Primary esophageal diffuse large B cell lymphoma presenting with tracheoesophageal fistula: A rare case and review

Teerakanok, Jirapat; DeWitt, Judy Park; Juarez, Edna; Thein, Kyaw Zin; Warraich, Irfan

doi:10.4251/wjgo.v9.i10.431

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…The 1- and 2-year overall survival rates were 62.5% and 25%, respectively, during follow-up in the current study. Patients with PEL may present with tracheoesophageal fistula or develop this kind of fistula as a complication as what happened in our case [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 65%

Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia

Al-Maghrabi

2023

Gastroenterology Research and Practice

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Background. Primary esophageal lymphoma (PEL) is a rare disorder. The objective of this study was to document the clinicopathological features of PEL at two tertiary hospitals in the western region of the Kingdom of Saudi Arabia. Methods. All PELs diagnosed between May 2002 and June 2022 were retrieved. Histopathological and immunohistochemical slides were reviewed. Additional immunohistochemistry stains were performed in selected cases. Follow-up data were collected. Results. There were only eight cases of PEL in the records of the two hospitals. The age of the patients ranged between 50 and 74 years (median 62 years and mean 62.5 years). There were six males (80%) and two females (20%). None of the patients were immunocompromised or had human immunodeficiency virus (HIV) infection. The clinical manifestation included dysphagia and loss of weight. Six cases were diffuse large B-cell lymphoma (DLBCL), and two were low-grade mucosa-associated lymphoid tissue lymphoma. Conclusion. PEL is an extremely rare disease with male predominance. DLBCL is the most common pathological type in our community. There was no relation to immune status or HIV infection in this series. Clinical presentations were typically dysphagia with weight loss. Further reporting of PEL cases might help explain this disease and improve its diagnosis and management.

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Section: Discussionmentioning

confidence: 65%

Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia

Al-Maghrabi

2023

Gastroenterology Research and Practice

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“…The development of a respiratory-digestive tract fistula can be found in adult malignancies, particularly with lymphoma 5. The type of fistula usually depends on the location of matted lymph nodes, resulting in tracheo-oesophageal, broncho-oesophageal, gastrobronchial or gastropleural fistulas 6–14. The GPF is quite a rare complication even in adults.…”

Section: Discussionmentioning

confidence: 99%

Gastropleural fistula masquerading as chylothorax in a child with lymphoma

et al. 2019

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We report the case of an 8-year-old boy with diffuse large B cell lymphoma who developed a right-sided spontaneous pneumothorax with pleural effusion after recovery from septic shock. The pleural fluid was thought to be malignancy-associated chylothorax concomitant with complicated pleural effusion due to a milky-like appearance, a high level of triglycerides and Gram-negative bacteria staining in the fluid. He was put on total parental nutrition and octreotide for 2 weeks, but did not improve. The laboratory results also showed a persistent bacterial infection in the pleural fluid despite appropriate antibiotics. Eventually, a CT scan revealed a fistulous tract between the right pleural cavity and the stomach. Fistula repair was successful by right open thoracotomy with decortication. Even though the gastropleural fistula is a very rare condition in paediatric patients, the physician should consider this diagnosis in a patient who has an unusual presentation or refractory chylothorax-like pleural effusion.

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“…In this paper, the clinical data of 15 cases of primary esophageal lymphoma were collected and analyzed retrospectively, in which one case was admitted to our institution and 14 cases were reported in the literatures [2][3][4][5][6][7][8][9][10][11][12][13][14]. To improve the diagnosis and treatment of this disease, a systematic analysis was carried out, highlighting the clinical, endoscopic, and pathological features.…”

Section: Introductionmentioning

confidence: 99%

Primary Esophageal Lymphoma: Clinical Experience in Diagnosis and Treatment

Zhuang

Zheng

et al. 2021

Cureus

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Primary esophageal lymphoma is a rare malignant tumor, which is often misdiagnosed. To improve the diagnosis and treatment of this disease, we presented one case admitted at our institution and a literature review of primary esophageal lymphoma cases, including the clinical data, features of imaging, endoscopy and pathology, treatment, and prognosis. The symptoms were non-specific. Under endoscopy, most of the lesions were located in the middle and lower segment of the esophagus, behaving as ulcers, polyps, or submucosal masses, always accompanying with esophageal stricture. The diagnosis of primary esophageal lymphoma was highly dependent on pathological and immunohistochemical examination, hence stacked sampling was suggested to improve the positive rate of mucosal biopsy. Combination of chemotherapy and radiotherapy may be the first choice of treatment, surgical and endoscopic resections may be an alternative solution as well. The therapeutic effect and prognosis were slightly better than those of other esophageal malignant tumors.

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Primary esophageal diffuse large B cell lymphoma presenting with tracheoesophageal fistula: A rare case and review

Cited by 8 publications

References 28 publications

Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia

Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia

Gastropleural fistula masquerading as chylothorax in a child with lymphoma

Primary Esophageal Lymphoma: Clinical Experience in Diagnosis and Treatment

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