Primary Gastric Adenosquamous Carcinoma: A Case Report

Aly, Ragia; Gupta, Sachin; Gupta, Sorab; Nagra, Navroop; Goyal, Abhinav; Singh, Balraj

doi:10.14740/gr1307

Cited by 1 publication

(1 citation statement)

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“…Only one case report presented a GASC case with a CPS of 10, without the loss of expression of DNA mismatch repair proteins. 18 Our study was the first to systemically evaluate CPS, EBER, and dMMR in the GASC population and proposed this phenomenon. Further validation may be required to make a solid conclusion.…”

Section: Discussionmentioning

confidence: 83%

Immunoprofile of adenosquamous carcinoma in gastric cancer

Lai

Teng

et al. 2023

Journal of the Chinese Medical Association

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Background: Gastric adenosquamous carcinoma (GASC) is a rare subtype of gastric cancer. Research on GASC treatment is limited, and its outcome is usually poor. We investigated the clinical features, immunoprofile of GASC, and determined the optimal treatment modality for these patients. Methods: Patients with GASC from Taipei Veterans General Hospital were retrospectively reviewed. Clinical features and treatment outcomes were evaluated. Adequate samples were examined for surrogate biomarkers for immunotherapy by IHC staining. Results: Total 14 (0.35%) GASC patients were found among 4034 gastric cancer patients. The median tumor size was 6.8 cm in 10 patients with stage III GASC, and all these patients underwent radical gastrectomy followed by adjuvant therapy. The median progression-free survival (PFS) and overall survival (OS) were 6.0 and 11.5 months, respectively. Two patients with stage IV GASC received frontline immunotherapy. Their median PFS and OS were 9.0 and 12.5 months. In immunoprofiling, 25.0% (n = 3), 75.0% (n = 9), and 33.3% (n = 4) of the samples had deficient mismatch repair (dMMR) protein, combined positive score (CPS) of ≥1, and CPS of ≥10, respectively. The univariate analysis revealed that programmed death-ligand 1 ≥5% (HR: 0.12; 95% CI: 0.01-0.97; p = 0.047) was significant associated with superior OS. One stage IV patient with CPS ≥10 and dMMR proteins received nivolumab monotherapy as frontline treatment that resulted 14-month PFS. Conclusion: Patients with GASC are more likely to yield positive results for CPS and dMMR. Biomarkers should be examined, and immunotherapy can be considered as frontline systemic treatment.

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Section: Discussionmentioning

confidence: 83%