Primary Ewing Sarcoma of Lumbar Spine With Massive Intraspinal Extension

Song, Xiufeng; Choi, Jai Ho; Rao, Chandrakant; Nallu, Sagarika; Nicastri, Anthony D.

doi:10.1016/j.pediatrneurol.2007.09.003

Cited by 18 publications

(11 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the lesion was diagnosed to be skeletal Ewing's sarcoma arising from the vertebral bone. Very few cases of skeletal Ewing's sarcoma of epidural extension have been documented as described by Song et al [6], although one report indicated that epidural extension was thought to be a common feature [3]. In addition, skeletal Ewing's sarcoma derived from the vertebral bone of epidural extension associated with intrathoracic extension through vertebral foramen in the present case is definitely rare.…”

Section: Discussionmentioning

confidence: 49%

Dumbbell-shaped Ewing’s sarcoma family of tumor of thoracic spine in a child

et al. 2008

View full text Add to dashboard Cite

An 8-year-old boy was referred due to difficulty in walking. T1-weighted MRI detected a well-marginated lesion expanding from the epidural region in the spinal canal to the paravertebral area through the Th9 and Th10 intervertebral foramen. The patient underwent a biopsy under video-assisted thoracoscopy and the tumor was diagnosed as Ewing's sarcoma family of tumor (ESFT). Imaging confirmed that the tumor completely disappeared and his neurologic functions were recovered perfectly at the end of treatment. Very few cases of skeletal ESFT of epidural extension in childhood have been documented. Video-assisted thoracoscopic surgery remains the best option for the diagnosis of endothoracic tumors in children.

show abstract

Section: Discussionmentioning

confidence: 49%

Dumbbell-shaped Ewing’s sarcoma family of tumor of thoracic spine in a child

et al. 2008

View full text Add to dashboard Cite

show abstract

“…This appearance is present in almost 100% of cases of ES and PNET [5]. The distinction between EES and other PNET is highly important and rests on histologic distinction (absence of Homer-Wright rosettes) and genetic confirmation [1, 7, 15, 16].…”

Section: Discussionmentioning

confidence: 99%

“…In our case, molecular diagnosis by FISH confirmed the fusion product. Common markers of ES include t(11; 22)(q24;q12), staining for strong membranous CD99 expression, and immunohistochemical detection of MIC-2 antigen expression [1, 4, 5, 17]. This translocation occurs between the EWS gene on chromosome 22q12 and the FLI1 gene on 11q24, leading to increased expression of ETS transcription factors and their downstream targets [17].…”

Section: Discussionmentioning

confidence: 99%

“…Chromosomal translocation t(11,22)(q24;q12) with the involvement of the EWSR1 gene is found on more than 90% of EES [1, 4, 18]. Additionally, this nonrandom translocation is found in 80–85% of cases and is recognized as the diagnostic gold standard for ES [5, 17, 19]. Both EES and primary CNS-PNET may stain for neuroendocrine markers; thus, CD56 and synaptophysin may be equivocal in distinguishing these entities.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Spinal Intradural Extraosseous Ewing Sarcoma in a Pediatric Patient: Case Report and Review of the Literature

et al. 2018

View full text Add to dashboard Cite

Ewing sarcoma (ES) is an aggressive, primary bone malignancy with occasional soft tissue extension. Purely extraosseous ES is rare. A primary intraspinal, intradural ES without bone involvement is exceedingly rare. ES may be differentiated from other primitive neuroectodermal tumors by molecular analysis. The authors report the case of a 14-year-old female who suffered an acute neurologic decline from a hemorrhagic, intraspinal, intradural ES. The patient has been tumor free for 2 years after the initial emergency surgery. Our management of the patient and a review of the literature are provided. Considering only those cases with molecular or genetic confirmation of ES, our patient is the fifth pediatric case reported in the English literature.

show abstract

“…Persistent back pain and radiculopathy are common symptoms. We are only aware of 11 previous reports [2][3][4][5][6][7][8][9][10][11][12] in the literature of Ewing sarcoma of the epidural space in a child (Table 1), and the majority of these are reported in boys (seven cases) and at the lumbar vertebral level or thoraco-lumbar junction (eight cases). Our report of a 5-year-old girl with an upper thoracic lesion will be the first of its kind with regard to age, sex, and site of occurrence.…”

Section: Discussionmentioning

confidence: 99%

Ewing sarcoma of the thoracic epidural space in a young child

et al. 2012

View full text Add to dashboard Cite

Purpose To report on the clinical course and treatment of Ewing sarcoma of the thoracic epidural space in a 5-yearold girl. Methods We present the case of a 5-year-old girl who experienced back pain (day 1); on day 10, the pain had exacerbated and involuntary movements in the lower limbs occurred, and an MRI performed in her local hospital revealed a tumor lesion at the upper thoracic level. Results On day 13, emergency surgery was performed for partial resection of the tumor. Pathological examination of the resected tumor by immunostaining and gene testing revealed that it was MIC2 positive and an EWS-FLI 1 chimera, respectively, and Ewing sarcoma was diagnosed. The involuntary movements resolved immediately after the surgery. Three weeks after the operation, chemotherapy and radiation therapy were commenced. After 5 months, deep tendon reflexes recovered to normal. MRI showed that the tumor has not recurred at 29 months after surgery. Conclusions The majority of epidural patients undergo emergency surgery only after symptom exacerbation, which includes the development of neurological deficits. Thus, preoperative diagnosis of Ewing sarcoma of the epidural space is difficult and diagnosis is frequently made by a post-operative gene test. The resection area is limited to the intralesional margin area because a larger resection is difficult due to the characteristics of the affected region; thus, there is a higher possibility of recurrence and careful follow-up of the case is necessary.

show abstract

Primary Ewing Sarcoma of Lumbar Spine With Massive Intraspinal Extension

Cited by 18 publications

References 12 publications

Dumbbell-shaped Ewing’s sarcoma family of tumor of thoracic spine in a child

Dumbbell-shaped Ewing’s sarcoma family of tumor of thoracic spine in a child

Primary Spinal Intradural Extraosseous Ewing Sarcoma in a Pediatric Patient: Case Report and Review of the Literature

Ewing sarcoma of the thoracic epidural space in a young child

Contact Info

Product

Resources

About