Primary esophageal non-Hodgkin’s lymphoma: demographics, clinical characteristics, histopathologic types, and survival in 179 patients from the SEER program and systematic review of the literature

Quiroga-Centeno, Andrea Carolina; Parada, Ileana Rocío Bautista; Tapias, Luis F.; Gómez‐Ochoa, Sergio Alejandro

doi:10.1007/s10388-021-00842-0

Cited by 6 publications

(8 citation statements)

References 52 publications

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“…Six cases were DLBCL, and two were low-grade MALT lymphoma. Quiroga-Centeno et al [ 6 ] showed that male gender predominates via data obtained from Surveillance, Epidemiology, and End Results (SEER) study. The mean age at presentation of MALT lymphoma patients was 78.5 years, and the mean age at presentation of patients of the other histological type was 65 years.…”

Section: Discussionmentioning

confidence: 99%

“…Surgical and endoscopic resections could be a reasonable alternative approach according to histological type and initial site of the tumor. The median overall survival was 12 months with excellent prognosis of MALT lymphoma compared with DLBCL [ 6 ]. Other histological types of PEL have also been described in the literature including Burkitt's lymphoma [ 7 ], mantle cell [ 8 ], anaplastic [ 9 , 10 ], T-cell lymphoma [ 11 ], Hodgkin's lymphoma [ 2 , 12 ], and true histiocytic lymphoma [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

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Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia

Al-Maghrabi

2023

Gastroenterology Research and Practice

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Background. Primary esophageal lymphoma (PEL) is a rare disorder. The objective of this study was to document the clinicopathological features of PEL at two tertiary hospitals in the western region of the Kingdom of Saudi Arabia. Methods. All PELs diagnosed between May 2002 and June 2022 were retrieved. Histopathological and immunohistochemical slides were reviewed. Additional immunohistochemistry stains were performed in selected cases. Follow-up data were collected. Results. There were only eight cases of PEL in the records of the two hospitals. The age of the patients ranged between 50 and 74 years (median 62 years and mean 62.5 years). There were six males (80%) and two females (20%). None of the patients were immunocompromised or had human immunodeficiency virus (HIV) infection. The clinical manifestation included dysphagia and loss of weight. Six cases were diffuse large B-cell lymphoma (DLBCL), and two were low-grade mucosa-associated lymphoid tissue lymphoma. Conclusion. PEL is an extremely rare disease with male predominance. DLBCL is the most common pathological type in our community. There was no relation to immune status or HIV infection in this series. Clinical presentations were typically dysphagia with weight loss. Further reporting of PEL cases might help explain this disease and improve its diagnosis and management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia

Al-Maghrabi

2023

Gastroenterology Research and Practice

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“…Esophageal lymphoma is usually secondary to the metastasis of lymph nodes from the cervical and mediastinal region or local invasion from the stomach ( 1 ), and thus primary esophageal lymphoma (PEL) is extremely rare, which accounts for <1% of cases of all primary gastrointestinal lymphoma ( 2 ). The clinical manifestations of PEL are non-specific, which may vary based on symptoms such as dyspepsia, dysphagia, nausea, vomiting, abdominal distention, weight loss, fever, and even epigastric pain to massive hemorrhage ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

En Bloc Resection of Primary Large Esophageal Mucosa-Associated Lymphoid Tissue Lymphoma by Endoscopic Submucosal Dissection: A Case Report

et al. 2021

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Treatment of mucosa-associated lymphoid tissue (MALT) lymphoma has recently received considerable attention. Here, we report a case of large esophageal MALT lymphoma that was successfully en bloc resected using endoscopic submucosal dissection (ESD). A 77-year-old woman was admitted to our hospital with progressive dysphagia for more than 2 months. Upper gastrointestinal endoscopy revealed a large rounded submucosal mass covered by normal mucosa, located at the lower esophagus. Endoscopic ultrasonography (EUS) showed a well-demarcated hypoechoic mass chiefly located in the esophageal wall, but the layers of the esophageal wall were not clear. ESD was performed for diagnostic and treatment purposes. No complications occurred during or after ESD. The resected specimen measured 4.3 cm × 2.8 cm × 1.5 cm. The histologic findings were diagnostic of esophageal MALT lymphoma. Infiltration of neoplastic cells in the lateral margins of the resected specimen was not observed. However, vertical margins showed an R1 situation and mild damage to the muscularis propria. After 3 months, her dysphagia disappeared. Additional radiation therapy was then administered. After 5 months, the patient was still under surveillance and free of recurrent disease. Resection with ESD of such a large mass of MALT in the esophageal region has rarely been reported before in the literature.

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A case report of giant primary esophageal follicular lymphomaTo the Editor, Gastrointestinal (GI) lymphoma accounts for 30%-50% of all primary extranodal lymphomas, the majority of which are non-Hodgkin's lymphomas (NHL) with B-cell type predominance. 1,2 The stomach and small intestine are the most commonly affected sites of GI lymphomas, 1 whereas esophagus was affected in less than 1% of the cases. 3,4 Histologically, 70%-80% of extranodal marginal zone lymphomas are mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBCL).

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confidence: 99%

“…3,4 Histologically, 70%-80% of extranodal marginal zone lymphomas are mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBCL). 2,5 Approximately 9% of primary GI…”

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confidence: 99%

A case report of giant primary esophageal follicular lymphoma

Zhu

Lin

et al. 2022

J of Digest Diseases

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Primary esophageal non-Hodgkin’s lymphoma: demographics, clinical characteristics, histopathologic types, and survival in 179 patients from the SEER program and systematic review of the literature

Cited by 6 publications

References 52 publications

Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia

Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia

En Bloc Resection of Primary Large Esophageal Mucosa-Associated Lymphoid Tissue Lymphoma by Endoscopic Submucosal Dissection: A Case Report

A case report of giant primary esophageal follicular lymphoma

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