Primary Follicular Lymphoma of the Duodenum: A Case Report

Roh, Jin; Huh, Jooryung; Park, Chan-Sik

doi:10.4132/jptm.2016.01.27

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Normal and reactive follicles usually have heterogeneous populations with many tingible body macrophages, good polarization, and negative Bcl-2 expression in the germinal centre [2]. MALT lymphomas rarely form nodules and lymphoepithelial lesions are commonly found [14]. MALT lymphoma usually occurs in the stomach and predominantly consists of small round and monocytoid cells.…”

Section: Discussionmentioning

confidence: 99%

Incidental Findings of Duodenal-Type Follicular Lymphoma by Endoscopic Screening: A Case Report

Saputra,

Sriwidyani,

Paskarani

et al. 2023

Indonesian Journal of Cancer

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Introduction: Follicular Lymphoma (FL) is a B-cell neoplasm arising from the germinal center. Gastrointestinal FL is a rare case, accounting for less than 4% of all primary lymphoma of the gastrointestinal tract. Duodenal-type Follicular Lymphoma (DTFL) was included in an entity of primary intestinal FL. However, in the 2017 World Health Organization (WHO) Classification, this entity was included in a specific variant called DTFL. In this article, we report a case of DTFL in a 56-year-old man which was incidentally found during upper gastrointestinal endoscopy Case Presentation: : We report a case of incidentally found DTFL in a 56-year-old man during an endoscopy. The endoscopic finding showed a small, hypertrophic, or nodular lesion on part two duodenum. Microscopic evaluation of duodenal mucosa consists of proliferative atypical lymphoid cells arranged in follicular architecture. The lesion was confined to the lamina propria. The atypical lymphoid cells were dominated by monotonous centrocyte-like cells, small-sized, with scant cytoplasm, and cleaved nuclei. There were some scattered larger centroblast-like cells with multiple nucleoli. No mantle zone and tingible body macrophage were found. The immunohistochemical evaluation showed positivity for CD 20, CD 10, Bcl-6, and Bcl-2 in the follicular structure. CD 21 was dominantly stained at the periphery of the follicular structure, and Ki-67 was low. Conclusions: According to clinical data, endoscopic findings, and histopathological and immunohistochemical findings, the patient was diagnosed with DTFL.

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Section: Discussionmentioning

confidence: 99%

Incidental Findings of Duodenal-Type Follicular Lymphoma by Endoscopic Screening: A Case Report

Saputra,

Sriwidyani,

Paskarani

et al. 2023

Indonesian Journal of Cancer

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“…Follicular lymphoma is a common type of common type of non-Hodgkin lymphoma and generally has an indolent course and good prognosis [1]. On the other hand, primary GI follicular lymphoma that affects the duodenum is very rare, making up only 1-3% of cases [2], and only a few cases have been reported [3,4].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Primary Duodenal Follicular Lymphoma

Kim

Choi

2022

JDCR

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The role of dual time point PET/CT for distinguishing malignant from benign focal 18F-FDG uptake duodenal lesions

Zhao²,

Dai³

et al. 2018

Medicine

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The aim of this study was to evaluate the diagnostic criteria of dual time point Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in differentiating malignant from benign focal hypermetabolic lesions of duodenum.A total of 50 patients underwent 18F-FDG PET/CT at 2 points: 60 ± 13.7 minutes (early imaging) and 120 ± 26.4 minutes (delayed imaging) after tracer injection. Early maximum standardized uptake value (SUVE), delayed maximum standardized uptake value (SUVD), difference between early and delayed maximum standardized uptake value (D-SUVmax), and retention index (RI) were calculated for each duodenal lesion. Receiver operating characteristic analysis (ROC) was performed to evaluate the discriminating validity of the parameters.There were 32 malignant and 18 benign focal 18F-FDG uptake duodenal lesions. The values of SUVE, SUVD, and D-SUVmax were significantly different between malignant and benign lesions (12.5 ± 6.3 vs 5.8 ± 1.2, 13.5 ± 6.5 vs 5.5 ± 1.1 and 0.3 ± 0.8 vs 1.0 ± 1.0, respectively). The areas under the curves (AUCs) of SUVE, SUVD, D-SUVmax were 0.932, 0.964 and 0.707, respectively. There was no significantly difference between SUVE and SUVD based on AUC. In detecting malignant lesions, SUVE=6.9 yielded a sensitivity of 88.9% and specificity of 84.4%, SUVD=7.2 yielded a sensitivity of 94.6% and specificity of 90.6%, D-SUVmax=0.5 yielded a sensitivity of 72.2% and specificity of 68.8%. SUVD was the best diagnostic indicator, regarding specificity and specificity.SUVE and SUVD had good sensitivity, specificity for differentiating duodenal lesions. But there was no significantly difference between diagnostic value of SUVE and SUVD. 18F-FDG uptake patterns are helpful for differentiating benign and malignant duodenal lesions.

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Primary Follicular Lymphoma of the Duodenum: A Case Report

Cited by 3 publications

References 8 publications

Incidental Findings of Duodenal-Type Follicular Lymphoma by Endoscopic Screening: A Case Report

Incidental Findings of Duodenal-Type Follicular Lymphoma by Endoscopic Screening: A Case Report

A Rare Case of Primary Duodenal Follicular Lymphoma

The role of dual time point PET/CT for distinguishing malignant from benign focal 18F-FDG uptake duodenal lesions

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