Primary Ewing′s sarcoma of the cranium: Case series and review of literature

Kalpathi, Krishnamani; Kumar, Thota Narender; Linga, Vijay Gandhi; Digumarti, Raghunadharao; Gundeti, Sadashivudu; Uppin, Megha S

doi:10.4103/0973-1482.136663

Cited by 19 publications

(19 citation statements)

References 15 publications

(18 reference statements)

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“…Female gender, the absence of systemic symptoms and metastasis at diagnosis, long duration of symptoms (more than six months), and peripheral tumor location are indicators of favorable prognosis [14]. Despite our patient having a 1-year duration of symptoms and absence of metastasis at diagnosis, this was not the patient's reported experience.…”

Section: Discussionmentioning

confidence: 82%

Primary Occipital Ewing’s Sarcoma with Subsequent Spinal Seeding

Alqahtani

Amer

Bakhsh

2017

Case Reports in Pediatrics

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Ewing's sarcoma is a primary bone cancer that mainly affects the long bones. This malignancy is particularly common in pediatric patients. Primary cranial involvement accounts for 1% of cases, with occipital involvement considered extremely rare. In this case study, primary occipital Ewing's sarcoma with a posterior fossa mass and subsequent relapse resulting in spinal seeding is reported. A 3-year-old patient presented with a 1-year history of left-sided headaches, localized over the occipital bone with progressive torticollis. Computed tomography (CT) imaging showed a mass in the left posterior fossa compressing the brainstem. The patient then underwent surgical excision followed by adjuvant chemoradiation therapy. Two years later, the patient presented with severe lower back pain and urinary incontinence. Whole-spine magnetic resonance imaging (MRI) showed cerebrospinal fluid (CSF) seeding from the L5 to the S4 vertebrae. Primary cranial Ewing's sarcoma is considered in the differential diagnosis of children with extra-axial posterior fossa mass associated with destructive permeative bone lesions. Although primary cranial Ewing's sarcoma typically has good prognosis, our patient developed metastasis in the lower spine. Therefore, with CNS Ewing's sarcoma, screening of the entire neural axis should be taken into consideration for early detection of CSF seeding metastasis in order to decrease the associated morbidity and mortality.

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Section: Discussionmentioning

confidence: 82%

Primary Occipital Ewing’s Sarcoma with Subsequent Spinal Seeding

Alqahtani

Amer

Bakhsh

2017

Case Reports in Pediatrics

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“…Primary Ewing's sarcoma (EWS) of the cranium is extremely rare and accounts for <1% of cases. 29 To date, only 71 cases have been reported in the English literature. 30 The most commonly involved bones of cranium include the frontal, occipital, and parietal bones and the base of the skull.…”

Section: Resultsmentioning

confidence: 99%

“…Primary Ewing's sarcoma (EWS) of the cranium is extremely rare and accounts for <1% of cases . To date, only 71 cases have been reported in the English literature .…”

Section: Discussionmentioning

confidence: 99%

Cytomorphological spectrum of scalp lesions in the population of a developing country: A retrospective study

Sharma

Pathak

Goyal

et al. 2019

Diagnostic Cytopathology

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BACKGROUND Scalp lesions are frequently encountered in clinical practice. Fine‐needle aspiration cytology (FNAC) can characterize most of these lesions; however, there is little published work on cytology of scalp lesions. METHODS Records of all the patients subjected to FNAC from January 2011 to August 2016 were retrieved from the archives of the Cytopathology section of our Institute. Out of the 71 852 cases reviewed, 896 patients, who presented with palpable scalp lesions, were included in the study. Aspirates were obtained with a 23‐gauge needle attached to a 10 mL disposable plastic syringe. May–Grünwald–Giemsa stained and Pap stained slides were prepared. Special stains and immunocytochemical analysis were done when necessary. RESULTS Out of the 896 cases of aspirates from scalp lesions, 155 (17.2%) aspirates were found to be inadequate for diagnosis. One hundred and fifty‐seven (21%) out of 741 adequate aspirates showed features of inflammatory or reactive pathology comprising of abscesses (57), cystic lesions (24), tubercular lesions (16), and reactive lymphadenopathy (66). Four hundred and fifteen (56%) aspirates revealed a tumor‐like etiology comprising of epidermal cyst (395), sebaceous cyst (4), dermoid cyst (1), calcinosis (7), vascular malformation (7), hematoma (5), and juvenile xanthogranulomatous lesion (1). Tumorous lesions formed 22.3% of the aspirates. Of these, 7 cases (4.2%) were of metastases to the scalp. CONCLUSION In a developing country, FNAC is a useful and cost‐effective investigation for the diagnosis of a wide spectrum of scalp lesions. It allows rapid diagnosis and permits timely intervention thereby preventing complications due to delay in diagnosis.

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“…The parieto-occipital region was the most common site. [4] About 90% of the cases occur in the first two decades of life, peak incidence is between 5 and 13 years of age, and males are affected more frequently. [2] Symptoms develop due to dural invasion, hydrocephalus, or raised intracranial pressure.…”

Section: Discussionmentioning

confidence: 99%

“…CT scan is useful to delineate bone involvement, and on MRI, the mass is hypo- to iso-intense on T1-weighted and iso- or hyper-intense on T2-weighted with heterogeneous enhancement on contrast. [4] On bone scintigraphy, an increased radioisotope uptake is seen.…”

Section: Discussionmentioning

confidence: 99%

Ewing’s Sarcoma of the Cranial Vault

Narayanan

Sreelesh

Somanathan

et al. 2016

Journal of Neurosciences in Rural Practice

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Primary Ewing's sarcoma (EWS) arising from cranial bones is rare and accounts for only 1%–4% of all EWS. We report the case of a 15-year-old girl with EWS of the frontoparietal region of the skull. She underwent excision following which she received combination chemotherapy with vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide, and VP16 and local radiation of 45 Gy. She is alive in complete remission at 40 months.

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Primary Ewing′s sarcoma of the cranium: Case series and review of literature

Cited by 19 publications

References 15 publications

Primary Occipital Ewing’s Sarcoma with Subsequent Spinal Seeding

Primary Occipital Ewing’s Sarcoma with Subsequent Spinal Seeding

Cytomorphological spectrum of scalp lesions in the population of a developing country: A retrospective study

Ewing’s Sarcoma of the Cranial Vault

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