1962
DOI: 10.1016/0002-9343(62)90167-5
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Primary extragenital choriocarcinoma in the male subject

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Cited by 150 publications
(52 citation statements)
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“…8 Several theories explaining the pathogenesis of these extragonadal choriocarcinomas have been proposed. One hypothesis is that the tumors arise from the primordial germ cells that migrate abnormally during embryonic development; 37 another theory postulates development of these tumors secondary to dedifferentiation or neometaplasia of nongonadal tissue. 38 Still others, favor that extragonadal nongestational choriocarcinoma indeed represents a metastasis from a spontaneously regressed primary gonadal germ cell tumor.…”
Section: Discussionmentioning
confidence: 99%
“…8 Several theories explaining the pathogenesis of these extragonadal choriocarcinomas have been proposed. One hypothesis is that the tumors arise from the primordial germ cells that migrate abnormally during embryonic development; 37 another theory postulates development of these tumors secondary to dedifferentiation or neometaplasia of nongonadal tissue. 38 Still others, favor that extragonadal nongestational choriocarcinoma indeed represents a metastasis from a spontaneously regressed primary gonadal germ cell tumor.…”
Section: Discussionmentioning
confidence: 99%
“…Several histogenetic mechanisms have been proposed since the last of the twentieth century to explain extragonadal choriocarcinoma in men [6]. The remnant of germ-cell that failure migration has been postulated for embryologically related to the urogenital ridge (mediastinum, retroperitoneum, urinary bladder, and prostate or pelvic region) [7]. Mediastinal nongestational choriocarcinoma reported in nulligravid 22-year-old, the diagnosis was confirmed by histopathology of biopsy specimen and genotype of the tumor was strictly identical with the patient's genotype without any paternal features [8].…”
Section: Discussionmentioning
confidence: 99%
“…Urgently chemotherapy was started and the patient responded well to the standard protocol. Prognosis of PPC according to literature is worse than its testicular counterpart [5][6][7] but the present patient is doing relatively well possibly because the tumor is restricted to the lungs only. Cytomorphology of PCC parallels that of an undifferentiated highly malignant tumor.…”
Section: 25-7mentioning
confidence: 94%
“…2,5,6 Often the entity is misdiagnosed as more common diseases such as primary or secondary lung tumors, tuberculosis, pneumonia or lymphoma and thus potentially curative chemotherapy or surgery may be delayed. [5][6][7] Considering its rarity, prognosis and diagnostic difficulties FNAC definitely has a role in such cases! A 26 year-old non-smoker male with no significant medical or surgical history presented with the complaints of progressive shortness of breath, productive cough, night sweats, diminished appetite and unexplained weight loss for 4 weeks.…”
Section: 4mentioning
confidence: 99%