Primary fibrosarcoma of the ovary

Stellato, G; Bonito, Maurizio Di; Tramontana, S.

doi:10.3109/00016349509013482

Cited by 13 publications

(7 citation statements)

References 13 publications

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“…The role of pelvic irradiation or chemotherapy in improving survival remains to be determined, and most of the reported cases died or developed recurrence within 2 years, even those with early stage disease (2,4) . Recently, combination chemotherapy with MAID (mesna, doxorubicin ifosfamide, and DTIC) (3,9,10) has shown efficacy against ovarian and extremities sarcoma. In this case, adjuvant chemo-therapy with MAID regimen was performed after surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Primary ovarian fibrosarcoma is exceedingly rare. To date, only about 20 cases have been reported in the literature (2)(3)(4)(5) , and most of the patients died or succumbed to recurrence within 2 years even those with early stage disease. Here we present a patient with fibrosarcoma of the ovary who is free from disease 70 months after surgery followed by adjuvant combination chemotherapy.…”

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confidence: 99%

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Ovarian fibrosarcoma with long-term survival: A case report

Huang

Hsu

Chou

et al. 2001

Int J Gynecol Cancer

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Abstract.Huang Y-C, Hsu K-F, Chou C-Y, Dai Y-C, Tzeng C-C. Ovarian fibrosarcoma with long-term survival.Primary ovarian fibrosarcoma is an exceedingly rare malignant ovarian stromal tumor which has a poor prognosis. We report here a 46-year-old woman who suffered from irregular vaginal bleeding for 2 months. She received hysterectomy and salpingo-oophorectomy due to a provisional diagnosis of uterine and ovarian tumors. At surgery, an 8-cm ovarian solid multilobular tumor was found. Frozen section examination revealed an ovarian fibrosarcoma. She then underwent staging procedures including intraperitoneal washing, cytology, and pelvic and para-aortic lymph node sampling. Final pathologic examination revealed that the tumor exhibited densely packed spindle cells in storiform configuration with obvious increased mitotic activity. In addition, the flow cytometric study showed marked elevated percentage of tumor cells in the S phase (13.1%). After surgery, the patient received six courses of combination chemotherapy with epirubicin, ifosfamide, and dacarbazine (DTIC). The patient stood the treatment well and is free from disease 6 years later.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Ovarian fibrosarcoma with long-term survival: A case report

Huang

Hsu

Chou

et al. 2001

Int J Gynecol Cancer

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“…Fibrosarcoma is a rare entity in the ovary; less than one hundred cases have been reported so far. Isolated cases of unilateral primary fibrosarcoma of the ovary[12] and a rare case of bilateral ovarian fibrosarcoma have been reported. [3] It has also been reported in association with the basal cell nevus syndrome[4] and Maffucci syndrome.…”

Section: Introductionmentioning

confidence: 99%

Giant primary ovarian fibrosarcoma: Case report and review of pitfalls

Ray

Biswas

Mukhopadhyay

2012

J Cytol

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Primary ovarian fibrosarcomas are very uncommon neoplasms; less than one hundred cases have been reported. Diagnosis can be difficult to establish and other similar appearing mesenchymal lesions must be ruled out. A 23 year old nulliparous woman presented with a huge right ovarian tumor (25 × 17 × 12 cm). Ultrasonography guided aspiration was performed and a strong possibility of fibrosarcoma was suggested based on cytomorphological findings. No epithelial element was noted. She underwent surgical excision which confirmed the diagnosis of primary ovarian fibrosarcoma (the largest till date to our knowledge). Immunohistochemical analyses showed vimentin and CD 34 positivity. We speculate that ovarian fibrosarcoma at the preoperative examination might be considered in the differential diagnosis whenever a unilateral, heterogeneous, largely round solid ovarian lesion is detected.

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“…[7]reportedthepossibilityofprolongedsurvivalbyacombinedchemotherapy(MAID:mesna, doxorubicin, ifosfamide and dimethyl trizeno-imidazole carboxamide (DTIC)). This has also been described for other ovarian sarcomas and sarcomas of the extremities [15][16][17]. Celýketal.…”

Section: Discussionmentioning

confidence: 98%

Rectal Intussusception due to Re-Recurrent Ovarian Fibrosarcoma

Langner¹,

Glitsch²,

Krüger³

et al. 2009

Onkologie

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Background: Primary ovarian fibrosarcomas are very rare tumours associated with an extremely poor prognosis. Most patients relapse or die within 2 years. Because of the low incidence, it is difficult to identify prognostic factors or to establish treatment guidelines. Case Report: In this report, we present a patient with the second relapse of an ovarian fibrosarcoma localised in the rectosigmoid. The tumour caused intussusception into the rectum, leading to large bowel obstruction. After complete resection of the tumour, the patient completely recovered. 28 months after primary diagnosis, follow-up did not show any signs of recurrent tumour disease. Conclusions: Reviewing the literature, it is recommended that all patients should primarily be operated on and generally be followed up closely. In patients with incomplete resection, palliative chemo- and/or radiotherapy is recommended. In our opinion, in patients with complete resection, adjuvant chemo- and/or radiotherapy should be considered. Only in patients with high-grade fibrosarcomas, adjuvant intra- or postoperative radiotherapy should be applied.

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Primary fibrosarcoma of the ovary

Cited by 13 publications

References 13 publications

Ovarian fibrosarcoma with long-term survival: A case report

Ovarian fibrosarcoma with long-term survival: A case report

Giant primary ovarian fibrosarcoma: Case report and review of pitfalls

Rectal Intussusception due to Re-Recurrent Ovarian Fibrosarcoma

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