of the Mastoid: Resection for Recurrence and Adjuvant Radiation with 8-Year Followup

Drazin

Gandhi

Slodkowska

et al. 2013

Case Reports in Surgery

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Epithelioid hemangioendothelioma (EH) is a rare, vascular neoplasm that can affect any age group and has been reported previously in sites including bone, liver, lung, breast, and brain. We describe a case of EH located in the mastoid, which appears to be the first report of EH in this site. The patient was 62 years old when they presented with dizziness and nausea. A suboccipital surgical approach was utilized to resect the tumor. After 18-month followup, the patient was symptom-free; however, imaging demonstrated a recurrence and the patient was taken back to the operating room for a resection. There is no evidence of recurrence after 8 years of followup. This paper aims to reinforce the need for a timely radical excision and aggressive clinical followup as the best hope for cure. Here, we describe an illustrative case and review the pertinent literature.

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“…On CT and magnetic resonance imaging (MRI), EHE is characterized by a well-demarcated, osteolytic and expansile lesion involving the skull bone, which has the sclerotic edges specks of calcification [4][5][6][7] giving rise to a honeycomb configuration with trabeculation [7,8] malignant EHE may be similar to that of a benign lesion . Although the imaging pattern of [9] , Unni, et al have described a positive correlation between the radiographic picture and the histological grade [10] .…”

Section: Discussionmentioning

confidence: 99%

“…The histopathological features considered suggestive of more aggressive clinical behavior include a mitotic rate more than one per 10 high-power fields, cellular atypia, focal necrosis, and increase in proportion of the spindle cells [1,4,11] . The treatment choice for hemangioendothelioma has been surgical resection, combined with radiation, especially in high-grade lesions [8,12] . Because of their extensive vascularity, EHE lesions can lead to substantial intraoperative bleeding with resultant mortality [13] .…”

Section: Discussionmentioning

confidence: 99%

Malignant hemangioendothelioma of occipital bone

Agrawal¹,

Bhake²,

Banode³

et al. 2012

Chin. J. Cancer Res.

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Epithelioid hemangioendothelioma is a rare vascular tumor of bone, and rarely these lesions can present as unique and extremely aggressive tumor. We report a case of highly aggressive epithelioid hemangioendothelioma and discuss the imaging findings. CT brain plain study revealed a poorly-defined, mixed density expansile and lytic lesion involving the occipital bone with extension to the left side with poorly defined trabecula formation. There was significant but irregular enhancement after intravenous administration of contrast material and also marked bone destruction. Microscopic examination of the fine needle aspiration cytology showed a tumor composed of vascular channels lined by plump endothelial cells, which had enlarged hyperchromatic nuclei. In view of the extensive infiltration the patient was submitted for the radiotherapy.

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Primary epithelioid hemangioendothelioma originating in the lower petroclival region: case report

Cited by 19 publications

References 30 publications

Primary epithelioid hemangioendothelioma in the clival region: A case report and literature review

Primary epithelioid hemangioendothelioma in the clival region: A case report and literature review

Epithelioid Hemangioendothelioma of the Mastoid: Resection for Recurrence and Adjuvant Radiation with 8-Year Followup

Malignant hemangioendothelioma of occipital bone

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