Primary fallopian tube carcinoma

Mladenović-Segedi, Ljiljana

doi:10.2298/mpns0902031m

Cited by 10 publications

(10 citation statements)

References 41 publications

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“…Up to 40%-60% of high-grade serous carcinomas of the ovary or peritoneum may have fallopian tube fimbriae origin as per genetic, molecular, and histologic evidence [ 12 ]. Chronic tubal inflammation, infertility, tuberculous salpingitis, and tubal endometriosis can be associated with PFTC, but the exact etiology is still unknown, though it is associated with BRCA germline and TP53 mutations (similarly to ovarian carcinoma) [ 13 - 15 ].…”

Section: Discussionmentioning

confidence: 99%

Fallopian Tube Tumor Mimicking Primary Gastrointestinal Malignancy

Gupta

Vazquez

2020

Cureus

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A 67-year-old female patient positive for a mismatch repair gene mutation and history of serous carcinoma of the fallopian tube presented with a lower gastrointestinal bleed. Clinical workup was suggestive of a primary gastrointestinal malignancy. Pathological review after right hemicolectomy revealed the primary tumor was a fallopian tube carcinoma. Over the next few years, she presented with upper and lower gastrointestinal bleeds from a recurrent metastatic disease, which was from the primary fallopian tube cancer. Although serous carcinoma of the fallopian tube is not an uncommon diagnosis, it is unusual for it to present with symptoms of recurrent gastrointestinal bleed mimicking a primary gastrointestinal malignancy.

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Section: Discussionmentioning

confidence: 99%

Fallopian Tube Tumor Mimicking Primary Gastrointestinal Malignancy

Gupta

Vazquez

2020

Cureus

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“…Therefore the incidence of fallopian tube cancers may have been underestimated [ 9 ]. The aetiology of this tumour is unknown enough; it is suggested to be associated with chronic tubal inflammation, infertility, tuberculous salpingitis and tubal endometriosis [ 10 ]. Similar to ovarian malignancy, a BRCA germline mutation and TP53 mutation are associated with fallopian tube malignancy [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Primary Fallopian Tube Carcinoma: A Case Report and Literature Review

Rexhepi¹,

Trajkovska²,

Ismaili³

et al. 2017

Open Access Maced J Med Sci

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BACKGROUND:Primary fallopian tube carcinoma (PFTC) is a rare tumour of the female genital tract with an incidence of 0.1-1.8% of all genital malignancies, and it is very difficult to diagnose preoperatively, because of its non-specific symptomatology. In most cases, it is an intraoperative finding or a histopathological diagnosis. It is a tumour that histologically and clinically resembles epithelial ovarian cancer.CASE PRESENTATION:We are reporting a case of a 62-year-old, postmenopausal women with primary fallopian tube carcinoma of the right fallopian tube in stage IA. The patient has lower abdominal pain, watery vaginal discharge and repeated episodes of bleeding from the vagina. The clinical and radiological findings suggested a right adnexal tumour with elevated CA-125 levels. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy and peritoneal washing were performed. Pathologic confirmation of primary serous cystadenocarcinoma of the right fallopian tube was made. Peritoneal washings were negative for malignancy. FIGO stage was considered as IA, and the patient received no courses of chemotherapy and postoperative radiation because she refused it. Ten months after initial surgery, the patient is alive and in good condition.CONCLUSION:Cytoreduction surgery followed by adequate cycles of chemotherapy is an important strategy to improve patients’ prognosis.

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“…The etiology of this tumor is still unknown, and because such cancer types tend to be diagnosed at advanced stages, the early molecular events underlying development are not fully clarified. A series of studies may attribute such cases to chronic tubal inflammation, infertility, tuberculosis salpingitis or tubal endometriosis [23]. Meanwhile, germline BRCA1 and BRCA2 mutations, as in ovarian and breast cancer, showed an increased tendency to lead to PFTC development [24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Anterior mediastinal metastasis of primary fallopian tube adenocarcinoma: a case report

Zhang

Liu

et al. 2020

J Cardiothorac Surg

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Background: Primary fallopian tube carcinoma (PFTC) is a malignant tumor of the female genital tract that mostly presents intraperitoneal dissemination in clinical practice. The incidence of upper anterior mediastinal metastasis in PFTCs is extremely rare. We herein report a rare case of PFTC mediastinal metastasis after radical resection. When anterior mediastinal metastasis of an unknown origin is encountered, the possibility of PFTC should be considered. Case presentation: A 68-year-old female who was previously diagnosed with PFTC after radical resection of a primary tumor in the fallopian tube was admitted to our department with a right anterior mediastinum mass. Radical resection of the mediastinal mass was performed, and poorly differentiated metastatic adenocarcinoma of the fallopian tube was confirmed. There was no recurrence in the 24 months after the curative operation. Conclusion: To our knowledge, no mediastinal metastasis of PFTC has been reported yet. Thus, we presented this rare case indicating the heterogeneity of this malignant disease and to draw attention to the occasional distant metastasis of PFTC in clinical practice.

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Primary fallopian tube carcinoma

Abstract: The treatment approach is similar to that of ovarian carcinoma, and includes total abdominal hysterectomy and bilateral salpingo-oophorectomy. Staging is followed with chemotherapy.

Cited by 10 publications

References 41 publications

Fallopian Tube Tumor Mimicking Primary Gastrointestinal Malignancy

Fallopian Tube Tumor Mimicking Primary Gastrointestinal Malignancy

Primary Fallopian Tube Carcinoma: A Case Report and Literature Review

Anterior mediastinal metastasis of primary fallopian tube adenocarcinoma: a case report

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