Primary Gastric Hodgkin's Lymphoma Expressing a B-Cell Profile Including Oct-2 and Bob-1 Proteins

Abstract

Classic Hodgkin's lymphoma (cHL) most often involves lymph nodes, and gastric involvement is rare. Hodgkin's and Reed-Sternberg (H-RS) cells in cHL are known to often lack expression of several B-lineage markers, such as CD20, CD79a, Oct-2, and Bob-1. We present an extremely rare case of mixed-cellularity cHL in the stomach in which expression of these B-cells was detected immunohistochemically. The patient was an 83-year-old Japanese woman who developed a sensation of abdominal fullness and appetite loss. Endoscopic and abdominal computed tomography examinations revealed a gastric ulcer lesion and swelling of para-aortic lymph nodes, respectively. A subtotal gastrectomy was performed, and the histopathologic diagnosis was established as a typical cHL compatible with stomach origin. The patient underwent postoperative chemotherapy of 3 cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and has since been in complete remission. Immunohistochemically, the H-RS cells in the cHL were positive not only for CD30 but also for CD20, CD79a, Oct-2, and Bob-1, whereas they were negative for CD3, CD15, CD45, EMA, and ALK1. Our patient may have had an intermediate cHL disease overlapping that of non-Hodgkin's peripheral B-cell lymphoma, possibly reflecting derivation from germinal-center B-cells.

Primary gastric Hodgkin's lymphoma

“…However, EBV infection was not present in the pathologic portion of the stomach analyzed in our case. Regarding cases of HL located at unusual sites, such as gastric HL, some authors have suggested that the gastric marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type, which is similar to DLBCL, may be a precursor lesion for CHL [9]. The results of tests for H. pylori were positive in our case; however, none of our findings suggested the presence of gastric MALT lymphoma.…”

“…Non-Hodgkin's B-cell lymphomas represent the vast majority of primary gastric lymphomas [1], whereas primary Hodgkin's lymphoma (HL) involving the stomach is exceedingly rare and only a few cases have been reported in the medical literature to date [2-9]. A diagnosis of HL depends primarily on the detection of Reed-Sternberg cells using light microscopy techniques.…”

POU2F2-oriented network promotes human gastric cancer metastasis

“…[2][3][4] Hippo et al 7 discovered a high and specific expression of POU2F2 in metastatic GC tissue, but the molecular mechanisms underlying its effect in GC were far from clear. This study not only reaffirmed the increased expression of POU2F2 in metastatic GC but, more importantly, it also revealed the role of POU2F2 in conferring GC cell metastasis through a direct regulation of ROBO1 and the activation of SLIT2/ROBO1 signalling.…”

“…1 Previous studies have indicated that POU2F2 is normally expressed in B cells and B cell lineage tumour cells [2][3][4] to regulate Ig, B cell proliferation and B cell differentiation genes. 5 Recent studies have identified POU2F2 expression in pancreatic cancer, 6 gastric cancer (GC) 7 and other epithelial tumours.…”

Age-Related Epstein-Barr Virus-Positive Lymphoproliferative Disorders of the Orbit and Maxillary Sinus : A Case Report

“…25,26 Furthermore, Bob-1 and Oct-2, which are thought to be B-lineage markers, were both expressed in the present case. Recent studies have rarely found the expression of Bob-1 in RS cells in cHL, 27 and the absence of functional Oct-2 and/or Bob-1 in RS cells in cHL has also been reported. 28,29 In addition to immunophenotype, the characteristics of the present case, including the site of primary lesions, the absence of other lymph node lesions and the relatively old age, appear to suggest that the present case is aEBVBLPD, rather than cHL.…”