Primary Extramedullary Plasmacytoma of the Lung.

Nonomura, Akitaka; Mizukami, Yuji; Shimizu, Junji; Oda, Makoto; Watanabe, Yoh; Kamimura, Ryotaro; Takashima, Tsutomu; Kitagawa, Masanobu

doi:10.2169/internalmedicine.31.1396

Cited by 28 publications

(12 citation statements)

References 13 publications

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“…Mutations in several genes necessary for cytokinesis in Dictyostelium also result in multinucleate cells, although these cells can have up to 50 nuclei per cell (Adachi, 2001). It is interesting that several different human tumor types have multinucleate cells (Jayaram and Abdul Rahman, 1997;Long and Aisenberg, 1975;Nonomura et al, 1995;Ramos et al, 2002). AprA thus effectively has two functions: the first to slow the cell cycle and the second to coordinate cytokinesis with mitosis.…”

Section: Discussionmentioning

confidence: 99%

A secreted factor represses cell proliferation inDictyostelium

2005

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Many cells appear to secrete factors called chalones that limit their proliferation, but in most cases the factors have not been identified. We found that growing Dictyostelium cells secrete a 60 kDa protein called AprA for autocrine proliferation repressor. AprA has similarity to putative bacterial proteins of unknown function. Compared with wild-type cells, aprA-null cells proliferate faster, while AprA overexpressing cells proliferate slower. Growing wild-type cells secrete a factor that inhibits the proliferation of wild-type and aprA- cells;this activity is not secreted by aprA- cells. AprA purified by immunoprecipitation also slows the proliferation of wild-type and aprA- cells. Compared with wild type, there is a higher percentage of multinucleate cells in the aprA- population,and when starved, aprA- cells form abnormal structures that contain fewer spores. AprA may thus decrease the number of multinucleate cells and increase spore production. Together, the data suggest that AprA functions as part of a Dictyostelium chalone.

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Section: Discussionmentioning

confidence: 99%

A secreted factor represses cell proliferation inDictyostelium

2005

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“…A variety of other sites can rarely be involved, including testis, bladder, urethra, breast, ovary, lung, pleura, thyroid, orbit, brain, skin, adrenal glands, retroperitoneum, central nervous system, spleen and the lymph nodes (Cavanna et al, 1990;Rubin et al, 1990;Matsumiyama et al, 1992;Nonamura et al, 1992;Wong et al, 1994;Adkins et al, 1996;Fischer et al, 1996;Tuting & Bork, 1996 A monoclonal paraprotein is detected in the serum and/or urine in fewer than 25% of patients (Table 1). Local recurrence rates of <5% have been quoted after radiotherapy .…”

Section: Epidemiology and Clinically-laboratory Featuresmentioning

confidence: 99%

Solitary Bone and Extramedullary Plasmacytoma

Salogub¹,

Lokhmatova²,

Sozin³

2012

Multiple Myeloma - An Overview

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“…Six reported patterns of EMP (extramedullary plasmacytoma) of the thorax include lung mass [3], multiple pulmonary nodules [4], diffuse reticulonodular infiltration by myeloma cells with amyloid deposition [2], lymphadenopathy and mediastinal mass [4,5] pleural effusion with nodular pleural thickening [4] and tracheobronchial infiltration [2].…”

Section: Introductionmentioning

confidence: 99%