Primary esophageal mucosa‐associated lymphoid tissue lymphoma treated by endoscopic submucosal dissection

Kudo, Kenji; Ota, Masaho; Narumiya, Kosuke; Shirai, Yuji; Ohki, Takeshi; Yamamoto, Masakazu

doi:10.1111/den.12138

Cited by 10 publications

(6 citation statements)

References 10 publications

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“…The present case showed both of these endoscopic findings, and we additionally observed the presence of abnormal blood vessels similar to a tree-like appearance, which is a typical characteristic of gastric lesions in MALT lymphoma (39, 40). This characteristic was recently reported in an esophageal lesion by Kudo et al (25). These radiological and endoscopic characteristics may be helpful in detecting esophageal MALT lymphoma lesions, and should prompt endoscopists to perform a biopsy to obtain specimens for histological examination.…”

Section: Discussionsupporting

confidence: 80%

The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after <i>Helicobacter pylori </i>Eradication Therapy: A Case Report and Discussion of Therapeutic Options

Takeuchi¹,

Miyahara²,

Morito

et al. 2019

Intern. Med.

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A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment.

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Section: Discussionsupporting

confidence: 80%

The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after <i>Helicobacter pylori </i>Eradication Therapy: A Case Report and Discussion of Therapeutic Options

Takeuchi¹,

Miyahara²,

Morito

et al. 2019

Intern. Med.

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“…Lymphoma was localized in the esophagus in 15 cases, and the remaining patient had involvement of the stomach ( 4 ). In patients with localized disease, esophageal MALT lymphoma can be curatively removed by surgical resection ( 9 , 19 , 25 ) or endoscopic resection ( 6 , 14 , 20 ), as shown in our present patient. Previous studies have demonstrated that endoscopic resection alone resulted in complete remission for 1 year, 22 months, and 2 years after resection.…”

Section: Discussionsupporting

confidence: 62%

Primary Localized Esophageal Mucosa-associated Lymphoid Tissue Lymphoma Treated by Endoscopic Submucosal Dissection

et al. 2018

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A 69-year-old Japanese woman presented to our hospital for the further investigation of an esophageal subepithelial tumor. A diagnosis of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) was made by an endoscopic biopsy. The patient had no involvement other than the esophagus. The tumor was resected using endoscopic submucosal dissection. Lymphoma recurrence has not been documented in the 57 months since resection. This case suggests that although a detailed preoperative evaluation is required to determine the extent of tumor, endoscopic resection may be an option for the long-term disease control of MALT lymphoma of the esophagus.

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“…Some had non-specific symptoms and the esophageal lesion was detected during a routine medical check-up. [15] Several approaches, such as endoscopic examination, endosonography of the upper gastrointestinal tract, and chest CT scan, were used to examine the esophageal lesion in clinical practice. However, it was difficultly to confirm the diagnosis of esophageal MALT lymphoma through these methods.…”

Section: Discussionmentioning

confidence: 99%

Primary esophageal mucosa-associated lymphoid tissue lymphoma

Zhang

Fang

et al. 2017

Medicine

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Rationale:Mucosa-associated lymphoid tissue (MALT) lymphoma is a low grade malignant B cell lymphoma which occurs mainly in the organs having mucosal layer. Though gastrointestinal tract is the most commonly involved extranodal site, primary esophageal MALT lymphoma is very rare with less than 20 cases reported in literature.Patient concerns:A 75-year-old man was referred to our hospital for evaluation of dysphagia. Endoscopy revealed a submucosal tumor located in the middle and lower third of esophagus. CT chest and endoscopic ultrasound revealed a 15.5 × 5.9 × 4.0 cm well circumscribed submucosa esophageal tumor. Test for serum antibody against H. pylori was negative. Due to the large tumor size, patient underwent surgical resection. Histological examination showed a submucosal tumor consisting of multiple nodules of varying sizes with intact covering squamous epithelium. The nodules were mainly composed of diffusely and monoclonal proliferating centrocyte-like or monocyte-like cells. Follicular colonizations were observed without lymphoepithelial lesions. The tumor cells were diffusely positive for CD20, PAX-5, Bcl-2 and follicular dendritic cells were positive for CD21, CD23. Monoclonal gene rearrangement was positive for immunoglobulin heavy chain gene, Kappa light chain gene and Lambda light chain gene.Diagnoses:Based on these findings, final diagnosis of esophageal MALT lymphoma was made.Outcomes:At 8 month follow up, no recurrence or metastases was detected.Lessons:Esophageal MALT lymphoma is a rare disease with definitive diagnosis possible only after histopathological examination. It carries good prognosis due to low malignant potential.

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Primary esophageal mucosa‐associated lymphoid tissue lymphoma treated by endoscopic submucosal dissection

Cited by 10 publications

References 10 publications

The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after <i>Helicobacter pylori </i>Eradication Therapy: A Case Report and Discussion of Therapeutic Options

The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after <i>Helicobacter pylori </i>Eradication Therapy: A Case Report and Discussion of Therapeutic Options

Primary Localized Esophageal Mucosa-associated Lymphoid Tissue Lymphoma Treated by Endoscopic Submucosal Dissection

Primary esophageal mucosa-associated lymphoid tissue lymphoma

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