Primary Extranodal Non-Hodgkin’s Lymphoma of the Head and Neck

Economopoulos, Theofanis; Asprou, N; Stathakis, N.; Fountzilas, George; Pavlidis, N.; Papaspyrou, Spyros; Dervenoulas, John; Belia, Marina; Papageorgiou, Efstathios; Theoharis, Dimitrios

doi:10.1159/000227097

Cited by 48 publications

(45 citation statements)

References 5 publications

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“…Among patients of DLBL subgroup, 2-year PFS and OS according to different chemotherapy regimens were MCP-842 with 51% and 69.2%, CHOP: 65% and 80%, R-CHOP: 83.3%, and 88.7% (23). Another study (14) showed that 5-year OS rate was 65% for patients. Two studies in our area showed the 3-year, 5-year and 10-year OS rates for nodal NHL patients were 65%, 54.2% and 51%, respectively (24) and for extranodal were 70%, 62.2% and 60.8%, respectively (25).…”

Section: Discussionmentioning

confidence: 96%

“…2017; 10(1):e5226. (14), among 387 NHL patients, the median age was 55 years with a male to female (M: F) ratio of 1.9:1. Naz et al (15) reported that in NHL patients, 67% were male and M: F ratio was 2.6:1 with the mean age of 43.9 years (range, 6 to 80 years).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the prevalence of nodal is more than extranodal. A study (14) showed that in their patients with NHL, the aggressive histological subtypes predominate. Our study confirmed this result.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathology Figures and Survival of Non-Hodgkin’s Lymphoma in Iran

2017

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Background: Non-Hodgkin's lymphoma (NHL) is the fifth most frequently diagnosed cancer whose incidence has risen by at least 100 percent over the past five decades especially in the West. Objectives: The aim of this study is to investigate Clinicopathology figures, overall survival (OS) and Progression-free survival (PFS) in patients with NHL in Iran. Methods: In a descriptive study, 143 patients referred to Clinic of Hematology in two centers between 2005 and 2014. We checked age, sex, types and subtypes of NHL; recurrence, Ki-67, organomegaly, lymphadenopathy, radiotherapy, OS and PFS in the patients. The mean follow-up was 49 months. All patients received R-CHOP regimen for 6 to 8 cycles. Results:The mean age at diagnosis for the patients was 46 years (range, 16 -82) and 76.9% had age < 60 years and 62.2% were male. 58% patients had primary nodal NHL and out of 139 patients, 88.5% were aggressive NHL. Organomegaly and lymphadenopathy were in 12 patients (8.4%) and 80 (55.9%), respectively. Of all patients, 106 patients (74.1%) were treated with radiotherapy. 2-year OS rate was 91.5% and 5-year OS rate was 85%.2-and 5-year PFS rates were 79.6% and 63.3%, respectively. Conclusions: Percentage of NHL in males is more than females and the median age is around 45 years. Also, the prevalence of nodal is more compared with extranodal in NHL patients.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Clinicopathology Figures and Survival of Non-Hodgkin’s Lymphoma in Iran

2017

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“…This tropism for specific sites has been particularly noticeable for the tonsils and stomach [17,18], testis and nasopharynx, and skin and bone [16,19].…”

Section: Discussionmentioning

confidence: 99%

Multifocal Extranodal Non-Hodgkin Lymphoma: A Clinicopathologic Study of 37 Cases in Greece, a Hellenic Cooperative Oncology Group Study

et al. 2005

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The purpose of this retrospective study was to illustrate the clinicopathological features of patients presenting with multifocal extranodal non-Hodgkin lymphoma (NHL). Among 810 patients with NHL, 37 cases (4.2%) were found to have multiple extranodal involvement (two or more sites). There were 24 men and 13 women, with a median age of 63 years. The majority of these cases (n = 26) had gastric or intestinal (GI) involvement with or without other extranodal sites. Lung along with another extranodal site was relatively common in the present series. Stratification of the 37 cases according to the International Prognostic Index (IPI) showed that 89% of the patients belonged to the high-risk groups. Diffuse large-B-cell lymphoma (DLBCL) accounted for 62%, and mucosa-associated lymphoma tissue (MALT) lymphoma accounted for 27% of all cases. After induction treatment with anthracycline-based regimens, complete remission was achieved in 21 patients (57%), partial remission was achieved in six patients (16%), and seven patients (19%) had no response, while three patients (8%) were nonevaluable. In conclusion, multifocal extranodal NHL is a heterogeneous group of diseases. The majority of them arise at various sites in the GI tract. DLBCL was the most frequent histological subtype followed by MALT lymphoma. Risk group, as defined by the IPI, was predictive of survival. The Oncologist 2005;10:734-738

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“…The reason for multifocal extranodal lymphomas or the preferential involvement of specific extranodal sites at recurrence remains to be investigated, but it is likely that this is closely associated with the homing process that's regulated by homing receptors, or by the lymphoid cells and ligands on the endothelial venules (10). This tropism for specific sites has been particularly noted in the tonsils and stomach, testes (11,12), and nasopharynx, in addition to the skin and bones (10,13).…”

Section: Discussionmentioning

confidence: 99%

Unusual Presentation of Large B Cell Lymphoma- Bone and Stomach- Treated with Autologous Transplantation

Lee

Kwon

et al. 2007

Cancer Res Treat

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Extranodal presentation of diffuse large B cell lymphoma (DLBL) is frequently observed in the gastrointestinal tract, CNS, bone, testes and liver. However, the simultaneous detection of multiple extranodal involvement at presentation is quite an uncommon occurrence. In this study, we report on a patient with an uncommon presentation of DLBL, and he had symptoms of left knee joint pain and hematemesis, characterized by bone and stomach in-

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Primary Extranodal Non-Hodgkin’s Lymphoma of the Head and Neck

Cited by 48 publications

References 5 publications

Clinicopathology Figures and Survival of Non-Hodgkin’s Lymphoma in Iran

Clinicopathology Figures and Survival of Non-Hodgkin’s Lymphoma in Iran

Multifocal Extranodal Non-Hodgkin Lymphoma: A Clinicopathologic Study of 37 Cases in Greece, a Hellenic Cooperative Oncology Group Study

Unusual Presentation of Large B Cell Lymphoma- Bone and Stomach- Treated with Autologous Transplantation

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