Primary extranodal histiocytic sarcoma of lumbar spine

Abstract

A 17-year-old male patient presented with lower back pain and weakness of lower limbs. On radiological investigation, a destructive bony lesion involving the third lumbar vertebra was seen associated with soft tissue extension and an extradural component. The lesion was surgically excised in view of the rapidly progressing symptoms. The histologic diagnosis was histiocytic sarcoma. Further investigations did not reveal any other lesion elsewhere. The case is being presented in view of the uncommon occurrence of a primary extranodal histiocytic sarcoma of the lumbar spine, which simulated a primary bone tumor.

Morphological Distinction of Histiocytic Sarcoma from Other Tumor Types in Bernese Mountain Dogs and Flatcoated Retrievers

“…The characteristic kidney-shaped nuclei have also been reported before in canine HS (33,39,46) and in human HS (47) and IDCS (14). Indentations of the nucleus have been reported in the canine literature (1,7,24,26,28) as well as in human HS (41) and IDCS (48), and a combination of indentations, grooves or folds in human HS (43,49), IDCS (14) and LCH (50). This indicates that a canine subtype comparable to human LCH/LCS may also exist.…”

“…This has been reported before in canine HS (1,6,7,28,(33)(34)(35)(36)(37)(38)(39) and is also often seen in human HS, sometimes simultaneously with spindle cells (40,41). In addition, extramedullary hematopoiesis was seen more often in BMD than in FCR.…”

“…This indicates that a canine subtype comparable to human LCH/LCS may also exist. An eccentrically located nucleus was reported in canine HS (6,37,51) and in human HS (41) and IDCS (14). Further research will shed light on possible similarities among human and canine histiocytic tumor subtypes.…”

A rare case of primary extranodal, extradural histiocytic sarcoma of the thoracic spine and review of literature

“…However its primary occurrence in spine causing its compression is very rare and few cases were reported in the literature very recently. [134] It is a highly malignant neoplasm showing frequent areas of atypia, mitotic figures, nuclearpleomorphism. Corresponding to its aggressive behavior it usually has a short duration of symptoms as shown in the present case.…”

“…There was only one such presentation of isolated extradural primary histiocytic sarcoma of spine in the literature. [1]…”