Primary Extramedullary Plasmacytoma of the Penis: A Case Report

Abstract

Extramedullary plasmacytoma involving the penis is extremely rare. Here, we describe a case of primary extramedullary plasmacytoma of the penis in a 64-year-old man who presented with a palpable penile mass. Nuclear magnetic resonance imaging revealed the presence of a large, round non-encapsulated mass in the perineum. A contrast-enhanced computed tomography scan of the pelvis showed that the mass was located in the tunica albuginea and corpora cavernosa at the base of the penis. The mass encased the urethra and demonstrated no marked enhancement during the arterial phase. The patient underwent successful surgical resection of the tumor. Histologically, the tumor was composed primarily of neoplastic plasma cells that were positive for CD38, vimentin and Ki 67. Postoperatively, the patient recovered well and exhibited no evidence of development of multiple myeloma, local recurrence or distant metastasis at 2 months post-surgery. To the best of our knowledge, our case represents the first documented case of human primary extramedullary plasmacytoma of the penis.

Extramedullary Plasmacytoma of the Penis as a First Manifestation of Multiple Myeloma: A Case Report

“…Approximately 80-90% of EMPs arise in the upper respiratory and digestive tracts [4]. Patients usually present with localized submucosal masses and accompanying symptoms related to compression and obstruction of local structures between the fifth and seventh decades of life [1].…”

“…A solitary plasmacytoma is an exquisitely rare tumor of the penis, and there have been only two reported cases of EMP involving the penis [1, 3]. The etiology of EMP is poorly understood, although the possible factors are chronic infection, chronic stimulation by irritants, and a history of chronic inflammation [1]. EMP localizes to soft tissues and can develop in any part of the body but occurs most frequently in the head and neck regions.…”

“…EMPs are highly sensitive to radiotherapy, and thus local disease control and long-term disease-free survival can be achieved with radiotherapy alone [1]; however, our patient due to the multiple areas of bone rarefaction, which are sufficient for diagnosing multiple myeloma, has been qualified for first-line chemotherapy treatment. Typically, patients are treated with approximately 3–4 cycles of induction therapy with bortezomib, lenalidomide, and dexamethasone (VRd) prior to stem cell harvest [5].…”

“…Plasmacytoma is an uncommon plasma-cell neoplasm that can be categorized into two groups depending on its location. These groups consist of solitary plasmacytoma of the bone and extramedullary plasmacytoma (EMP), where tumor cells develop in tissues outside the bone [1]. Around 85% of lesions primarily develop in the head and neck mucosa.…”

Erythematous Papule on the Glans Penis

“…Penile plasmacytoma is an extremely rare entity and scarcely reported in the literature. To date, only 3 cases have been reported: 2 extramedullary cutaneous plasmacytomas involving the penis, and 1 case of a primary extramedullary plasmacytoma of the penis …”