Primary extranodal natural killer/T-cell nasal-type lymphoma of spine

Abstract

Rationale: Primary Extranodal Natural Killer/T-Cell Nasal-Type Lymphoma (ENKTCL) of spine is rarely reported. This case study presents a rare case of ENKTCL originating from the sixth thoracic vertebra.Patient concerns: Here, we present a case of 49-year-old Asian male with chest and back pain. Physical examination revealed the myodynamia of both lower limbs decreased from IV degree to 0 degree, reflexes of both lower limbs and a large area of cutaneous sensation below xiphoid process disappeared in 3 days.Diagnoses: In immunophenotype analysis, CD2, CD3, CD7, and CD68 were positive and CD56 was suspiciously positive. Granzyme B and T-cell intracellular antigen (TIA-1) were also positive and in situ hybridization was positive for Epstein-Barr virusencoded mRNA (EBER). Ki-67 was 60%+. Nuclide bone scan showed that the nuclide was unusually concentrated in the sixth thoracic vertebra which considered extremely active and slightly concentrated in the right sacrolilac joint. Magnetic resonance imaging detected an abnormal signal in the sixth thoracic vertebra with corresponding paravertebral and intraspinal occupying lesion. Based on the above features, a diagnosis of ENKTCL was made.Interventions: This patient was treated with surgery and symptomatic supportive treatment.Outcomes: The myodynamia of patient's both lower limbs were elevated to I degree after the operation with chest and back pain partly relieved. However, the patient died about 3 months later.Lessons: ENKTCL could originate from spine. Clinicians should be alert for early stage diagnose and distinguish it from some common spinal tumor such as neurofibroma and hemangioma. Abbreviations: CT = computed tomography, EBER = Epstein-Barr virus-encoded mRNA, ENKTCL = extranodal NK/T-cell lymphoma, nasal type, OS = overall survival, PET-CT = positron emission tomography, PFS = progression-free survival, TCR = T-cell receptor, TIA-1 = T-cell intracellular antigen.

Therapeutic mechanism of 32-P application combined with timolol maleate for infantile superficial hemangioma

“…This result is consistent with the studies of Wang et al, which all confirmed that 32 P application combined with thiomolol maleate significantly improved the cure rate and therapeutic effect in children with cutaneous hemangioma. In other words, as a kind of external irradiation, a certain dose of radionuclide is close to the lesion site, and the biological effect of ionizing radiation on the lesion site through radiation can reduce the rate of cell division, prolong the interval of nuclear division and occlusion of microvessels, so as to achieve the therapeutic purpose (22,23) .…”

Primary spinal extranodal NK/T‐cell lymphoma diagnosed by fine‐needle aspiration and core biopsy

“…In search of the literature, we identified three cases of PSENKTL 7–9 . Table 1 summarized the clinicopathological features of the three cases and ours.…”

“…In search of the literature, we identified three cases of PSENKTL. [7][8][9] Table 1 summarized the clinicopathological features of the three cases and ours. The median age at presentations was 49 years old with a male predominance (M:F = 3:1).…”

“…In up to 11% of ENKTL cases, patients could present with hemophagocytic lymphohistiocytosis (HLH) 4 . Primary spinal ENKTL (PSENKTL) was extremely rare with only three cases being reported in the literature 7–9 . Here, we reported one such case which was diagnosed by fine‐needle aspiration and core biopsy (FNACB).…”

“…4 Primary spinal ENKTL (PSENKTL) was extremely rare with only three cases being reported in the literature. [7][8][9] Here, we reported one such case which was diagnosed by fine-needle aspiration and core biopsy (FNACB). This case raised awareness of ENKTL as a differential diagnosis in patients with spinal lesions.…”