Primary Fluorescence of Normal and Pathologic Keratin**From the Medical Service, Section of Dermatology, Veterans Administration Hospital, Brooklyn, New York, and the Department of Medicine, Division of Dermatology and Syphilology, State University of New York, Downstate Medical Center at New York City.This study was supported by a grant from the National Institutes of Health, U. S. Public Health Service, Grant RG-4961.

Steiner, Karl

doi:10.1038/jid.1962.64

Cited by 15 publications

(9 citation statements)

References 8 publications

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“…Until recently, VIS (400–700 nm) has been regarded to have no significant cutaneous photobiologic effects. This was not entirely true, as an early study from Pathak et al [ 18 ]. Pathak in 1962, reported that exposure to VIS results in immediate pigment-darkening (IPD) [ 18 ].…”

Section: Solar Radiation and Deleterious Cutaneous Effectsmentioning

confidence: 99%

“…This was not entirely true, as an early study from Pathak et al [ 18 ]. Pathak in 1962, reported that exposure to VIS results in immediate pigment-darkening (IPD) [ 18 ]. In 1984, Kollias and Baqer [ 19 ] performed an in vivo study to observe the pigmentary induced by VIS and NIR light.…”

Section: Solar Radiation and Deleterious Cutaneous Effectsmentioning

confidence: 99%

“…The VIS part of the spectrum has not been as thoroughly investigated as the UV radiation subset [ 16 , 17 ]. VIS induces transient [ 18 ] as well as long lasting pigmentation in humans [ 19 ]. However, limited information is available regarding the side effect of VIS.…”

Section: Solar Radiation and Deleterious Cutaneous Effectsmentioning

confidence: 99%

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Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review

Parrado

Mascaraque

Gilaberte

et al. 2016

IJMS

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Healthier life styles include increased outdoors time practicing sports and walking. This means increased exposure to the sun, leading to higher risk of sunburn, photoaging and skin cancer. In addition to topical barrier products, oral supplementations of various botanicals endowed with antioxidant activity are emerging as novel method of photoprotection. Polypodium leucotomos extract (PL, commercial name Fernblock®, IFC Group, Spain) is a powerful antioxidant due to its high content of phenolic compounds. PL is administered orally, with proven safety, and it can also be used topically. Its mechanisms include inhibition of the generation and release of reactive oxygen species (ROS) by ultraviolet (UV) light. It also prevents UV- and ROS-induced DNA damage with inhibition of AP1 and NF-κB and protection of natural antioxidant enzyme systems. At the cellular level, PL decreases cellular apoptosis and necrosis mediated UV and inhibits abnormal extracellular matrix remodeling. PL reduces inflammation, prevents immunosuppression, activates tumor suppressor p53 and inhibits UV-induced cyclooxygenase-2 (COX-2) enzyme expression. In agreement with increased p53 activity, PL decreased UV radiation-induced cell proliferation. PL also prevents common deletions mitochondrial DNA damage induced by UVA, and MMP-1 expression induced Visible Light and Infrared Radiation. These cellular and molecular effects are reflected in inhibitions of carcinogenesis and photoaging.

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Section: Solar Radiation and Deleterious Cutaneous Effectsmentioning

confidence: 99%

Section: Solar Radiation and Deleterious Cutaneous Effectsmentioning

confidence: 99%

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Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review

Parrado

Mascaraque

Gilaberte

et al. 2016

IJMS

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“…The VL part of the spectrum has not been thoroughly investigated as compared to UV radiation, regarding both positive and side effects [ 2 ]. VL has been reported to induce both transient [ 3 ] as well as long lasting pigmentation in human skin [ 4 ]. It was shown that VL induced pigmentation may persist up to 8 weeks and the amount of pigment produced is dependent on the total dose of light.…”

Section: Introductionmentioning

confidence: 99%

Visible Light Induces Melanogenesis in Human Skin through a Photoadaptive Response

et al. 2015

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Visible light (400–700 nm) lies outside of the spectral range of what photobiologists define as deleterious radiation and as a result few studies have studied the effects of visible light range of wavelengths on skin. This oversight is important considering that during outdoors activities skin is exposed to the full solar spectrum, including visible light, and to multiple exposures at different times and doses. Although the contribution of the UV component of sunlight to skin damage has been established, few studies have examined the effects of non-UV solar radiation on skin physiology in terms of inflammation, and limited information is available regarding the role of visible light on pigmentation. The purpose of this study was to determine the effect of visible light on the pro-pigmentation pathways and melanin formation in skin. Exposure to visible light in ex-vivo and clinical studies demonstrated an induction of pigmentation in skin by visible light. Results showed that a single exposure to visible light induced very little pigmentation whereas multiple exposures with visible light resulted in darker and sustained pigmentation. These findings have potential implications on the management of photo-aggravated pigmentary disorders, the proper use of sunscreens, and the treatment of depigmented lesions.

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“…It is particularly common in women in their thirties and forties, especially in Asians [ 2 ]. Chronic ultraviolet (UV) exposure, genetic factors, and sex hormones are generally believed to be involved in the occurrence of melasma [ 3 , 4 , 5 , 6 ]. However, the pathogenesis of melasma has not yet been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous Pathology of Melasma and Its Clinical Implications

Kwon

Hwang

Lee

et al. 2016

IJMS

144

138

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Melasma is a commonly acquired hypermelanosis that affects sun-exposed areas of the skin, with frequent facial involvement. Its histologic manifestations are evident in the epidermis, extracellular matrix, and dermis. In addition to epidermal pigmentation, pathologic findings of melasma include extracellular matrix abnormality, especially solar elastosis. The disrupted basement membrane has been described in melasma with variable incidences. In the dermis, an increase in vascularity and an increase in the number of mast cells were observed, indicating that dermal factors have critical roles in the pathogenesis of melasma, despite the fact that melasma is characterized by epidermal hyperpigmentation. This review discusses such histologic characteristics of melasma, with consideration to their implications for melasma treatment.

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Cited by 15 publications

References 8 publications

Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review

Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review

Visible Light Induces Melanogenesis in Human Skin through a Photoadaptive Response

Heterogeneous Pathology of Melasma and Its Clinical Implications

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