Primary extraosseous osteosarcoma of the lung

Karfis, Elias; Karaiskos, Theodoros; Cheva, Angeliki; Drossos, Georgios

doi:10.1080/02841860902953864

Cited by 3 publications

(11 citation statements)

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“…The median age of the 60 patients was 60 years (range, 14-93 years). A majority of the cases involved males (65%, 39/60 cases), which is similar to previously reported case series (30). The tumors were usually large with a median size of 8.2 cm (range, 2.5-30 cm).…”

Section: Epidemiology and Clinical Characteristicssupporting

confidence: 72%

Primary thoracic extraskeletal osteosarcoma: a case report and literature review

Qian

Zhang

et al. 2017

J. Thorac. Dis.

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Primary extraskeletal osteosarcoma (ESOS) presenting in thoracic locations is very rare and associated with a poor prognosis. The current study presents a case involving a large anterior mediastinal mass, which was histologically confirmed as a primary osteosarcoma. The literature concerning primary thoracic ESOS is reviewed. A total of 60 cases were identified. The median age was 60 years (range, 14-93 years) and males were more prevalent among the reported cases (65%). Survival analysis revealed that the overall 5-year survival was only 22.3%. The majority of cases of thoracic ESOS presented in the lung (n=24, 40%), with others presenting in the mediastinum, pleura, or chest wall. The benefit of surgery, chemotherapy and radiotherapy was confirmed by Cox regression survival analyses.

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Section: Epidemiology and Clinical Characteristicssupporting

confidence: 72%

Primary thoracic extraskeletal osteosarcoma: a case report and literature review

Qian

Zhang

et al. 2017

J. Thorac. Dis.

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“…1,3,4,21 Primary osteosarcomas of parenchymal organs are very rare, but cases arising with the thyroid, kidney, gallbladder, breast, mesentery, uterus, brain, lung, bladder, heart, and colon have been reported. [22][23][24][25][26][27][28][29][30][31][32] Primary osteosarcoma of the liver is an exceedingly rare hepatic tumor. A literature search yielded 11 case reports of primary hepatic osteosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Primary Hepatic Osteosarcoma: A Rare Cause of Primary Liver Tumor

Tamang

Shuster

Chandra

2016

Clin Med Insights Case Rep

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IntRoduCtIon: Extraosseous osteosarcomas are rare, accounting for approximately 4% of all osteosarcomas. A literature review yields very few cases of osteosarcoma primarily arising from the hepatic parenchyma. CAse RepoRt: This report describes a case of a man in his 50s with a history of hepatitis C and cirrhosis who presented with 5 days of progressive right upper quadrant pain. Magnetic resonance imaging of the abdomen and pelvis demonstrated a 4.4 cm × 4.8 cm × 4.8 cm right hepatic lobe mass with a large area of necrosis and peripheral enhancement. The subsequent liver biopsy showed few cores of tumor composed of fibroblastic malignant cells producing lace-like osteoid matrix. Osteosarcomatous foci in other parts of the body were excluded by performing extensive physical examination, radiologic imaging, and biopsy. Hence, a primary osteosarcoma was diagnosed. The patient underwent portal vein embolization in preparation for a surgical resection of the right liver lobe. He was admitted six weeks after the embolization for dyspnea and abdominal distension and expired due to abdominal hematoma and pulmonary embolism. ConClusIon: Based on the rarity, lack of consensus in treatment, and dismal prognosis, extraosseous osteosarcoma should be considered a separate entity from osseous osteosarcoma. More data and research are needed in this rare and understudied malignancy.

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Section: Introductionmentioning

confidence: 99%

“…Primary pulmonary osteosarcoma (PPOS) is a rare neoplasm accounting for only 0.01% of malignancies that originated primarily from the lung [1,2]. In contrast to osteosarcoma originating from the skeletal system and is common in young patients, PPOS tended to suffer among the patients over 50 years [2][3][4][5] and was characterized with osteoid formation [6,7]. To our knowledge, PPOS was first reported by Edward in 1933 [8], and patients with PPOS were found to have a poor prognosis, with a median overall survival (OS) of 10.0 months [4].…”

Section: Introductionmentioning

confidence: 99%

“…In most cases, the tumor might grow to large size of over 5 cm before diagnosis, and PPOS would have a rapid progression after diagnosis [5,[9][10][11]. The preferred management for PPOS remains controversial, while extensive and radical surgical resection might lead to favored survival [2,5,12]. Therefore, the role of radiotherapy or chemotherapy has not been well studied among patients with PPOS [5,13].…”

Section: Introductionmentioning

confidence: 99%

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Characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis

Huang

Deng

et al. 2022

J Cardiothorac Surg

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Background Primary pulmonary osteosarcoma (PPOS) is an uncommon malignancy originating from the lung with low incidence, and its clinical characteristics and prognosis have not been systematically reported. Therefore, we aimed to recognize the prognostic factors and constructed a survival prediction model for PPOS. Methods We collected the data from the Surveillance, Epidemiology, and End Results database and systematic review of previous studies. Demographical and clinical characteristics, radiographic manifestations, treatment modalities, and prognosis were analyzed. A prediction model via nomogram was constructed and then evaluated by the concordance index (C-index) and the receiver operating characteristic (ROC) curve. Results A total of 49 cases were included for analysis with a median age of 67 years old (range 33–94 years), of which 32 (65.3%) were male. The median size was 6 cm (range 1.8-25 cm), and the median overall survival (OS) was eight months (interquartile range 4.5–12 months) with a 1-year OS rate of 30.8%. Tumor size over 7 cm (hazard ratio [HR] = 2.98; P = 0.018) and those without microscopic findings of osteoid found in the tumors (HR = 2.11; P = 0.048) were referred to a poor OS, while surgery was associated with an improved OS (HR = 0.20; P < 0.001). The C-index of the nomogram prediction model was 0.771, and the area under curve, sensitivity and specificity of the ROC curve were 0.818, 0.848 and 0.800, respectively. Conclusions Patients with PPOS had a poor prognosis, and tumor size was mostly prognostic. Surgery seemed to be an effective treatment, and the prediction model with a nomogram in our study could effectively predict the prognosis of patients with PPOS.

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Primary extraosseous osteosarcoma of the lung

Cited by 3 publications

References 0 publications

Primary thoracic extraskeletal osteosarcoma: a case report and literature review

Primary thoracic extraskeletal osteosarcoma: a case report and literature review

Primary Hepatic Osteosarcoma: A Rare Cause of Primary Liver Tumor

Characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis

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